Detailed view for Smp_014170.2

Basic information

TDR Targets ID: 290675
Schistosoma mansoni, serine/threonine protein kinase
Source Database / ID:  GeneDB

pI: 9.362 | Length (AA): 1024 | MW (Da): 111767 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF02149   Kinase associated domain 1

Gene Ontology

Mouse over links to read term descriptions.
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0005524   ATP binding  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 345 3uto (A) 51 417 28.00 0 1 0.591431 0.22
19 340 3i6u (A) 154 487 34.00 0 1 0.645353 -0.03
26 392 5uvc (A) 106 531 25.00 0 1 0.498498 0.14
35 340 4yhj (A) 134 450 26.00 0 1 0.581728 -0.15
37 362 4ejn (A) 63 435 34.00 0 1 0.602259 0.04
83 447 6c9d (A) 56 736 52.00 0 1 1.01085 -0.53
83 397 2r0i (A) 49 361 56.00 0 1 0.848717 -0.43
83 351 3mn3 (A) 51 317 48.00 0 1 0.773595 -0.43
84 512 4rer (A) 15 535 30.00 0 1 0.592045 0.64
87 360 4fgb (A) 20 298 35.00 0 1 0.706478 -0.81
889 1024 3ose (A) 696 795 42.00 0.00000000023 0.98 0.283213 -0.11

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_245942)

Species Accession Gene Product
Echinococcus granulosus EgrG_001156900   serine threonine protein kinase sik
Schistosoma japonicum Sjp_0068350   U6 snRNA-associated Sm-like protein LSm7, putative
Schistosoma japonicum Sjp_0068380   Serine/threonine-protein kinase MARK2, putative
Schistosoma mansoni Smp_014170.2   serine/threonine protein kinase
Schistosoma mansoni Smp_014170.1   serine/threonine protein kinase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 33.5% 170 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 8 411 aa 26.5% 355 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 26.9% 353 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 30.7% 264 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 26.8% 340 aa Compounds References
Sus scrofa Casein kinase I isoform alpha 125 aa 25.0% 128 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.6166 0.3284 0.3281
0.1333 0.3317 0.3317
0.3061 0.2743 0.2743
0.5253 0.333 0.333
0.3429 0.3313 0.3313
0.0264 0.3153 0.3153
0.0636 0.3263 0.3263
0.6745 0.3317 0.3317
0.0181 0.3279 0.3279
0.6255 0.3146 0.3146
0.0081 1 1
0.5793 0.3325 0.3325
0.2053 0.3315 0.3315
0.0987 0.3249 0.3244
0.2088 0.3125 0.3125
0.466 0.3352 0.3351
0.105 0.3304 0.3304
0.2927 0.3318 0.3318
0.3511 0.3329 0.3329
0.3568 0.3317 0.3317
0.0016 0.5 0.5
0.0509 0.3298 0.3296
0.2704 0.3197 0.3197
0.2234 0.3316 0.3316
0.1091 0.3296 0.3296
0.2219 0.3214 0.3214
0.0011 1 1
0.0253 0.3228 0.3191
0.0075 0.2515 0.2515
0.2088 0.3125 0.3125
0.0098 0.3242 0.2614
0.0049 0.2943 0.2943
0.0371 0.329 0.3289
0.466 0.3352 0.3351
0.3326 0.3317 0.3317
0.2399 0.3323 0.3322
0.2219 0.3214 0.3214
0.1877 0.2764 0.2764
0.3326 0.3317 0.3317
0.4153 0.333 0.333
0.0172 0.317 0.317
0.0039 0.9485 1
0.0223 0.3219 0.3127
0.4717 0.2843 0.2507
0.4661 0.3317 0.3317
0.3504 0.3044 0.3044
0.5253 0.333 0.333
0.2399 0.3323 0.3322
0.0178 0.3056 0.3056
0.0456 0.3157 0.3157
0.2347 0.3172 0.3172
0.3527 0.2721 0.2721
0.1509 0.3317 0.3317
0.0232 0.2732 0.3253
0.0745 0.3291 0.3254
0.0446 0.2755 0.2732
0.0448 0.3264 0.3243
0.1058 0.3326 0.3326
0.0506 0.3227 0.3227
0.1999 0.3317 0.3317
0.1117 0.3306 0.3304
0.1331 0.3314 0.3314
0.2233 0.3312 0.3312
0.3477 0.3325 0.3325
0.1891 0.3317 0.3317
0.022 0.3859 0.3859
0.06 0.3273 0.3201
0.5789 0.3317 0.3317
0.4497 0.3318 0.3317
0.0312 0.3189 0.3189
0.2927 0.3318 0.3318
0.0458 0.3269 0.3262
0.2165 0.3231 0.0037
0.1641 0.3315 0.331
0.0091 0.3123 0.3123
0.4661 0.3317 0.3317
0.0347 0.2924 0.2805
0.1281 0.3317 0.3317
0.4146 0.3326 0.3326
0.0383 0.3254 0.3246
0.0312 0.3176 0.3176
0.0049 0.2974 0.2974
0.3504 0.3044 0.3044
0.4356 0.3328 0.3328
0.0092 1 1
0.0049 0.2531 0.1857
0.5793 0.3325 0.3325
0.0012 0.5 0.5
0.2885 0.3317 0.3317
0.3326 0.3317 0.3317
0.105 0.3304 0.3304
0.2053 0.3315 0.3315
0.0678 0.3311 0.3311
0.2831 0.3317 0.3317
0.0039 0.5 0.5
0.099 0.3215 0.3215
0.2763 0.3314 0.3314
0.0049 0.285 0.285
0.005 0.3095 0.3095
0.0016 0.5 0.5
0.2399 0.3323 0.3322
0.2053 0.3315 0.3315
0.3326 0.3317 0.3317
0.4978 0.3316 0.3316
0.0135 0.315 0.315
0.3326 0.3317 0.3317
0.0446 0.3267 0.3195
0.408 0.3204 0.3204
0.0064 0.3377 0.9531
0.0296 0.2927 0.2927
0.168 0.3312 0.3312
0.5793 0.3325 0.3325
0.2428 0.3314 0.3312
0.4885 0.3302 0.3302
0.0026 0.5 0.5
0.2347 0.3172 0.3172
0.0634 0.3276 0.3276
0.0321 0.3099 0.3099
0.0007 0.5 0.5
0.0033 1 1
0.0012 0.5 0.5
0.5138 0.324 0.324
0.0213 0.2916 0.2756
0.1305 0.2812 0.2812
0.2172 0.3024 0.3024
0.0066 0.3101 0.9479
0.1305 0.2812 0.2812
0.0496 0.33 0.33
0.0587 0.3311 0.3311
0.2347 0.3172 0.3172
0.1297 0.3123 0.3123
0.2146 0.3297 0.3293
0.0007 0.5 0.5
0.5116 0.321 0.321
0.0364 0.3051 0.3051
0.1516 0.3317 0.3317
0.0498 0.3315 0.3311
0.261 0.3309 0.3308
0.2399 0.3323 0.3322
0.0545 0.3128 0.303
0.0308 0.3175 0.3175
0.5138 0.324 0.324
0.0049 0.2531 0.1857
0.0267 0.308 0.3267
0.3326 0.3317 0.3317
0.1305 0.2812 0.2812
0.1989 0.3165 0.3165
0.0674 0.3244 0.3195
0.2146 0.3297 0.3293
0.1054 0.3314 0.3314
0.3326 0.3317 0.3317
0.0049 0.2531 0.1857
0.0088 0.3066 0.3066
0.0316 0.3195 0.3161
0.0464 0.3131 0.3131
0.0022 0.5 0.5
0.1366 0.3189 0.3131
0.1615 0.3117 0.2976
0.2401 0.3324 0.3324
0.3975 0.3352 0.3351
0.328 0.3329 0.3329
0.0613 0.3288 0.328
0.2234 0.3316 0.3316
0.0059 1 1
0.0577 0.329 0.329
0.0188 0.2555 0.3253
0.0485 0.41 0.41
0.1309 0.3324 0.3324
0.466 0.3352 0.3351
0.0317 0.2925 0.0037
0.4493 0.3202 0.3113
0.4057 0.3319 0.3319
0.2978 0.3318 0.3318
0.506 0.3209 0.3209
0.4493 0.3202 0.3113
0.0445 0.2699 0.3293
0.5138 0.324 0.324
0.6813 0.3327 0.332
0.4146 0.3326 0.3326
0.0008 0.5 0.5
0.0141 0.2643 0.2643
0.1878 0.3314 0.3314
0.0317 0.2925 0.0037
0.0027 1 1
0.0325 0.3307 0.3307
0.0088 0.4477 0.6337
0.023 0.3144 0.3144
0.3429 0.3313 0.3313
0.5796 0.3328 0.3328
0.3656 0.3324 0.3319
0.169 0.3311 0.3311
0.1292 0.3299 0.3299
0.3326 0.3317 0.3317
0.5895 0.2703 0.2703
0.5793 0.3325 0.3325
0.0063 1 1
0.1297 0.3123 0.3123
0.2136 0.3328 0.3328
0.0303 0.2687 0.3755
0.4146 0.3326 0.3326
0.3879 0.3324 0.3324
0.2242 0.3184 0.3184
0.1045 0.3308 0.3306
0.3061 0.2743 0.2743
0.3326 0.3317 0.3317
0.1277 0.3317 0.3315
0.637 0.3317 0.3317
0.0069 0.3067 0.3067
0.0037 1 0.5
0.1085 0.3297 0.3294
0.0405 0.3287 0.3278
0.466 0.3352 0.3351
0.0042 0.2571 0.1717
0.0245 0.2999 0.2999
0.0371 0.329 0.3289
0.6166 0.3284 0.3281
0.2399 0.3323 0.3322
0.3004 0.3117 0.3073
0.0827 0.3291 0.3282
0.3411 0.3317 0.3317
0.0601 0.2813 0.2813
0.3508 0.3318 0.3317
0.2234 0.3316 0.3316
0.2542 0.3369 0.3368
0.0003 0.5 0.5
0.1736 0.3379 0.3378
0.311 0.3313 0.3313
0.5138 0.324 0.324
0.3061 0.2743 0.2743
0.0042 0.5 0.5
0.0253 0.3158 0.3158
0.0012 0.5 0.5
0.168 0.3312 0.3312
0.0067 0.5 0.5
0.3326 0.3317 0.3317
0.449 0.332 0.3318
0.0091 1 1
0.0368 0.3259 0.3259
0.0098 0.3752 0.3752
0.0268 0.2804 0.3255
0.351 0.3317 0.3317
0.078 0.3091 0.3297
0.0093 0.8828 0
0.1687 0.327 0.327
0.165 0.3251 0.3046
0.0188 0.3082 0.3082
0.2927 0.3318 0.3318
0.3326 0.3317 0.3317
0.0168 0.2549 0.2781
0.0405 0.313 0.3116
0.6241 0.3302 0.329
0.0316 0.3195 0.3161
0.3508 0.3318 0.3317
0.0029 0.5 0.5
0.0059 1 1
0.0415 0.2861 0.2861
0.2155 0.2995 0.0037
0.4893 0.3325 0.3325
0.2004 0.285 0.0038
0.093 0.3248 0.3248
0.4661 0.3317 0.3317
0.0216 0.3264 0.326
0.2399 0.3323 0.3322
0.1587 0.3322 0.3322
0.1859 0.3284 0.3267
0.4146 0.3326 0.3326
0.4356 0.3328 0.3328
0.0517 0.3159 0.3159
0.311 0.3313 0.3313
0.5924 0.2706 0.2706
0.4602 0.3297 0.3297
0.2831 0.3317 0.3317
0.466 0.3352 0.3351
0.0629 0.3319 0.3319
0.0061 0.6883 0.6656
0.0267 0.308 0.3267
0.5253 0.333 0.333
0.2556 0.3313 0.3313
0.2858 0.3315 0.3315
0.3326 0.3317 0.3317
0.3061 0.2743 0.2743
0.2409 0.3242 0.0037
0.0018 0.5 0.5
0.0299 0.3177 0.3194
0.0755 0.3308 0.3308
0.4153 0.333 0.333
0.3617 0.3317 0.3317
0.3359 0.3322 0.3322
0.3061 0.2743 0.2743
0.0855 0.3307 0.3307
0.466 0.3352 0.3351
0.0279 0.325 0.3277
0.0671 0.2571 0.2571
0.0321 0.3099 0.3099
0.0133 0.2566 0.2566
0.3543 0.3317 0.3317
0.0088 0.3066 0.3066
0.3004 0.3117 0.3073
0.1717 0.3321 0.3321
0.0253 0.3228 0.3191
0.1509 0.3317 0.3317
0.3894 0.3325 0.3325
0.0196 0.3166 0.3166
0.0032 0.5 0.5
0.0049 0.2531 0.1857
0.5793 0.3325 0.3325
0.0566 0.2609 0.0037
0.227 0.3325 0.3325
0.3527 0.2721 0.2721
0.5796 0.3328 0.3328
0.14 0.332 0.332
0.1054 0.3314 0.3314
0.4083 0.3317 0.3317
0.2831 0.3317 0.3317
0.0059 1 1
0.2831 0.3317 0.3317
0.2615 0.3302 0.3302
0.4037 0.2821 0.0037
0.0091 0.295 0.2579
0.5793 0.3325 0.3325
0.0023 0.5 0.5
0.5965 0.3316 0.3316
0.1615 0.3117 0.2976
0.0231 0.2698 0.0037
0.5163 0.3261 0.3261
0.0498 0.3315 0.3311
0.0259 0.311 0.3248
0.0434 0.3141 0.3141
0.0062 0.6935 0.7231
0.4153 0.333 0.333
0.0467 0.3286 0.3286
0.3562 0.3325 0.3323
0.1891 0.3317 0.3317
0.0339 0.3061 0.2882
0.4316 0.3344 0.3344
0.3894 0.3325 0.3325
0.0032 0.5 0.5
0.0674 0.3245 0.3245
0.0383 0.3213 0.3211
0.165 0.3251 0.3046
0.2637 0.2785 0.0037
0.5793 0.3325 0.3325
0.4717 0.2843 0.2507
0.1482 0.2829 0.0037
0.4986 0.3311 0.3122
0.3326 0.3317 0.3317
0.466 0.3352 0.3351
0.0189 0.3137 0.3137
0.036 0.3214 0.3214
0.0307 0.3242 0.318
0.0253 0.3228 0.3191
0.013 0.3239 0.3161
0.2713 0.33 0.3298
0.3682 0.328 0.326
0.4037 0.2821 0.0037
0.0328 0.3207 0.2967
0.466 0.3352 0.3351
0.2592 0.3296 0.3296
0.2704 0.3197 0.3197
0.506 0.3209 0.3209
0.169 0.3311 0.3311
0.0674 0.3244 0.3195
0.0039 0.5 0.5
0.0385 0.2704 0.2704
0.2399 0.3323 0.3322
0.4776 0.333 0.333
0.2088 0.3125 0.3125
0.4993 0.3305 0.3305
0.0498 0.3095 0.3095
0.0514 0.327 0.327
0.0395 0.3007 0.3007
0.0735 0.3298 0.3298
0.0303 0.2687 0.3755
0.0036 0.5 0.5
0.3617 0.3317 0.3317
0.0566 0.2609 0.0037
0.4146 0.3326 0.3326
0.146 0.3305 0.3269
0.0859 0.322 0.322
0.3527 0.2721 0.2721
0.2996 0.3288 0.0037
0.0698 0.329 0.3273
0.2527 0.3313 0.3313
0.5138 0.324 0.324
0.509 0.3215 0.3215
0.2763 0.3314 0.3314
0.4986 0.3311 0.3122
0.3326 0.3317 0.3317
0.2615 0.3302 0.3302
0.1987 0.3021 0.3021
0.6166 0.3284 0.3281
0.0245 0.2999 0.2999
0.039 0.3245 0.3245
0.0164 0.414 0.414
0.0049 0.2531 0.1857
0.3894 0.3325 0.3325
0.078 0.3091 0.3297
0.2399 0.3323 0.3322
0.0224 0.2737 0.3263
0.2257 0.3314 0.3314
0.2234 0.3316 0.3316
0.1177 0.2638 0.0037
0.0056 1 1
0.0422 0.3268 0.3268
0.0033 0.5 0.5
0.1687 0.327 0.327
0.2399 0.3323 0.3322
0.0303 0.2687 0.3755
0.0557 0.3028 0.2682
0.1641 0.3315 0.331
0.2257 0.3314 0.3314
0.0196 0.3166 0.3166
0.2053 0.3315 0.3315
0.0514 0.3314 0.3314
0.3894 0.3325 0.3325
0.454 0.299 0.0037
0.0081 0.5 0.5
0.2164 0.2732 0.267
0.1718 0.3312 0.3303
0.3511 0.3329 0.3329
0.2349 0.3294 0.3294
0.0063 0.7244 0
0.2576 0.3204 0.3204
0.0517 0.3288 0.0037
0.0004 0.5 0.5
0.0561 0.3296 0.3296
0.3919 0.3317 0.3317
0.2347 0.3172 0.3172
0.3411 0.3317 0.3317
0.3326 0.3317 0.3317
0.3326 0.3317 0.3317
0.1453 0.3308 0.3308
0.5261 0.3189 0.0037
0.1717 0.3321 0.3321
0.2146 0.3297 0.3293
0.0187 0.3245 0.3236
0.6373 0.3015 0.0037
0.0308 0.3175 0.3175
0.0007 0.5 0.5
0.2556 0.3313 0.3313
0.5793 0.3325 0.3325
0.1545 0.3312 0.3312
0.2117 0.3322 0.3322
0.2987 0.3321 0.3317
0.2221 0.3322 0.3322
0.3326 0.3317 0.3317
0.2172 0.3024 0.3024
0.1893 0.3317 0.3317
0.4885 0.3302 0.3302
0.06 0.3273 0.3201
0.637 0.3317 0.3317

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_014170.2 (Schistosoma mansoni), serine/threonine protein kinase
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