pI: 6.3918 |
Length (AA): 1729 |
MW (Da): 192512 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 10 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 447 | 5ncl (A) | 287 | 754 | 38.00 | 0 | 1 | 0.300717 | 0.81 |
16 | 436 | 5wnf (C) | 4 | 402 | 45.00 | 0 | 1 | 0.616993 | -0.08 |
26 | 426 | 2f2u (A) | 30 | 409 | 45.00 | 0 | 1 | 0.541026 | -0.09 |
37 | 407 | 4aw2 (A) | 26 | 393 | 43.00 | 0 | 1 | 0.660775 | -0.26 |
80 | 368 | 5lvo (A) | 73 | 358 | 36.00 | 0 | 1 | 0.551649 | -0.59 |
87 | 429 | 5vhb (A) | 42 | 351 | 39.00 | 0 | 1 | 0.354481 | 0.04 |
88 | 403 | 1mrv (A) | 151 | 439 | 43.00 | 0 | 1 | 0.373965 | 0.49 |
89 | 637 | 4kik (B) | 15 | 576 | 22.00 | 0 | 1 | 0.269025 | 0.94 |
1430 | 1500 | 2row (A) | 14 | 84 | 27.00 | 0 | 0.3 | 0.242564 | 0.14 |
1441 | 1497 | 4l9m (A) | 542 | 593 | 29.00 | 0.28 | 0.11 | 0.126467 | 0.33 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_246280)
Species | Accession | Gene Product |
---|---|---|
Echinococcus granulosus | EgrG_000067600 | rho-associated protein kinase |
Echinococcus multilocularis | EmuJ_000067600 | rho associated protein kinase 1 |
Schistosoma japonicum | Sjp_0061060 | expressed protein |
Schistosoma japonicum | Sjp_0061070 | Rho-associated protein kinase 2, putative |
Schistosoma mansoni | Smp_151140 | serine/threonine protein kinase |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 37.7% | 334 aa | Compounds | References |
Oryctolagus cuniculus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 35.7% | 347 aa | Compounds | References |
Bos taurus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 37.2% | 347 aa | Compounds | References |
Schizosaccharomyces pombe 972h- | Casein kinase II subunit alpha | 332 aa | 21.9% | 315 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 27.6% | 304 aa | Compounds | References |
Rattus norvegicus | Serine/threonine-protein kinase pim-3 | 326 aa | 25.6% | 289 aa | Compounds | References |