Detailed view for Smp_159730.1

Basic information

TDR Targets ID: 291681
Schistosoma mansoni, protein kinase
Source Database / ID:  GeneDB

pI: 7.8307 | Length (AA): 968 | MW (Da): 103422 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF00786   P21-Rho-binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
111 155 1ees (B) 2 46 44.00 0 0.19 0.297688 1.77
119 188 1ytc (A) 24 102 34.00 0.41 0.69 0.265314 0.3
120 188 1f3m (A) 78 147 41.00 0 0.85 0.618481 -0.93
600 953 4g3c (B) 346 674 27.00 0 1 0.374902 0.7
629 966 6fd3 (A) 260 552 74.00 0 1 1.08537 -0.77
666 960 2x7f (D) 39 302 45.00 0 1 0.483952 0
767 968 4lg4 (D) 96 298 49.00 0 1 0.760678 -0.98
768 947 2a2a (A) 91 275 30.00 0 1 0.61395 -1.04
798 902 3e3p (A) 132 239 37.00 0.000000046 0.88 0.548471 -0.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_179020)

Species Accession Gene Product
Echinococcus granulosus EgrG_002003200   serine:threonine protein kinase PAK 1
Echinococcus granulosus EgrG_000558800   3'partial|serine:threonine protein kinase PAK 2
Echinococcus multilocularis EmuJ_000558800   PAK box P21 Rho binding
Schistosoma japonicum Sjp_0002150   Serine/threonine-protein kinase PAK 3, putative
Schistosoma mansoni Smp_159730.2   hypothetical protein
Schistosoma mansoni Smp_159730.1   protein kinase
Schmidtea mediterranea mk4.012862.00   Serine/threonine kinase
Schmidtea mediterranea mk4.009410.06   Serine/threonine kinase
Schmidtea mediterranea mk4.001559.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus MAP kinase p38 alpha 360 aa 21.6% 338 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 25.9% 328 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 8 411 aa 24.9% 341 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 23.6% 339 aa Compounds References
Patiria pectinifera Cdc2 300 aa 27.0% 318 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 24.8% 326 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 23.5% 336 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0032 0.5 0.5
0.005 0.2719 0.2719
0.0419 0.4139 0.4139
0.0036 0.5 0.5
0.0435 0.3908 0.3908
0.0421 0.2844 0.2844
0.0016 0.5 0.5
0.0022 0.5 0.5
0.0042 0.5 0.5
0.0046 0.3971 0.3971
0.0029 0.5 0.5
0.0138 0.3835 0.3785
0.0007 0.5 0.5
0.0123 0.3776 0.3776
0.0493 0.2741 0.2849
0.0098 0.3242 0.2614
0.0092 1 1
0.0016 0.5 0.5
0.0123 0.375 0.4406
0.022 0.3661 0.3661
0.0212 0.4161 0.4161
0.0161 0.3053 0.3053
0.0026 0.5 0.5
0.0387 0.4156 0.4103
0.0421 0.4115 0.4115
0.0062 0.6935 0.7231
0.0118 0.3737 0.3659
0.0091 1 1
0.0493 0.2741 0.2849
0.0493 0.2741 0.2849
0.0124 0.4038 0.3661
0.0039 0.5 0.5
0.0421 0.2844 0.2844
0.0018 0.5 0.5
0.0125 0.3651 0.3651
0.0033 0.5 0.5
0.0115 0.396 0.396
0.0119 0.3913 0.3871
0.0313 0.4135 0.4069
0.0067 0.5 0.5
0.0421 0.2844 0.2844
0.0056 1 1
0.0007 0.5 0.5
0.0101 0.2509 0.2509
0.0012 0.5 0.5
0.0023 0.5 0.5
0.017 0.2959 0.2959
0.0033 1 1
0.0118 0.3737 0.3659
0.0421 0.2844 0.2844
0.0064 0.3377 0.9531
0.0103 0.3605 0.3605
0.0493 0.2741 0.2849
0.0419 0.4139 0.4139
0.0151 0.3689 0.3689
0.0032 0.5 0.5
0.0123 0.3776 0.3776
0.0118 0.3737 0.3659
0.0405 0.3077 0.0153
0.0388 0.3624 0.3624
0.0421 0.2844 0.2844
0.0037 1 0.5
0.0476 0.403 0.403
0.0421 0.2844 0.2844
0.0506 0.3268 0.3268
0.0039 0.5 0.5
0.0039 0.9485 1
0.0125 0.3641 0.3641
0.0011 1 1
0.0421 0.347 0.2373
0.0008 0.5 0.5
0.0063 1 1
0.0081 0.5 0.5
0.0027 1 1
0.0003 0.5 0.5
0.0093 0.8828 0
0.0069 0.3067 0.3067
0.0012 0.5 0.5
0.0167 0.3736 0.3736
0.0081 1 1
0.0059 1 1
0.0139 0.3821 0.3768
0.0138 0.379 0.3727
0.0059 1 1
0.0506 0.3268 0.3268
0.0418 0.4386 0.4386
0.0506 0.3268 0.3268
0.0007 0.5 0.5
0.0059 1 1
0.0063 0.7244 0
0.0064 0.2501 0.2501
0.0088 0.4477 0.6337
0.0506 0.3268 0.3268
0.0004 0.5 0.5
0.0418 0.4386 0.4386
0.0096 0.2561 0.2561
0.0012 0.5 0.5
0.0066 0.3101 0.9479
0.0215 0.4041 0.4006
0.0061 0.6883 0.6656

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_159730.1 (Schistosoma mansoni), protein kinase
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