pI: 6.6044 |
Length (AA): 493 |
MW (Da): 55092 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
24 | 470 | 3cb2 (A) | 2 | 446 | 80.00 | 0 | 1 | 1.92869 | -1.6 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127652)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G05620 | tubulin gamma-2 chain |
Arabidopsis thaliana | AT3G61650 | tubulin gamma-1 chain |
Babesia bovis | BBOV_IV007250 | tubulin gamma chain |
Brugia malayi | Bm1_55245 | Tubulin gamma chain |
Candida albicans | CaO19.8823 | gamma tubulin-like protein |
Candida albicans | CaO19.1238 | gamma tubulin-like protein |
Caenorhabditis elegans | CELE_F58A4.8 | Protein TBG-1 |
Cryptosporidium hominis | Chro.70228 | gamma-tubulin |
Cryptosporidium parvum | cgd7_1980 | gamma tubulin |
Dictyostelium discoideum | DDB_G0271738 | gamma tubulin |
Drosophila melanogaster | Dmel_CG17566 | gamma-Tubulin at 37C |
Drosophila melanogaster | Dmel_CG3157 | gamma-Tubulin at 23C |
Echinococcus granulosus | EgrG_001099700 | tubulin gamma 1 chain |
Entamoeba histolytica | EHI_008240 | tubulin gamma chain |
Echinococcus multilocularis | EmuJ_001099700 | tubulin gamma 1 chain |
Giardia lamblia | GL50803_114218 | Gamma tubulin |
Homo sapiens | ENSG00000131462 | tubulin, gamma 1 |
Homo sapiens | ENSG00000037042 | tubulin, gamma 2 |
Leishmania braziliensis | LbrM.25.0840 | gamma-tubulin |
Leishmania donovani | LdBPK_250990.1 | tubulin gamma chain |
Leishmania infantum | LinJ.25.0990 | gamma-tubulin |
Leishmania major | LmjF.25.0960 | gamma-tubulin |
Leishmania mexicana | LmxM.25.0960 | gamma-tubulin |
Loa Loa (eye worm) | LOAG_02400 | tubulin gamma chain |
Mus musculus | ENSMUSG00000045007 | tubulin, gamma 2 |
Mus musculus | ENSMUSG00000035198 | tubulin, gamma 1 |
Neospora caninum | NCLIV_046130 | Beta-tubulin, related |
Oryza sativa | 4337861 | Os05g0156600 |
Plasmodium berghei | PBANKA_1226600 | tubulin gamma chain, putative |
Plasmodium falciparum | PF3D7_0803700 | tubulin gamma chain |
Plasmodium knowlesi | PKNH_0115200 | tubulin gamma chain, putative |
Plasmodium vivax | PVX_093560 | tubulin gamma chain, putative |
Plasmodium yoelii | PY00808 | tubulin gamma chain |
Saccharomyces cerevisiae | YLR212C | Tub4p |
Schistosoma japonicum | Sjp_0036720 | ko:K10389 tubulin gamma, putative |
Schistosoma mansoni | Smp_034670 | tubulin subunit gamma |
Schmidtea mediterranea | mk4.005127.01 | Tubulin gamma chain |
Schmidtea mediterranea | mk4.005127.02 | Tubulin gamma chain |
Schmidtea mediterranea | mk4.005127.00 | Tubulin gamma chain |
Schmidtea mediterranea | mk4.006572.00 | Tubulin gamma chain |
Trypanosoma brucei gambiense | Tbg972.3.550 | gamma tubulin |
Trypanosoma brucei | Tb927.3.910 | tubulin gamma chain |
Trypanosoma congolense | TcIL3000_0_03350 | tubulin gamma chain |
Trypanosoma cruzi | TcCLB.511867.190 | tubulin gamma chain |
Theileria parva | TP03_0233 | tubulin gamma chain, putative |
Trichomonas vaginalis | TVAG_109820 | tubulin gamma chain, putative |
Trichomonas vaginalis | TVAG_369500 | tubulin, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.3.910 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.910 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.910 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.3.910 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F58A4.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F58A4.8 | Caenorhabditis elegans | sterile | wormbase |
YLR212C | Saccharomyces cerevisiae | inviable | yeastgenome |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Leishmania major | gamma-tubulin | Compounds | References |
Trypanosoma brucei | tubulin gamma chain | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Bos taurus | Tubulin | 85 aa | 40.3% | 77 aa | Compounds | References |
Sus scrofa | Tubulin | 445 aa | 33.5% | 436 aa | Compounds | References |
Sus scrofa | Tubulin alpha chain | 451 aa | 31.5% | 451 aa | Compounds | References |
Leishmania donovani | Beta tubulin | 43 aa | 50.0% | 36 aa | Compounds | References |
Bos taurus | Tubulin | 445 aa | 33.7% | 436 aa | Compounds | References |
Ovis aries | Tubulin alpha 4a | 448 aa | 31.6% | 455 aa | Compounds | References |
Rattus norvegicus | Tubulin alpha-1 chain | 451 aa | 31.5% | 451 aa | Compounds | References |
Bos taurus | Tubulin beta chain | 445 aa | 33.7% | 436 aa | Compounds | References |