Detailed view for Smp_064830

Basic information

TDR Targets ID: 291959
Schistosoma mansoni, survival motor neuron protein

Source Database / ID:  GeneDB

pI: 8.5862 | Length (AA): 212 | MW (Da): 24251 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06003   Survival motor neuron protein (SMN)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005737   cytoplasm  
GO:0005634   nucleus  
GO:0003723   RNA binding  
GO:0003676   nucleic acid binding  
GO:0006397   mRNA processing  

Metabolic Pathways

Spliceosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
53 113 4a4f (A) 65 126 39.00 0 0.99 0.806136 -0.64
60 112 4qq6 (A) 91 144 34.00 0 0.88 0.6584 -0.18

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein


No expression data available for this gene


Ortholog group members (OG5_130055)

Species Accession Gene Product
Arabidopsis thaliana AT2G02570   nucleic acid binding/RNA binding protein
Brugia malayi Bm1_56295   survival motor neuron domain containing protein, putative
Caenorhabditis elegans CELE_Y71D11A.2   Protein SMR-1, isoform B
Dictyostelium discoideum DDB_G0293636   hypothetical protein
Drosophila melanogaster Dmel_CG17454   CG17454 gene product from transcript CG17454-RA
Echinococcus granulosus EgrG_000478900   Survival of motor neuron splicing factor
Echinococcus multilocularis EmuJ_000478900   Survival of motor neuron splicing factor
Homo sapiens 10285   survival motor neuron domain containing 1
Loa Loa (eye worm) LOAG_00331   hypothetical protein
Mus musculus ENSMUSG00000025024   survival motor neuron domain containing 1
Oryza sativa 4344474   Os08g0109900
Schistosoma japonicum Sjp_0115250   Survival of motor neuron-related-splicing factor 30, putative
Schistosoma japonicum Sjp_0058940   Survival of motor neuron-related-splicing factor 30, putative
Schistosoma mansoni Smp_064830   survival motor neuron protein
Schmidtea mediterranea mk4.001427.00  


Smp_064830 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y71D11A.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y71D11A.2 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site,, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model


Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Smp_064830 (Schistosoma mansoni), survival motor neuron protein
Title for this comment