Detailed view for Smp_142500

Basic information

TDR Targets ID: 292653
Schistosoma mansoni, hypothetical protein

Source Database / ID:  GeneDB

pI: 7.7179 | Length (AA): 674 | MW (Da): 76766 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00041   Fibronectin type III domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
275 389 4u3h (A) 14 100 37.00 0.043 0.88 0.292623 0.03
275 370 1wfn (A) 15 95 25.00 0 0.73 0.259433 -0.1
276 391 2ekj (A) 6 98 25.00 0 0.98 0.280107 -0.36
277 389 4ov6 (F) 1 94 24.00 0 0.46 0.289656 -0.52

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132814)

Species Accession Gene Product
Brugia malayi Bm1_14185   Fibronectin type III domain containing protein
Caenorhabditis elegans CELE_K03D10.1   Protein KAL-1
Drosophila melanogaster Dmel_CG6173   Kallmann syndrome 1 ortholog
Echinococcus granulosus EgrG_000888900   anosmin 1
Echinococcus multilocularis EmuJ_000888900   anosmin 1
Homo sapiens ENSG00000011201   Kallmann syndrome 1 sequence
Loa Loa (eye worm) LOAG_07735   fibronectin type III domain-containing protein
Mus musculus 102642186   WAP four-disulfide core domain protein 18-like
Mus musculus ENSMUSG00000069792   WAP four-disulfide core domain 17
Mus musculus 102635563   predicted gene 11433
Mus musculus ENSMUSG00000000983   WAP four-disulfide core domain 18
Schistosoma japonicum Sjp_0058070   Anosmin-1 precursor, putative
Schistosoma japonicum Sjp_0096140   Anosmin-1 precursor, putative
Schistosoma japonicum Sjp_0315280   expressed protein
Schistosoma mansoni Smp_142500   hypothetical protein
Schmidtea mediterranea mk4.055418.00  
Schmidtea mediterranea mk4.000286.03  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0089 0.4623 0.4623
0.0275 0.301 0.301
0.0165 0.3513 0.4019
0.0471 0.341 0.3405
0.0313 0.5953 0.7027
0.037 0.706 0.706
0.0343 0.706 0.706
0.0104 0.8804 1
0.0085 0.3268 0.3432
0.0084 0.6788 1
0.017 0.2614 0.6652
0.0414 0.6115 0.6115
0.0461 0.2819 0.2813
0.0111 0.334 1
0.022 0.257 0.6919
0.0115 0.2557 0.2988
0.0129 0.3276 0.3276
0.0178 0.5983 0.5983
0.0446 0.3014 0.4674
0.0251 0.7407 0.7375
0.0446 0.3014 0.4674
0.0271 0.3613 0.7611
0.0338 0.7566 0.752
0.0155 0.3568 0.706
0.0039 0.3299 0.3527
0.0116 0.6967 0.6967
0.0461 0.2819 0.2813
0.0448 0.7636 0.7636
0.0334 0.4633 0.4633
0.0142 0.2992 0.3276
0.0475 0.706 0.706
0.0016 1 0.5
0.0009 0.5 0.5
0.0167 0.3197 0.351
0.0251 0.7407 0.7375
0.02 0.7068 0.706
0.0132 0.2972 0.7394
0.0446 0.3014 0.4674
0.0336 0.3462 0.4786
0.0216 0.706 0.706
0.0167 0.3197 0.351
0.0153 0.3082 0.3318
0.0275 0.301 0.301
0.0178 0.5983 0.5983
0.0084 0.6788 1
0.0241 0.3619 0.413
0.0089 0.442 0.6887
0.0351 0.6072 0
0.0165 0.3513 0.4019
0.0374 0.7576 0.7576
0.0446 0.3014 0.4674
0.0266 0.2855 0.5677
0.0488 0.3798 0.3794
0.0344 0.6972 0.6972
0.043 0.5151 0.5151
0.0275 0.301 0.301
0.0089 0.442 0.6887
0.0374 0.7576 0.7576
0.0216 0.3372 0.387
0.0258 0.3891 0.4414
0.0048 0.432 0.432
0.012 0.7362 0.7362
0.0446 0.3014 0.4674
0.0272 0.706 0.706
0.0312 0.5397 0
0.0083 1 0.5
0.0034 0.2581 0.2581
0.0461 0.2819 0.2813
0.0446 0.3014 0.4674
0.0223 0.4639 0.4639
0.0446 0.3014 0.4674
0.0075 0.4317 0.4447
0.0255 0.706 0.706
0.0255 0.2557 0.2988
0.008 0.4641 0
0.0275 0.301 0.301
0.0223 0.4639 0.4639
0.0378 0.586 0.586
0.0261 0.3873 0.4396
0.022 0.257 0.6919
0.0334 0.4633 0.4633
0.0048 0.4176 0.4176
0.0255 0.706 0.706
0.0461 0.2819 0.2813
0.0446 0.3014 0.4674
0.0378 0.586 0.586
0.012 0.7362 0.7362
0.0156 0.6042 0.6042
0.0414 0.6115 0.6115
0.0184 0.706 0.706
0.0403 0.706 0.706
0.0114 0.6153 0.3459
0.0164 0.7647 0.7647
0.0471 0.341 0.3405
0.0261 0.2557 0.2988
0.0241 0.3986 0.4512
0.0343 0.706 0.706
0.0275 0.301 0.301
0.0156 0.6042 0.6042

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_142500 (Schistosoma mansoni), hypothetical protein
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