Detailed view for LmjF.16.1015

Basic information

TDR Targets ID: 29277
Leishmania major, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.4791 | Length (AA): 858 | MW (Da): 93791 | Paralog Number: 8

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF11380   Stealth protein CR2, conserved region 2
PF17102   Stealth protein CR3, conserved region 3

Gene Ontology

Mouse over links to read term descriptions.
GO:0016772   transferase activity, transferring phosphorus-containing groups  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
354 436 3gn3 (A) 59 137 30.00 0.87 0.65 0.409937 -0.07
633 740 2a4k (A) 122 218 35.00 0.98 0.15 0.127074 1.75

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_132978)

Species Accession Gene Product
Leishmania braziliensis LbrM.16.1050   hypothetical protein, conserved
Leishmania braziliensis LbrM.16.1020   hypothetical protein, conserved
Leishmania braziliensis LbrM.16.1030   hypothetical protein, conserved
Leishmania braziliensis LbrM.16.1040   hypothetical protein, conserved
Leishmania braziliensis LbrM.16.1010   hypothetical protein, conserved
Leishmania braziliensis LbrM.16.1080   hypothetical protein, unknown function
Leishmania braziliensis LbrM.16.1070   hypothetical protein, conserved
Leishmania donovani LdBPK_161090.1   Protein of unknown function (DUF3184), putative
Leishmania donovani LdBPK_161040.1   Protein of unknown function (DUF3184), putative
Leishmania donovani LdBPK_161060.1   Protein of unknown function (DUF3184), putative
Leishmania donovani LdBPK_161080.1   Protein of unknown function (DUF3184), putative
Leishmania donovani LdBPK_161050.1   Protein of unknown function (DUF3184), putative
Leishmania donovani LdBPK_161030.1   Protein of unknown function (DUF3184), putative
Leishmania infantum LinJ.16.1030   hypothetical protein, unknown function
Leishmania infantum LinJ.16.1070   hypothetical protein, unknown function
Leishmania infantum LinJ.16.1080   hypothetical protein, conserved
Leishmania infantum LinJ.16.1050   hypothetical protein, conserved
Leishmania infantum LinJ.16.1020   hypothetical protein, conserved
Leishmania infantum LinJ.16.1040   hypothetical protein, conserved
Leishmania infantum LinJ.16.1060   hypothetical protein, conserved
Leishmania infantum LinJ.16.1090   hypothetical protein, unknown function
Leishmania major LmjF.16.1060   hypothetical protein, unknown function
Leishmania major LmjF.16.1015   hypothetical protein, conserved
Leishmania major LmjF.16.1010   hypothetical protein, conserved
Leishmania major LmjF.16.1000   hypothetical protein, conserved
Leishmania major LmjF.16.1040   hypothetical protein, unknown function
Leishmania major LmjF.16.1030   hypothetical protein, conserved
Leishmania major LmjF.16.1020   hypothetical protein, conserved
Leishmania major LmjF.16.1050   hypothetical protein, conserved
Leishmania major LmjF.16.1005   hypothetical protein, unknown function
Leishmania mexicana LmxM.16.1015   hypothetical protein, conserved
Leishmania mexicana LmxM.16.1050   hypothetical protein, conserved
Leishmania mexicana LmxM.16.1010partial  
Leishmania mexicana LmxM.16.1005   hypothetical protein, unknown function
Leishmania mexicana LmxM.16.1000   hypothetical protein, conserved
Leishmania mexicana LmxM.16.1060   hypothetical protein, unknown function
Trypanosoma cruzi TcCLB.507275.20   hypothetical protein, conserved

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LmjF.16.1015 (Leishmania major), hypothetical protein, conserved
Title for this comment
Comment