Detailed view for PF3D7_1462800

Basic information

TDR Targets ID: 2928
Plasmodium falciparum, glyceraldehyde-3-phosphate dehydrogenase

Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 7.645 | Length (AA): 337 | MW (Da): 36635 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00044   Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
PF02800   Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016620   oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor  
GO:0051287   NAD binding  
GO:0050661   NADP binding  
GO:0008943   glyceraldehyde-3-phosphate dehydrogenase activity  
GO:0005488   binding  
GO:0003824   catalytic activity  
GO:0055114   oxidation reduction  
GO:0008152   metabolic process  
GO:0006094   gluconeogenesis  
GO:0006006   glucose metabolic process  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 337 2d2i (A) 1 336 45.00 0 1 1.58 -1.25
4 335 2b4r (O) 4 335 99.99 0 1 2.25 -1.78
4 336 2b4r (O) 4 336 99.99 0.000000011 1 2.15813 -1.34

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

  • 1YWG:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 2B4R:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 2B4T:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring, Sporozoite, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Female Gametocyte. Lasonder E
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_126628)

Species Accession Gene Product
Arabidopsis thaliana AT1G42970   glyceraldehyde-3-phosphate dehydrogenase B
Arabidopsis thaliana AT3G04120   glyceraldehyde-3-phosphate dehydrogenase C subunit 1
Arabidopsis thaliana AT1G79530   glyceraldehyde-3-phosphate dehydrogenase GAPCP1
Arabidopsis thaliana AT3G26650   glyceraldehyde-3-phosphate dehydrogenase A subunit
Arabidopsis thaliana AT1G16300   glyceraldehyde 3-phosphate dehydrogenase
Babesia bovis BBOV_II002540   glyceraldehyde-3-phosphate dehydrogenase protein
Brugia malayi Bm1_41940   Glyceraldehyde 3-phosphate dehydrogenase
Candida albicans CaO19.6814   glyceraldehyde-3-phosphate dehydrogenase (GAPDH), C. albicans cell surface antigen
Candida albicans CaO19.14106   glyceraldehyde-3-phosphate dehydrogenase (GAPDH), C. albicans cell surface antigen
Caenorhabditis elegans CELE_K10B3.8   Protein GPD-2
Caenorhabditis elegans CELE_T09F3.3   Protein GPD-1
Caenorhabditis elegans CELE_K10B3.7   Protein GPD-3
Caenorhabditis elegans CELE_F33H1.2   Protein GPD-4
Cryptosporidium hominis Chro.60434   glyceraldehyde-3-phosphate dehydrogenase
Cryptosporidium parvum cgd6_3790   glyceraldehyde 3-phosphate dehydrogenase
Chlamydia trachomatis CT_505   glyceraldehyde-3-phosphate dehydrogenase
Dictyostelium discoideum DDB_G0275153   NAD+-dependent glyceraldehyde phosphate dehydrogenase
Drosophila melanogaster Dmel_CG8893   Glyceraldehyde 3 phosphate dehydrogenase 2
Drosophila melanogaster Dmel_CG9010   CG9010 gene product from transcript CG9010-RA
Drosophila melanogaster Dmel_CG12055   Glyceraldehyde 3 phosphate dehydrogenase 1
Escherichia coli b2927   D-erythrose 4-phosphate dehydrogenase
Escherichia coli b1779   glyceraldehyde-3-phosphate dehydrogenase A
Echinococcus granulosus EgrG_000254600   glyceraldehyde 3 phosphate dehydrogenase
Echinococcus granulosus EgrG_001101100   glyceraldehyde 3 phosphate dehydrogenase
Echinococcus granulosus EgrG_000429600   glyceraldehyde 3 phosphate dehydrogenase
Entamoeba histolytica EHI_008200   glyceraldehyde-3-phosphate dehydrogenase, putative
Entamoeba histolytica EHI_187020   glyceraldehyde-3-phosphate dehydrogenase, putative
Entamoeba histolytica EHI_167320   glyceraldehyde-3-phosphate dehydrogenase, putative
Echinococcus multilocularis EmuJ_001101100   glyceraldehyde 3 phosphate dehydrogenase
Echinococcus multilocularis EmuJ_000254600   glyceraldehyde 3 phosphate dehydrogenase
Echinococcus multilocularis EmuJ_000429600   glyceraldehyde 3 phosphate dehydrogenase
Giardia lamblia GL50803_6687   Glyceraldehyde 3-phosphate dehydrogenase
Homo sapiens ENSG00000105679   glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
Homo sapiens ENSG00000111640   glyceraldehyde-3-phosphate dehydrogenase
Leishmania braziliensis LbrM.30.2950   glyceraldehyde 3-phosphate dehydrogenase, glycosomal
Leishmania donovani LdBPK_362480.1   glyceraldehyde 3-phosphate dehydrogenase, cytosolic
Leishmania donovani LdBPK_303000.1   glyceraldehyde 3-phosphate dehydrogenase, glycosomal
Leishmania infantum LinJ.30.3000   glyceraldehyde 3-phosphate dehydrogenase, glycosomal
Leishmania infantum LinJ.30.2990   glyceraldehyde 3-phosphate dehydrogenase, glycosomal
Leishmania infantum LinJ.36.2480   glyceraldehyde 3-phosphate dehydrogenase, cytosolic
Leishmania major LmjF.30.2980   glyceraldehyde 3-phosphate dehydrogenase, glycosomal
Leishmania major LmjF.30.2970   glyceraldehyde 3-phosphate dehydrogenase, glycosomal
Leishmania mexicana LmxM.29.2980   glyceraldehyde 3-phosphate dehydrogenase, glycosomal
Leishmania mexicana LmxM.36.2350   glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative
Loa Loa (eye worm) LOAG_12990   hypothetical protein
Loa Loa (eye worm) LOAG_12084   glyceraldehyde 3-phosphate dehydrogenase
Loa Loa (eye worm) LOAG_06426   glyceraldehyde-3-phosphate dehydrogenase
Loa Loa (eye worm) LOAG_16104   glyceraldehyde 3-phosphate dehydrogenase
Loa Loa (eye worm) LOAG_12052   glyceraldehyde-3-phosphate dehydrogenase
Mycobacterium leprae ML0570   Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)
Mus musculus 100042025   predicted gene, 20899
Mus musculus ENSMUSG00000061099   glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
Mus musculus ENSMUSG00000057666   glyceraldehyde-3-phosphate dehydrogenase
Mycobacterium tuberculosis Rv1436   Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)
Mycobacterium ulcerans MUL_1828   glyceraldehyde 3-phosphate dehydrogenase Gap
Neospora caninum NCLIV_041940   Glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12), related
Neospora caninum NCLIV_037190   glyceraldehyde-3-phosphate dehydrogenase, putative
Oryza sativa 4329892   Os02g0601300
Oryza sativa 4331495   Os03g0129300
Oryza sativa 4344564   Os08g0126300
Oryza sativa 4341782   Os06g0666600
Oryza sativa 4336044   Os04g0459500
Oryza sativa 4328446   Os02g0171100
Oryza sativa 4336216   Os04g0486600
Plasmodium berghei PBANKA_1326400   glyceraldehyde-3-phosphate dehydrogenase
Plasmodium falciparum PF3D7_1462800   glyceraldehyde-3-phosphate dehydrogenase
Plasmodium knowlesi PKNH_1218700   glyceraldehyde-3-phosphate dehydrogenase, putative
Plasmodium vivax PVX_117322   glyceraldehyde-3-phosphate dehydrogenase, putative
Plasmodium yoelii PY03280   glyceraldehyde-3-phosphate dehydrogenase
Saccharomyces cerevisiae YGR192C   glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3
Saccharomyces cerevisiae YJL052W   glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1
Saccharomyces cerevisiae YJR009C   glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2
Schistosoma japonicum Sjp_0025800   ko:K00134 glyceraldehyde 3-phosphate dehydrogenase [EC1.2.1.12], putative
Schistosoma mansoni Smp_056970.2   glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
Schistosoma mansoni Smp_056970.4   glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
Schistosoma mansoni Smp_056970.3   glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
Schistosoma mansoni Smp_056970.1   glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
Schmidtea mediterranea mk4.004748.00   Glyceraldehyde-3-phosphate dehydrogenase
Schmidtea mediterranea mk4.002051.00   Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Schmidtea mediterranea mk4.001021.01   Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Schmidtea mediterranea mk4.000484.08   Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Schmidtea mediterranea mk4.000238.07   Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Schmidtea mediterranea mk4.000238.04   Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Trypanosoma brucei gambiense Tbg972.10.8410   glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative
Trypanosoma brucei gambiense Tbg972.6.4110   glyceraldehyde 3-phosphate dehydrogenase, glycosomal
Trypanosoma brucei gambiense Tbg972.6.4080   glyceraldehyde 3-phosphate dehydrogenase, glycosomal
Trypanosoma brucei Tb927.10.6880   glyceraldehyde 3-phosphate dehydrogenase, cytosolic
Trypanosoma brucei Tb927.6.4280   glyceraldehyde 3-phosphate dehydrogenase, glycosomal
Trypanosoma brucei Tb927.6.4300   glyceraldehyde 3-phosphate dehydrogenase, glycosomal
Trypanosoma congolense TcIL3000_10_5910   glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative
Trypanosoma congolense TcIL3000_0_36950   glyceraldehyde 3-phosphate dehydrogenase, glycosomal
Trypanosoma congolense TcIL3000_0_05050   glyceraldehyde 3-phosphate dehydrogenase, glycosomal
Trypanosoma cruzi TcCLB.506943.60   glyceraldehyde 3-phosphate dehydrogenase, putative
Trypanosoma cruzi TcCLB.509065.70   glyceraldehyde 3-phosphate dehydrogenase, putative
Trypanosoma cruzi TcCLB.506943.50   glyceraldehyde 3-phosphate dehydrogenase, putative
Trypanosoma cruzi TcCLB.509065.60   glyceraldehyde 3-phosphate dehydrogenase, putative
Trypanosoma cruzi TcCLB.510105.230   glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative
Trypanosoma cruzi TcCLB.510187.60   glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative
Trypanosoma cruzi TcCLB.509717.80   glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative
Toxoplasma gondii TGME49_289690   glyceraldehyde-3-phosphate dehydrogenase GAPDH1
Toxoplasma gondii TGME49_269190   glyceraldehyde-3-phosphate dehydrogenase GAPDH2
Treponema pallidum TP0844   glyceraldehyde 3-phosphate dehydrogenase (gap)
Theileria parva TP04_0383   glyceraldehyde-3-phosphate dehydrogenase, putative
Theileria parva TP02_0858   glyceraldehyde-3-phosphate dehydrogenase, putative
Trichomonas vaginalis TVAG_366380   glyceraldehyde 3-phosphate dehydrogenase, putative
Trichomonas vaginalis TVAG_412780   glyceraldehyde 3-phosphate dehydrogenase, putative
Trichomonas vaginalis TVAG_146910   glyceraldehyde 3-phosphate dehydrogenase, putative
Trichomonas vaginalis TVAG_475220   glyceraldehyde 3-phosphate dehydrogenase, putative
Trichomonas vaginalis TVAG_347410   glyceraldehyde 3-phosphate dehydrogenase, putative
Trichomonas vaginalis TVAG_476100   glyceraldehyde 3-phosphate dehydrogenase, putative
Trichomonas vaginalis TVAG_193800   glyceraldehyde 3-phosphate dehydrogenase, putative
Wolbachia endosymbiont of Brugia malayi Wbm0298   glyceraldehyde-3-phosphate dehydrogenase, GapA

Essentiality

PF3D7_1462800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.6880 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.6880 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.6880 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.6880 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.6.4280 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.6.4280 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.6.4280 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.6.4280 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b1779 Escherichia coli essential goodall
b2927 Escherichia coli non-essential goodall
CELE_T09F3.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_T09F3.3 Caenorhabditis elegans larval arrest wormbase
CELE_K10B3.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_K10B3.8 Caenorhabditis elegans larval arrest wormbase
CELE_K10B3.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_K10B3.7 Caenorhabditis elegans larval arrest wormbase
CELE_F33H1.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_F33H1.2 Caenorhabditis elegans larval arrest wormbase
PBANKA_1326400 Plasmodium berghei Essential plasmo
TGME49_289690 Toxoplasma gondii Probably essential sidik
TGME49_269190 Toxoplasma gondii Probably essential sidik
TGME49_289690 Toxoplasma gondii Probably non-essential sidik
TGME49_269190 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Plasmodium falciparum 559836  
Annotator: saralph@unimelb.edu.au. Comment: 012/Mar/09. References: 16131754 16345073

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

Compound Source Reference
Curated by TDRTargets References

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal Compounds References
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Compounds References
Leishmania mexicana glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Compounds References
Oryctolagus cuniculus Glyceraldehyde-3-phosphate dehydrogenase Compounds References
Homo sapiens glyceraldehyde-3-phosphate dehydrogenase Compounds References
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0429 0.4739 1
0.0152 0.3689 1
0.0066 0.3852 0.2182
0.17825 0.492593 0.489803
0.0205 0.2876 1
0.0477 0.26 0.3999
0.0164 1 0.5
0.0127521 0.312661 1
0.023 0.3145 1
0.0424 0.427 1
0.0145 0.628 0.5
0.0437 0.2563 1
0.1818 0.8093 1
0.0137 0.3869 0.7786
0.17825 0.492593 0.489803
0.0445 0.5118 0.5
0.0424 0.4231 1
0.0136545 0.29359 0.816199
0.0425 0.5004 1
0.0451 0.3718 1
0.0152 0.4969 0.8907
0.0063 0.3238 1
0.0182 0.5029 1
0.0424 0.5027 1
0.0404 0.5052 1
0.1741 0.7038 0.5
0.1882 0.8096 1
0.0427 0.3427 1
0.1758 0.7152 0.5
0.0437 0.2563 1
0.0291 1 0.5
0.0437 0.2563 1
0.0439 0.4265 1
0.1822 0.738 0.5
0.0132 0.3375 0.7641
0.012 0.2769 1
0.0071 0.3192 0.5
0.0112 0.5912 1
0.1901 0.896 1
0.0429 0.4241 1
0.1242 0.757 1
0.1828 0.7903 0.5
0.0202 1 0.5
0.0399 0.4841 1
0.0284 0.3098 0.6418
0.0457 0.3328 1
0.0422 0.4154 1
0.0477 0.2655 1
0.2055 0.7653 0.5
0.0067 0.3838 0.5
0.2208 0.7315 1
0.044 0.2565 1
0.0406 0.3228 1
0.2063 0.7829 0.5
0.0427 0.472 1
0.0517756 1 1
0.1347 0.6041 0.5
0.0443 0.3655 1
0.1636 0.824 0.5
0.036 0.4414 1
0.0531999 1 1
0.0203 1 0.5
0.0131 0.3919 0.7786
0.0103 0.2725 0.5
0.2121 1 0.5
0.2208 0.7315 1
0.0355 0.3218 1
0.0398 0.5049 1
0.2159 0.7355 1
0.0236 1 0.5
0.0353 0.3424 0.3038
0.023 0.3145 1
0.17825 0.492593 0.489803
0.0432 0.3929 1
0.0479 0.2955 1
0.2083 0.7886 0.5
0.0492 0.2674 0.9712
0.0315 1 0.5
0.0499 0.2673 0.6414
0.2076 0.4467 1
0.0246 0.5246 1
0.0067 0.4016 1
0.0424 0.4229 1
0.0443 0.2566 1
0.17825 0.492593 0.489803
0.038 0.3155 0.5
0.0464 1 0.5
0.0217 0.512 1
0.2131 0.8551 1
0.0385304 1 0.5
0.0371 0.4411 1
0.0429 0.423 1
0.0422 0.2542 1
0.1911 1 0.5
0.0292 0.9545 1
0.136 0.7375 1
0.17825 0.492593 0.489803
0.0318 0.3512 0.5
0.041 0.4991 1
0.0517756 1 1
0.028 1 1
0.1882 0.8096 1
0.196134 0.774293 1
0.1662 0.3906 1
0.194 0.7652 0.5
0.0445 0.3693 1
0.0425 0.258 1
0.0417 0.4204 1
0.17825 0.492593 0.489803
0.0135 1 0.5
0.0435 0.3903 1
0.0137 1 0.5
0.0129 0.2573 1
0.0155 1 0.5
0.0429 0.2744 1
0.0067 0.319 0.5
0.0263 0.5203 1
0.0139 0.3856 0.7786
0.0082 0.357 1
0.17825 0.492593 0.489803
0.0448 0.2563 1
0.2131 0.8551 1
0.0315 1 0.5
0.0142 1 0.5
0.17825 0.492593 0.489803
0.046 0.2642 1
0.0412 0.2513 1
0.0509 0.259 0.2713
0.0284 0.388 0.5
0.0436 0.4667 1
0.2113 0.6115 0.5
0.148 0.9787 0.5
0.0132306 0.499709 0.479573
0.007 0.2967 0.5
0.0124202 0.339434 0.497053
0.014 0.3919 0.4875
0.0266 0.3131 0.5
0.0448 0.2563 1
0.0266 0.2708 1
0.014 1 1
0.0163 0.9239 1
0.0145 0.628 0.5
0.0197 1 0.5
0.2131 0.8551 1
0.0076 0.292 0.5
0.0076 0.292 0.5
0.0531999 1 1
0.2037 0.6099 1
0.1907 0.5762 0.5
0.0291 1 0.5
0.199 0.5348 1
0.016 0.6036 0.5
0.2131 0.8551 1
0.2131 0.8551 1
0.0082 1 1
0.0286 1 0.5
0.0477 0.26 1
0.0217 1 0.5
0.0448 0.2568 1
0.0284 0.3098 0.6418
0.015 0.3653 0.5
0.0429 0.418 1
0.1598 0.7574 1
0.0451 0.3542 1
0.012 0.2769 1
0.044 0.4079 1
0.1757 0.7692 0.5
0.046 0.2641 1
0.0246 0.5246 1
0.0265 0.3497 1
0.0512 0.5 0.5
0.0229 0.8834 0.5
0.2088 0.8023 0.5
0.0317 1 0.5
0.17825 0.492593 0.489803
0.0224 1 0.5
0.0133162 1 0.5
0.0122 1 1
0.0499 0.2572 0.4277
0.1594 0.708 0.5
0.0481 0.26 0.3073
0.17825 0.492593 0.489803
0.0139 0.3919 0.7786
0.0127598 0.312661 0.284649
0.0437 0.2563 1
0.027 0.3283 1
0.0477 0.2629 1
0.0291 1 0.5
0.0067 1 0.5
0.2003 0.8225 1
0.0066 0.3503 1
0.0438 0.4054 1
0.0264 0.5651 0.5
0.007 0.3975 0.4203
0.0101 0.6365 1
0.1713 0.7291 0.5
0.0685 0.6957 1
0.0153 0.7609 1
0.0435 0.3903 1
0.0349528 1 0.5
0.044 0.4062 1
0.1855 0.8207 1
0.0477 0.2629 1
0.0435 0.4183 1
0.0465 0.2687 1
0.0271 0.2725 1
0.0066 0.2626 0.5
0.159 0.8104 1
0.0077 0.319 0.5
0.0353 0.3424 0.3038
0.0414 0.4945 1
0.0399 0.6332 1
0.0427 0.424 1
0.028074 1 0.5
0.0481 0.2653 0.4511
0.0138 0.9364 0.5
0.17825 0.492593 0.489803
0.0294 0.3377 1
0.0264 1 0.5
0.0131 0.349 1
0.2113 0.7256 0.5
0.0067 0.4016 0.4207
0.0124202 0.339434 0.497053
0.0407 1 0.5
0.17825 0.492593 0.489803
0.0164 1 0.5
0.0082 0.319 0.5
0.0438 0.4082 1
0.0429 0.424 1
0.0479 0.2955 1
0.0101 0.6365 1
0.0219 1 0.5
0.0143 0.3033 0.3006
0.0289 0.9796 1
0.0405 0.5015 1
0.1759 0.7779 0.5
0.0147063 1 0.5
0.0405 0.2513 1
0.0368 0.2547 1
0.0127598 0.312661 0.284649
0.0451 0.3722 1
0.0479 0.2626 1
0.0505 0.2625 0.2943
0.007 0.3192 1
0.0074 0.5832 1
0.0077 0.2664 0.5
0.0353 0.3424 0.3038
0.0131 0.3465 1
0.0069 0.2886 0.5
0.0284 0.3098 0.6418
0.2244 1 1
0.1795 0.7148 0.5
0.0457 0.3683 1
0.1662 0.3906 1
0.0448 0.3682 1
0.0432 0.3877 1
0.0188 0.4164 0.5
0.0286 0.3455 0.7216
0.199 0.5348 1
0.0483 0.2792 0.3406
0.1801 0.7298 0.5
0.0429 0.5013 1
0.0467 0.4455 0
0.0457 0.3771 1
0.0405 0.5049 1
0.0112 0.5912 1
0.0501 0.2546 0.3132
0.2148 0.7826 0.5
0.0143 0.2695 0.5
0.0451 0.3991 1
0.0187 1 1
0.0437 0.2623 1
0.0147 0.4402 1
0.0454 0.2627 1
0.0201 0.2626 0.5
0.0457 0.3759 1
0.0465 0.2687 1
0.0505 0.2538 0.2538
0.0355 0.3218 1
0.2125 0.291 1
0.0066 0.2505 1
0.0072 0.4193 1
0.021 0.6974 0.5
0.012 0.2769 1
0.0401 0.5024 1
0.2156 0.8485 1
0.2252 0.8573 0.5
0.0285 1 0.5
0.0356 0.4422 1
0.0221 1 0.5
0.0097 0.5031 1
0.186 1 0.5
0.0211 0.5995 0.5
0.0267 0.776 0.5
0.2108 0.8358 1
0.0219 0.2895 1
0.0266 0.2708 1
0.0435 0.2563 1
0.1598 0.7574 1
0.0143 1 1
0.0287 1 0.5
0.0129 0.2573 1
0.0407 0.505 1
0.0082 0.3192 1
0.0133 0.3733 0.7641
0.0401 0.4459 1
0.0291 1 0.5
0.0833 0.7224 0.5
0.0405 0.2518 1
0.0082 0.2751 0.5
0.0136 0.3855 0.7786
0.17825 0.492593 0.489803
0.2252 0.8573 0.5
0.0427 0.4521 1
0.0143 0.9545 0.5
0.0427 0.5026 1
0.0236 1 0.5
0.0451 0.263 1
0.0398 0.505 1
0.021 1 0.5
0.196134 0.774293 1
0.0427 0.4213 1
0.0443 0.3655 1
0.2089 0.712 1
0.0155 1 0.5
0.0437 0.3912 1
0.0082 0.2634 1
0.1636 0.8214 0.5
0.0425 0.5049 1
0.0077 0.4016 1
0.158 1 0.5
0.0135 0.3651 0.7623
0.0206 1 0.5
0.0097 0.3833 0
0.0424 0.4229 1
0.0213 1 0.5
0.0479 0.2599 1
0.2083 0.7779 0.5
0.0435 0.4677 1
0.199 0.5348 1
0.0437 0.2564 1
0.0068 0.3998 1
0.0137 0.2987 0.7786
0.136 0.7375 1
0.0432 0.5028 1
0.0127598 0.312661 0.284649
0.0074 0.3238 1
0.0066 0.4016 1
0.0477 0.2618 0.3998
0.0137 1 0.5
0.0141 0.2649 0.7743
0.136 0.7375 1
0.0368 0.2547 1
0.2131 0.8551 1
0.1598 0.7574 1
0.04 0.5007 1
0.021 0.4734 1
0.0246 0.5246 1
0.016 0.6036 0.5
0.1594 0.708 0.5
0.2112 0.811 1
0.0082 0.3083 1
0.04189 0.763682 0.5
0.0451 0.3774 1
0.0426 0.4855 1
0.0219 1 0.5
0.0429 0.465 1
0.0079 0.3554 0.7623
0.0236 1 0.5
0.0455 1 0.5
0.0428 0.2553 1
0.0427 0.3427 1
0.0444 1 1
0.044 0.3764 1
0.0308 1 0.5
0.0529 0.5747 1
0.0445 0.367 1
0.1941 0.7702 0.5
0.1662 0.3906 1
0.0133 0.358 1
0.0424 0.4219 1
0.0448 0.3746 1
0.0353 0.3424 0.3038
0.1882 0.8096 1

Assayability

Assay information

  • Assay for Glyceraldehyde-3-Phosphate Dehydrogenase from Bacillus (1.2.1.12 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.
  • ChEMBL
  • Inhibition of recombinant Plasmodium falciparum GAPDH expressed in Escherichia coli by time course assay
  • ChEMBL
  • Inhibition of recombinant Plasmodium falciparum GAPDH expressed in Escherichia coli at 50 to 200 uM by time course assay
  • ChEMBL
  • Irreversible inhibition of recombinant Plasmodium falciparum GAPDH expressed in Escherichia coli by time course assay
  • ChEMBL
  • Inhibition of recombinant Plasmodium falciparum GAPDH expressed in Escherichia coli assessed as ratio of kinact to Ki by Kitz-Wilson double-reciprocal plot
  • ChEMBL
  • Inhibition of recombinant His-tagged Plasmodium falciparum GAPDH expressed in Escherichia coli using sodium arseniate as substrate at 50 to 300 uM
  • ChEMBL
  • Slow phase inhibition of recombinant His-tagged Plasmodium falciparum GAPDH expressed in Escherichia coli using sodium arseniate as substrate assessed as ratio of Kinact to Ki by Kitz-Wilson double reciprocal plot analysis
  • ChEMBL
  • Fast phase inhibition of recombinant His-tagged Plasmodium falciparum GAPDH expressed in Escherichia coli using sodium arseniate as substrate assessed as ratio of Kinact to Ki by Kitz-Wilson double reciprocal plot analysis

Reagent availability

  • Pfal007254AAA;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Pfal007254; Recombinant protein: full-length; Source: P falciparum; glyceraldehyde-3-phosphate dehydrogenase ;

Bibliographic References

2 literature references were collected for this gene.

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Gene identifier PF3D7_1462800 (Plasmodium falciparum), glyceraldehyde-3-phosphate dehydrogenase
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