Detailed view for Smp_142960

Basic information

TDR Targets ID: 293023
Schistosoma mansoni, glutathione synthetase

Source Database / ID:  GeneDB

pI: 5.2649 | Length (AA): 781 | MW (Da): 87608 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00348   Polyprenyl synthetase
PF03199   Eukaryotic glutathione synthase
PF03917   Eukaryotic glutathione synthase, ATP binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004363   glutathione synthase activity  
GO:0003824   catalytic activity  
GO:0008299   isoprenoid biosynthetic process  
GO:0006750   glutathione biosynthetic process  

Metabolic Pathways

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
140 318 3aq0 (A) 19 200 25.00 0.000009 0.18 0.426993 -0.07
360 781 5oes (A) 64 483 31.00 0 1 0.683133 0.4
526 781 2hgs (A) 223 474 39.00 0 1 0.630885 1.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133417)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG10585   CG10585 gene product from transcript CG10585-RA
Echinococcus granulosus EgrG_000591700   prenyl decaprenyl diphosphate synthase
Echinococcus multilocularis EmuJ_000591700   prenyl (decaprenyl) diphosphate synthase
Homo sapiens ENSG00000164494   prenyl (decaprenyl) diphosphate synthase, subunit 2
Mus musculus ENSMUSG00000038240   prenyl (solanesyl) diphosphate synthase, subunit 2
Schistosoma japonicum Sjp_0302140   ko:K00805 trans-hexaprenyltranstransferase [EC2.5.1.30], putative
Schistosoma mansoni Smp_142960   glutathione synthetase
Schmidtea mediterranea mk4.000580.01   Decaprenyl-diphosphate synthase subunit 2

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0715 0.3347 0.334
0.0715 0.3347 0.334
0.0445 0.2829 0.2829
0.8614 0.2866 0.2866
0.0517 0.2702 0.2648
0.0498 0.3247 0.3247
0.3926 0.2756 0.2756
0.0679 0.2583 0.2583
0.0715 0.3347 0.334
0.1821 0.2575 0.257
0.0094 0.3186 0.3186
0.0433 0.267 0.267
0.0715 0.3347 0.334
0.0398 0.2674 0.2503
0.0494 0.29 0.264
0.0715 0.3347 0.334
0.8614 0.2866 0.2866
0.0693 0.2649 0.3073
0.0635 0.2606 0.2606
0.4173 0.2761 0.2761
0.0953 0.2702 0.2702
0.0436 0.3099 0.3099
0.0679 0.2583 0.2583
0.0377 0.2905 0.2896
0.047 0.2506 0
0.3926 0.2756 0.2756
0.0094 0.2984 0.264
0.1374 0.2627 0.2627
0.0128 0.288 0.288
0.7582 0.2936 0.2936
0.0498 0.3247 0.3247
0.0411 0.2525 0.2784
0.0679 0.2583 0.2583
0.0704 0.3928 0.3928
0.0693 0.2649 0.3073
0.0679 0.2583 0.2583
0.084 0.2579 0.2545
0.0169 0.3173 0.2587
0.0693 0.2649 0.3073
0.1063 0.2647 0.2639
0.0447 0.2832 0.2829
0.4054 0.2847 0.2847
0.8614 0.2866 0.2866
0.0679 0.2583 0.2583
0.05 0.2528 0.2478
0.0425 0.2773 0.2773
0.1063 0.2647 0.2639
0.0663 0.273 0.273
0.0693 0.2649 0.3073
0.0118 0.3145 0.3145
0.0433 0.267 0.267
0.0693 0.2649 0.3073
0.0706 0.2737 0.2737
0.026 0.2585 0.2585
0.0261 0.2812 0.2877
0.0425 0.2773 0.2773
0.1685 0.2666 0.2666
0.084 0.2579 0.2545
0.0332 0.2653 0.2653
0.0693 0.2649 0.3073
0.1179 0.3053 0.3053
0.0416 0.3269 0.2983
0.0254 0.2727 0.2727
0.0545 0.2666 0.2666
0.0583 0.3069 0.3069
0.0498 0.3247 0.3247
0.026 0.2585 0.2585
0.0693 0.2649 0.3073
0.0411 0.2525 0.2784
0.0327 0.2716 0.2716
0.0519 0.2681 0.2681
0.0788 0.2789 0.228
0.0425 0.2654 0.2506
0.0663 0.273 0.273
0.0673 0.2639 0.2638
0.0191 0.3456 0.336
0.0693 0.2649 0.3073
0.0448 0.2646 0.2508
0.0411 0.2525 0.2784

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_142960 (Schistosoma mansoni), glutathione synthetase
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