Detailed view for Smp_180760

Basic information

TDR Targets ID: 293191
Schistosoma mansoni, chondroitin sulfate proteoglycan-related
Source Database / ID:  GeneDB

pI: 6.6668 | Length (AA): 1481 | MW (Da): 169797 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00054   Laminin G domain
PF02210   Laminin G domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005509   calcium ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
38 1088 3qcw (A) 306 1321 27.00 0 1 0.809256 0.87
248 658 2jd4 (A) 2702 3029 21.00 0 1 0.153015 0.8
508 658 2r16 (A) 725 880 25.00 0 0.66 0.396458 -0.64
868 905 5l0v (B) 1 37 43.00 0.019 1 0.550258 -0.28
868 905 1fak (L) 46 82 41.00 0.7 1 0.529258 -0.27

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129550)

Species Accession Gene Product
Brugia malayi Bm1_11475   Thrombospondin N-terminal -like domain containing protein
Drosophila melanogaster Dmel_CG7050   Neurexin 1
Echinococcus granulosus EgrG_000236300   hypothetical protein
Echinococcus granulosus EgrG_000236200   neurexin 1 alpha
Echinococcus multilocularis EmuJ_000236300  
Homo sapiens ENSG00000179915   neurexin 1
Homo sapiens ENSG00000021645   neurexin 3
Homo sapiens ENSG00000110076   neurexin 2
Loa Loa (eye worm) LOAG_11885   hypothetical protein
Loa Loa (eye worm) LOAG_09116   hypothetical protein
Mus musculus ENSMUSG00000066392   neurexin III
Mus musculus ENSMUSG00000024109   neurexin I
Mus musculus ENSMUSG00000033768   neurexin II
Schistosoma japonicum Sjp_0132100   ko:K07377 neurexin, putative
Schistosoma japonicum Sjp_0009790   Neurexin-1-alpha precursor, putative
Schistosoma mansoni Smp_180760   chondroitin sulfate proteoglycan-related
Schmidtea mediterranea mk4.006239.01  
Schmidtea mediterranea mk4.009567.01  
Schmidtea mediterranea mk4.006239.00  
Schmidtea mediterranea mk4.024342.00   Chondroitin sulfate proteoglycan-related

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0025 0.3891 0.3891
0.0078 0.3631 0.2694
0.0277 0.3252 0.3252
0.0027 0.4212 0.6742
0.0023 0.5 0.5
0.0025 0.5 0.5
0.0077 1 1
0.0173 0.4278 0.4268
0.0115 0.3005 0.3005
0.0026 0.435 0.6964
0.0345 0.4313 0.4313
0.0028 0.5 0.5
0.0054 0.5 0.5
0.0078 0.3631 0.2694
0.0025 1 1
0.0027 0.4212 0.6742
0.0029 1 1
0.0218 0.3656 0.3656
0.0026 1 1
0.0046 0.3702 1
0.0049 0.2501 0.998
0.0218 0.3656 0.3656
0.0029 1 1
0.0024 0.5 0.5
0.0051 1 1
0.00203233 1 1
0.0027 1 1
0.0277 0.3252 0.3252
0.0028 0.5 0.5
0.0078 0.3631 0.2694

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_180760 (Schistosoma mansoni), chondroitin sulfate proteoglycan-related
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