Detailed view for Smp_155460

Basic information

TDR Targets ID: 293852
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 8.706 | Length (AA): 650 | MW (Da): 75653 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00373   FERM central domain
PF09379   FERM N-terminal domain
PF09380   FERM C-terminal PH-like domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005856   cytoskeleton  
GO:0005737   cytoplasm  
GO:0019898   extrinsic to membrane  
GO:0008092   cytoskeletal protein binding  
GO:0005488   binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
112 250 5ejy (A) 39 172 10.00 0.67 0 0.331946 -0.53
271 611 3pvl (A) 1231 1605 13.00 0 1 0.595815 0.42
295 579 6ibe (A) 107 388 52.00 0.000000000048 1 1.12456 -0.81
297 636 4rm8 (A) 4 567 24.00 0 1 0.814277 -0.31
297 541 2i1j (A) 4 258 33.00 0 1 0.745023 -0.15
304 647 2i1j (A) 10 359 20.00 0.00061 1 0.786331 0.18
353 429 2az5 (A) 28 130 38.00 0.71 0.09 0.144562 1.76

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128746)

Species Accession Gene Product
Brugia malayi Bm1_17150   hypothetical protein
Caenorhabditis elegans CELE_ZK270.2   Protein FRM-1, isoform E
Drosophila melanogaster Dmel_CG11949   coracle
Echinococcus granulosus EgrG_000468600   protein 4.1
Echinococcus multilocularis EmuJ_000468600  
Homo sapiens ENSG00000079819   erythrocyte membrane protein band 4.1-like 2
Homo sapiens ENSG00000082397   erythrocyte membrane protein band 4.1-like 3
Homo sapiens ENSG00000159023   erythrocyte membrane protein band 4.1
Homo sapiens ENSG00000088367   erythrocyte membrane protein band 4.1-like 1
Loa Loa (eye worm) LOAG_05898   hypothetical protein
Loa Loa (eye worm) LOAG_05899   hypothetical protein
Mus musculus ENSMUSG00000027624   erythrocyte protein band 4.1-like 1
Mus musculus ENSMUSG00000024044   erythrocyte protein band 4.1-like 3
Mus musculus ENSMUSG00000028906   erythrocyte protein band 4.1
Mus musculus ENSMUSG00000019978   erythrocyte protein band 4.1-like 2
Onchocerca volvulus OVOC1460  
Schistosoma japonicum Sjp_0300810   ko:K06107 erythrocyte membrane protein band 4.1, putative
Schistosoma japonicum Sjp_0049960   Acetylcholine receptor subunit alpha-L1 precursor, putative
Schistosoma japonicum Sjp_0105520   expressed protein
Schistosoma mansoni Smp_155470   hypothetical protein
Schistosoma mansoni Smp_155460   hypothetical protein
Schmidtea mediterranea mk4.003868.00   Protein 4.1 homolog
Schmidtea mediterranea mk4.004252.01   Putative 4.1 G protein
Schmidtea mediterranea mk4.008770.02   Putative 4.1 G protein
Schmidtea mediterranea mk4.012491.01  
Trichomonas vaginalis TVAG_387960   conserved hypothetical protein

Essentiality

Smp_155460 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_ZK270.2 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_155460 (Schistosoma mansoni), hypothetical protein
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