pI: 6.0814 |
Length (AA): 736 |
MW (Da): 83438 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
35 | 669 | 4ry2 (A) | 89 | 708 | 23.00 | 0 | 1 | 0.970072 | 1.07 |
85 | 717 | 4f4c (A) | 41 | 738 | 20.00 | 0 | 1 | 1.01225 | 0.91 |
419 | 684 | 5idv (A) | 17 | 277 | 35.00 | 0 | 1 | 0.855613 | -0.81 |
441 | 682 | 5eum (A) | 341 | 584 | 35.00 | 0 | 1 | 0.853004 | -1.01 |
441 | 717 | 3gd7 (A) | 1204 | 1484 | 33.00 | 0 | 1 | 0.822559 | -0.53 |
444 | 680 | 3vx4 (A) | 525 | 760 | 28.00 | 0 | 1 | 0.789211 | -1.14 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126561)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G13100 | ABC transporter C family member 7 |
Arabidopsis thaliana | AT2G47800 | ABC transporter C family member 4 |
Arabidopsis thaliana | AT3G62700 | ABC transporter C family member 14 |
Arabidopsis thaliana | AT1G30420 | ABC transporter C family member 11 |
Arabidopsis thaliana | AT1G30410 | multidrug resistance-associated protein 13 |
Arabidopsis thaliana | AT3G59140 | multidrug resistance-associated protein 14 |
Arabidopsis thaliana | AT1G30400 | glutathione S-conjugate transporting ATPase |
Arabidopsis thaliana | AT3G60970 | putative ABC transporter C-15 |
Arabidopsis thaliana | AT2G34660 | ABC transporter C family member 2 |
Arabidopsis thaliana | AT3G21250 | multidrug resistance-associated protein 6 |
Arabidopsis thaliana | AT3G13080 | ABC transporter C family member 3 |
Arabidopsis thaliana | AT2G07680 | multidrug resistance-associated protein 11 |
Arabidopsis thaliana | AT1G04120 | inositol hexakisphosphate transporter |
Arabidopsis thaliana | AT3G60160 | multidrug resistance-associated protein 9 |
Arabidopsis thaliana | AT3G13090 | multidrug resistance-associated protein 8 |
Babesia bovis | BBOV_III005820 | ABC transporter family protein |
Babesia bovis | BBOV_III006450 | ABC transporter family protein |
Babesia bovis | BBOV_III005570 | ABC transporter family protein |
Babesia bovis | BBOV_I003180 | ABC transporter, ATP-binding protein domain containing protein |
Brugia malayi | Bm1_43555 | ABC transporter transmembrane region family protein |
Brugia malayi | Bm1_06395 | multidrug resistance related protein 1 |
Candida albicans | CaO19.6383 | one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) |
Candida albicans | CaO19.6382 | one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) |
Candida albicans | CaO19_6478 | hypothetical protein |
Candida albicans | CaO19.12566 | vacuolar ABC transporter similar to multiple drug resistance-associated protein |
Candida albicans | CaO19.13740 | one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) |
Candida albicans | CaO19.5100 | vacuolar ABC transporter similar to multiple drug resistance-associated protein |
Candida albicans | CaO19.13739 | one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) |
Candida albicans | CaO19.6478 | similar to vacuolar membrane ATP-dependant transporter, metal resistance protein |
Candida albicans | CaO19.13832 | similar to vacuolar membrane ATP-dependant transporter, metal resistance protein |
Caenorhabditis elegans | CELE_F57C12.4 | Protein MRP-2 |
Caenorhabditis elegans | CELE_F21G4.2 | Protein MRP-4 |
Caenorhabditis elegans | CELE_F20B6.3 | Protein MRP-6 |
Caenorhabditis elegans | CELE_Y43F8C.12 | Protein MRP-7 |
Caenorhabditis elegans | CELE_Y75B8A.26 | Protein MRP-8 |
Caenorhabditis elegans | CELE_E03G2.2 | Protein MRP-3 |
Caenorhabditis elegans | CELE_F57C12.5 | Protein MRP-1, isoform D |
Caenorhabditis elegans | CELE_F14F4.3 | Protein MRP-5, isoform A |
Cryptosporidium hominis | Chro.70499 | SI:dZ52I16.4 (novel ABC transporter similar to human multidrug-resistance proteins (MRP)) |
Cryptosporidium parvum | cgd7_4520 | ABC ATpase (2 ABC domains) with 10 transmembrane domains, adjacent duplicated gene |
Cryptosporidium parvum | cgd1_700 | ATP-binding cassette protein |
Dictyostelium discoideum | DDB_G0280055 | ABC transporter C family protein |
Dictyostelium discoideum | DDB_G0286559 | ABC transporter C family protein |
Dictyostelium discoideum | DDB_G0291243 | ABC transporter C family protein |
Dictyostelium discoideum | DDB_G0280541 | ABC transporter C family protein |
Dictyostelium discoideum | DDB_G0287691 | ABC transporter C family protein |
Dictyostelium discoideum | DDB_G0280973 | ABC transporter C family protein |
Dictyostelium discoideum | DDB_G0285165 | ABC transporter C family protein |
Dictyostelium discoideum | DDB_G0287593 | ABC transporter C family protein |
Dictyostelium discoideum | DDB_G0280977 | ABC transporter C family protein |
Dictyostelium discoideum | DDB_G0284867 | ABC transporter C family protein |
Dictyostelium discoideum | DDB_G0280539 | ABC transporter C family protein |
Dictyostelium discoideum | DDB_G0280459 | ABC transporter C family protein |
Dictyostelium discoideum | DDB_G0287589 | ABC transporter C family protein |
Drosophila melanogaster | Dmel_CG10505 | CG10505 gene product from transcript CG10505-RA |
Drosophila melanogaster | Dmel_CG5789 | CG5789 gene product from transcript CG5789-RA |
Drosophila melanogaster | Dmel_CG11898 | CG11898 gene product from transcript CG11898-RB |
Drosophila melanogaster | Dmel_CG31793 | CG31793 gene product from transcript CG31793-RC |
Drosophila melanogaster | Dmel_CG7806 | CG7806 gene product from transcript CG7806-RA |
Drosophila melanogaster | Dmel_CG31792 | CG31792 gene product from transcript CG31792-RC |
Drosophila melanogaster | Dmel_CG14709 | Multidrug resistance protein 4 ortholog |
Drosophila melanogaster | Dmel_CG6214 | Multidrug-Resistance like Protein 1 |
Drosophila melanogaster | Dmel_CG9270 | CG9270 gene product from transcript CG9270-RC |
Drosophila melanogaster | Dmel_CG8799 | lethal (2) 03659 |
Drosophila melanogaster | Dmel_CG4562 | CG4562 gene product from transcript CG4562-RC |
Drosophila melanogaster | Dmel_CG7627 | CG7627 gene product from transcript CG7627-RB |
Drosophila melanogaster | Dmel_CG11897 | CG11897 gene product from transcript CG11897-RB |
Echinococcus granulosus | EgrG_000248800 | multidrug resistance associated protein 4 |
Echinococcus granulosus | EgrG_000592100 | multidrug resistance associated protein 1 |
Echinococcus granulosus | EgrG_000828700 | multidrug resistance associated protein 7 |
Entamoeba histolytica | EHI_134470 | ATP-binding cassette protein, putative |
Entamoeba histolytica | EHI_124840 | ABC transporter, putative |
Entamoeba histolytica | EHI_060870 | hypothetical protein |
Entamoeba histolytica | EHI_095820 | ATP-binding cassette protein, putative |
Entamoeba histolytica | EHI_100320 | multidrug resistance protein, putative |
Entamoeba histolytica | EHI_178050 | ATP-binding cassette protein, putative |
Entamoeba histolytica | EHI_178580 | ATP-binding cassette protein, putative |
Echinococcus multilocularis | EmuJ_000248800 | multidrug resistance associated protein 4 |
Echinococcus multilocularis | EmuJ_000828700 | multidrug resistance associated protein 7 |
Echinococcus multilocularis | EmuJ_000592100 | multidrug resistance associated protein 1 |
Giardia lamblia | GL50803_115052 | Multidrug resistance-associated protein 1 |
Giardia lamblia | GL50803_28379 | Multidrug resistance-associated protein 1 |
Giardia lamblia | GL50803_17132 | MRP-like ABC transporter |
Giardia lamblia | GL50803_221689 | ABC transporter, putative |
Giardia lamblia | GL50803_41118 | Multidrug resistance-associated protein 1 |
Homo sapiens | 101930322 | multidrug resistance-associated protein 6-like |
Homo sapiens | ENSG00000140798 | ATP-binding cassette, sub-family C (CFTR/MRP), member 12 |
Homo sapiens | ENSG00000124574 | ATP-binding cassette, sub-family C (CFTR/MRP), member 10 |
Homo sapiens | ENSG00000006071 | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 |
Homo sapiens | ENSG00000125257 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 |
Homo sapiens | ENSG00000023839 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
Homo sapiens | ENSG00000114770 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 |
Homo sapiens | ENSG00000108846 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 |
Homo sapiens | ENSG00000069431 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 |
Homo sapiens | ENSG00000121270 | ATP-binding cassette, sub-family C (CFTR/MRP), member 11 |
Homo sapiens | ENSG00000103222 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
Leishmania braziliensis | LbrM.23.0230 | multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative |
Leishmania braziliensis | LbrM.31.1510 | p-glycoprotein e, putative |
Leishmania braziliensis | LbrM.23.0280 | ABC-thiol transporter |
Leishmania braziliensis | LbrM.31.1500 | p-glycoprotein e |
Leishmania braziliensis | LbrM.23.0740 | multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative |
Leishmania donovani | LdBPK_311460.1 | pentamidine resistance protein 1 |
Leishmania infantum | LinJ.23.0290 | ABC-thiol transporter |
Leishmania infantum | LinJ.31.1460 | pentamidine resistance protein 1 |
Leishmania infantum | LinJ.31.1290 | p-glycoprotein e |
Leishmania infantum | LinJ.23.0230 | ATP-binding cassette protein subfamily C, member 1, putative |
Leishmania infantum | LinJ.31.1300 | ATP-binding cassette protein subfamily C, member 5, putative |
Leishmania infantum | LinJ.31.1310 | ATP-binding cassette protein subfamily C, member 6, putative |
Leishmania infantum | LinJ.23.0240 | ATP-binding cassette protein subfamily C, member 2, putative |
Leishmania major | LmjF.31.1430 | pentamidine resistance protein 1 |
Leishmania major | LmjF.23.0220 | ATP-binding cassette protein subfamily C, member 2, putative |
Leishmania major | LmjF.23.0210 | ATP-binding cassette protein subfamily C, member 1, putative |
Leishmania major | LmjF.23.0250 | ABC-thiol transporter |
Leishmania major | LmjF.31.1280 | ATP-binding cassette protein subfamily C, member 5, putative |
Leishmania major | LmjF.31.1270 | p-glycoprotein e |
Leishmania major | LmjF.31.1290 | ATP-binding cassette protein subfamily C, member 6, putative |
Leishmania mexicana | LmxM.30.1430 | p-glycoprotein-like protein |
Leishmania mexicana | LmxM.30.1270 | p-glycoprotein e |
Leishmania mexicana | LmxM.30.1280 | p-glycoprotein e, putative |
Leishmania mexicana | LmxM.23.0220 | multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative |
Leishmania mexicana | LmxM.23.0250 | ABC-thiol transporter |
Leishmania mexicana | LmxM.23.0210 | ATP-binding cassette protein subfamily C, member 1, putative |
Leishmania mexicana | LmxM.30.1290 | multidrug resistance protein, copy 1-like protein |
Loa Loa (eye worm) | LOAG_09103 | hypothetical protein |
Loa Loa (eye worm) | LOAG_00362 | hypothetical protein |
Loa Loa (eye worm) | LOAG_02727 | hypothetical protein |
Loa Loa (eye worm) | LOAG_05713 | multidrug resistance-associated protein |
Loa Loa (eye worm) | LOAG_09104 | ABC transporter transmembrane region family protein |
Mus musculus | ENSMUSG00000036872 | ATP-binding cassette, sub-family C (CFTR/MRP), member 12 |
Mus musculus | ENSMUSG00000025194 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
Mus musculus | ENSMUSG00000032842 | ATP-binding cassette, sub-family C (CFTR/MRP), member 10 |
Mus musculus | ENSMUSG00000023088 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
Mus musculus | ENSMUSG00000022822 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 |
Mus musculus | ENSMUSG00000030249 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 |
Mus musculus | ENSMUSG00000030834 | ATP-binding cassette, sub-family C (CFTR/MRP), member 6 |
Mus musculus | ENSMUSG00000032849 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 |
Mus musculus | ENSMUSG00000040136 | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 |
Mus musculus | ENSMUSG00000020865 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 |
Neospora caninum | NCLIV_009810 | hypothetical protein |
Oryza sativa | 4331585 | Os03g0142800 |
Oryza sativa | 4338040 | Os05g0196100 |
Oryza sativa | 4340195 | Os06g0158900 |
Oryza sativa | 4335177 | Os04g0209300 |
Oryza sativa | 4327122 | Os01g0173900 |
Oryza sativa | 4336809 | Os04g0588600 |
Oryza sativa | 9267441 | Os06g0561800 |
Oryza sativa | 4336810 | Os04g0588700 |
Oryza sativa | 4340331 | Os06g0184700 |
Oryza sativa | 9266691 | Os01g0902100 |
Oryza sativa | 4329047 | Os02g0288400 |
Oryza sativa | 4337027 | Os04g0620000 |
Oryza sativa | 4349819 | Os11g0155600 |
Oryza sativa | 9272039 | Os02g0288733 |
Oryza sativa | 4352527 | Os12g0562700 |
Oryza sativa | 4326284 | Os01g0356000 |
Oryza sativa | 4335176 | Os04g0209200 |
Saccharomyces cerevisiae | YDR135C | ATP-binding cassette glutathione S-conjugate transporter YCF1 |
Saccharomyces cerevisiae | YLL048C | bile acid-transporting ATPase YBT1 |
Saccharomyces cerevisiae | YGR281W | ATP-binding cassette transporter YOR1 |
Saccharomyces cerevisiae | YKR103W | putative multidrug transporter NFT1 |
Saccharomyces cerevisiae | YHL035C | putative ATP-binding cassette multidrug transporter VMR1 |
Saccharomyces cerevisiae | YLL015W | ATP-binding cassette bilirubin transporter BPT1 |
Schistosoma japonicum | Sjp_0028030 | Canalicular multispecific organic anion transporter 2, putative |
Schistosoma japonicum | Sjp_0028040 | ko:K05667 ATP-binding cassette, subfamily C (CFTR/MRP), member 3, putative |
Schistosoma japonicum | Sjp_0027990 | Multidrug resistance-associated protein 1, putative |
Schistosoma japonicum | Sjp_0088380 | Multidrug resistance-associated protein 4, putative |
Schistosoma japonicum | Sjp_0107410 | Multidrug resistance-associated protein 4, putative |
Schistosoma japonicum | Sjp_0094160 | ko:K05674 ATP-binding cassette, subfamily C (CFTR/MRP), member 10, putative |
Schistosoma japonicum | Sjp_0121150 | Multidrug resistance-associated protein 4, putative |
Schistosoma japonicum | Sjp_0031710 | Multidrug resistance-associated protein 7, putative |
Schistosoma mansoni | Smp_147250.1 | multidrug resistance protein |
Schistosoma mansoni | Smp_171740 | multidrug resistance protein |
Schistosoma mansoni | Smp_167610 | multidrug resistance protein |
Schistosoma mansoni | Smp_147250.2 | multidrug resistance protein |
Schmidtea mediterranea | mk4.008607.03 | |
Schmidtea mediterranea | mk4.005098.02 | Multidrug resistance-associated protein 4 |
Schmidtea mediterranea | mk4.000143.09 | |
Schmidtea mediterranea | mk4.013166.00 | |
Schmidtea mediterranea | mk4.000271.06 | Multidrug resistance-associated protein 7 |
Schmidtea mediterranea | mk4.000143.19 | |
Schmidtea mediterranea | mk4.006999.00 | |
Schmidtea mediterranea | mk4.012239.00 | |
Schmidtea mediterranea | mk4.008607.04 | Multidrug resistance-associated protein 4 |
Schmidtea mediterranea | mk4.004048.07 | |
Schmidtea mediterranea | mk4.001002.08 | Putative multidrug resistance protein 1 |
Schmidtea mediterranea | mk4.000458.08 | |
Schmidtea mediterranea | mk4.004048.03 | |
Schmidtea mediterranea | mk4.004048.04 | |
Schmidtea mediterranea | mk4.001002.10 | |
Schmidtea mediterranea | mk4.000271.05 | Putative multidrug resistance associated protein |
Schmidtea mediterranea | mk4.001764.05 | |
Schmidtea mediterranea | mk4.013299.00 | |
Schmidtea mediterranea | mk4.007630.00 | |
Schmidtea mediterranea | mk4.000458.09 | |
Schmidtea mediterranea | mk4.005014.01 | |
Schmidtea mediterranea | mk4.004048.01 | |
Schmidtea mediterranea | mk4.000143.17 | |
Schmidtea mediterranea | mk4.000143.11 | Multidrug-Resistance like protein 1 |
Schmidtea mediterranea | mk4.004048.02 | |
Schmidtea mediterranea | mk4.002389.08 | Multidrug-Resistance like protein 1 |
Schmidtea mediterranea | mk4.013299.01 | |
Schmidtea mediterranea | mk4.000143.18 | |
Schmidtea mediterranea | mk4.018402.00 | |
Schmidtea mediterranea | mk4.001764.06 | |
Schmidtea mediterranea | mk4.000143.10 | |
Schmidtea mediterranea | mk4.007643.00 | |
Schmidtea mediterranea | mk4.010538.00 | Multidrug-Resistance like protein 1 |
Schmidtea mediterranea | mk4.000143.14 | |
Schmidtea mediterranea | mk4.001764.07 | |
Schmidtea mediterranea | mk4.004048.00 | |
Schmidtea mediterranea | mk4.006999.02 | |
Schmidtea mediterranea | mk4.000143.12 | Multidrug-Resistance like protein 1 |
Schmidtea mediterranea | mk4.002389.10 | Putative multidrug resistance protein 1 |
Schmidtea mediterranea | mk4.000458.07 | |
Schmidtea mediterranea | mk4.001002.09 | |
Schmidtea mediterranea | mk4.002389.09 | |
Schmidtea mediterranea | mk4.002389.07 | |
Schmidtea mediterranea | mk4.030652.00 | Multidrug resistance-associated protein 4 |
Trypanosoma brucei gambiense | Tbg972.4.2470 | multidrug resistance-associated protein, putative,p-glycoprotein |
Trypanosoma brucei gambiense | Tbg972.4.4600 | multidrug resistance protein E,p-glycoprotein |
Trypanosoma brucei | Tb927.8.2160 | p-glycoprotein |
Trypanosoma brucei | Tb927.4.4490 | multidrug resistance protein E |
Trypanosoma brucei | Tb11.v5.0734 | multidrug resistance-associated protein, putative |
Trypanosoma brucei | Tb927.4.2510 | multidrug resistance-associated protein, putative |
Trypanosoma congolense | TcIL3000_0_01290 | multidrug resistance protein A |
Trypanosoma congolense | TcIL3000_0_08390 | multidrug resistance-associated protein, putative |
Trypanosoma cruzi | TcCLB.508965.14 | multidrug resistance protein E, putative |
Trypanosoma cruzi | TcCLB.506559.100 | multidrug resistance-associated protein, putative |
Trypanosoma cruzi | TcCLB.510231.29 | multidrug resistance-associated protein, putative |
Trypanosoma cruzi | TcCLB.510785.10 | hypothetical protein |
Toxoplasma gondii | TGME49_320460 | ABC transporter transmembrane region domain-containing protein |
Theileria parva | TP02_0940 | ABC transporter, putative |
Theileria parva | TP04_0914 | ABC transporter, putative |
Theileria parva | TP02_0390 | ABC transporter, putative |
Theileria parva | TP03_0165 | ABC transporter, putative |
Theileria parva | TP02_0388 | ABC transporter, putative |
Theileria parva | TP01_0011 | ABC transporter, putative |
Theileria parva | TP02_0017 | ABC transporter, putative |
Theileria parva | TP03_0007 | ABC transporter, putative |
Theileria parva | TP02_0016 | ABC transporter, putative |
Theileria parva | TP02_0951 | ABC transporter, putative |
Theileria parva | TP02_0391 | ABC transporter, putative |
Theileria parva | TP03_0864 | ABC transporter, putative |
Theileria parva | TP04_0021 | ABC transporter, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.2160 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.2160 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.2160 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.8.2160 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.4.2510 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.2510 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.2510 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.4.2510 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.4.4490 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.4490 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.4490 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.4.4490 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F21G4.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F14F4.3 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F14F4.3 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_320460 | Toxoplasma gondii | Essentiality uncertain | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.