Detailed view for Smp_145190

Basic information

TDR Targets ID: 294104
Schistosoma mansoni, protein kinase
Source Database / ID:  GeneDB

pI: 6.4357 | Length (AA): 752 | MW (Da): 84650 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

Regulation of autophagy (KEGG)
mTOR signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 454 4rer (A) 13 543 22.00 0 1 0.703994 0.97
3 267 6fdy (U) 10 274 48.00 0 1 0.998094 -0.92
269 338 5fvk (A) 2 71 33.00 0 0.95 0.608685 -1.76

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127101)

Species Accession Gene Product
Arabidopsis thaliana AT2G37840   putative serine/threonine protein kinase ATG1c
Arabidopsis thaliana AT3G53930   autophagy-related protein 1b
Arabidopsis thaliana AT3G61960   protein kinase family protein
Brugia malayi Bm1_44665   Ser/Thr kinase.
Brugia malayi Bm1_38940   Protein kinase domain containing protein
Candida albicans CaO19.11322   likely protein kinase similar to S. cerevisiae ATG1 (YGL180W) protein kinase required for autophagy and cytoplasm-to-vacuole tar
Candida albicans CaO19.3841   likely protein kinase similar to S. cerevisiae ATG1 (YGL180W) protein kinase required for autophagy and cytoplasm-to-vacuole tar
Caenorhabditis elegans CELE_Y60A3A.1   Protein UNC-51
Dictyostelium discoideum DDB_G0292390   ULK family protein kinase
Drosophila melanogaster Dmel_CG10967   Autophagy-specific gene 1
Drosophila melanogaster Dmel_CG8866   CG8866 gene product from transcript CG8866-RA
Echinococcus granulosus EgrG_000854700   serine:threonine protein kinase ULK3
Echinococcus granulosus EgrG_001178500   serine:threonine protein kinase ULK2
Echinococcus multilocularis EmuJ_000854700   serine:threonine protein kinase ULK3
Echinococcus multilocularis EmuJ_001178500   serine:threonine protein kinase ULK2
Giardia lamblia GL50803_137719   Kinase, NEK
Homo sapiens ENSG00000140474   unc-51 like kinase 3
Homo sapiens ENSG00000083290   unc-51 like autophagy activating kinase 2
Homo sapiens ENSG00000177169   unc-51 like autophagy activating kinase 1
Loa Loa (eye worm) LOAG_11200   serine/threonine protein kinase
Loa Loa (eye worm) LOAG_14023   protein kinase domain-containing protein
Loa Loa (eye worm) LOAG_04357   ULK/ULK protein kinase
Mus musculus ENSMUSG00000004798   unc-51 like kinase 2
Mus musculus ENSMUSG00000029512   unc-51 like kinase 1
Mus musculus ENSMUSG00000032308   unc-51-like kinase 3
Neospora caninum NCLIV_058680   CBL-interacting protein kinase 25, related
Oryza sativa 4331441   Os03g0122000
Oryza sativa 9268534   Os03g0268200
Saccharomyces cerevisiae YGL180W   Atg1p
Schistosoma japonicum Sjp_0202780   ko:K08269 unc51-like kinase, putative
Schistosoma japonicum Sjp_0314440   expressed protein
Schistosoma japonicum Sjp_0049520   ko:K08269 unc51-like kinase, putative
Schistosoma mansoni Smp_157350   protein kinase
Schistosoma mansoni Smp_145190   protein kinase
Schmidtea mediterranea mk4.009604.00  
Schmidtea mediterranea mk4.012129.01  
Schmidtea mediterranea mk4.016886.00  
Toxoplasma gondii TGME49_316150   ULK kinase
Trichomonas vaginalis TVAG_074920   CAMK family protein kinase

Essentiality

Smp_145190 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
YGL180W Saccharomyces cerevisiae inviable yeastgenome
TGME49_316150 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens unc-51 like kinase 3 Compounds References
Homo sapiens unc-51 like autophagy activating kinase 1 Compounds References
Mus musculus unc-51-like kinase 3 Compounds References
Homo sapiens unc-51 like autophagy activating kinase 2 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 28.9% 266 aa Compounds References
Patiria pectinifera Cdc2 300 aa 30.4% 280 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 30.6% 288 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 28.0% 311 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 31.1% 280 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 33.1% 163 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 29.0% 279 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 27.3% 308 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0039 0.5 0.5
0.0062 0.6935 0.7231
0.0056 1 1
0.0033 0.5 0.5
0.0016 0.5 0.5
0.0042 0.5 0.5
0.0039 0.9485 1
0.0032 0.5 0.5
0.0092 1 1
0.0012 0.5 0.5
0.0008 0.5 0.5
0.0059 1 1
0.0093 0.8828 0
0.0063 0.7244 0
0.0029 0.5 0.5
0.0345 0.2761 0.3289
0.0067 0.5 0.5
0.0023 0.5 0.5
0.0645 0.2662 0.314
0.0428 0.2821 0.3362
0.0428 0.2925 0.3455
0.0061 0.6883 0.6656
0.0345 0.2761 0.3289
0.0036 0.5 0.5
0.0091 1 1
0.0037 1 0.5
0.0639 0.2515 0.3127
0.0012 0.5 0.5
0.0039 0.5 0.5
0.0011 1 1
0.0022 0.5 0.5
0.0032 0.5 0.5
0.0063 1 1
0.0004 0.5 0.5
0.0343 0.2925 0.3464
0.0012 0.5 0.5
0.0027 1 1
0.0367726 0.294176 0.370372
0.0081 0.5 0.5
0.0016 0.5 0.5
0.0069 0.3067 0.3067
0.0059 1 1
0.0018 0.5 0.5
0.0007 0.5 0.5
0.0656 0.2688 0.3179
0.0098 0.3242 0.2614
0.0066 0.3101 0.9479
0.0007 0.5 0.5
0.0081 1 1
0.0064 0.3377 0.9531
0.0428 0.2925 0.3455
0.0026 0.5 0.5
0.0007 0.5 0.5
0.0059 1 1
0.0003 0.5 0.5
0.0088 0.4477 0.6337
0.0033 1 1
0.0428 0.2925 0.3455

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_145190 (Schistosoma mansoni), protein kinase
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