Detailed view for Smp_166620

Basic information

TDR Targets ID: 294230
Schistosoma mansoni, calcium-activated potassium channel
Source Database / ID:  GeneDB

pI: 8.4731 | Length (AA): 646 | MW (Da): 74150 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03493   Calcium-activated BK potassium channel alpha subunit
PF07885   Ion channel

Gene Ontology

Mouse over links to read term descriptions.
GO:0060072   large conductance calcium-activated potassium channel activity  
GO:0016020   membrane  
GO:0005488   binding  
GO:0003824   catalytic activity  
GO:0015269   calcium-activated potassium channel activity  
GO:0006813   potassium ion transport  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 115 3beh (A) 114 214 19.00 0 0.12 0.354791 -0.33
27 127 3eff (K) 32 126 18.00 0 0.05 0.256147 0.11
62 103 1izl (D) 66 122 40.00 0.68 0.08 0.192615 2.71
122 642 3naf (A) 332 885 28.00 0 1 1.0073 0.58
126 639 3naf (A) 336 882 31.00 0 1 1.03527 0.41
132 646 4hpf (A) 331 874 32.00 0 1 0.826814 0.91

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130388)

Species Accession Gene Product
Brugia malayi Bm1_07560   Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog
Caenorhabditis elegans CELE_Y51A2D.19   Protein SLO-1, isoform M
Dictyostelium discoideum DDB_G0282291   calcium-activated BK potassium channel, alpha subunit family protein
Dictyostelium discoideum DDB_G0269896   calcium-activated BK potassium channel, alpha subunit
Drosophila melanogaster Dmel_CG10693   slowpoke
Echinococcus granulosus EgrG_000583100   calcium activated potassium channel variant
Echinococcus granulosus EgrG_000135700   calcium activated potassium channel
Echinococcus granulosus EgrG_001146300   potassium large conductance calcium activated
Echinococcus multilocularis EmuJ_000583100   calcium activated potassium channel variant
Echinococcus multilocularis EmuJ_000135700   calcium activated potassium channel
Echinococcus multilocularis EmuJ_001146200   potassium large conductance calcium activated
Homo sapiens ENSG00000215262   potassium channel, subfamily U, member 1
Homo sapiens ENSG00000156113   potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Loa Loa (eye worm) LOAG_12897   large conductance calcium-activated potassium channel alpha subunit ai
Loa Loa (eye worm) LOAG_10097   MaxiK calcium-activated potassium channel
Loa Loa (eye worm) LOAG_16323   hypothetical protein
Mus musculus ENSMUSG00000063142   potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Mus musculus ENSMUSG00000031576   potassium channel, subfamily U, member 1
Schistosoma japonicum Sjp_0121990   expressed protein
Schistosoma japonicum Sjp_0074820   ko:K05390 potassium large conductance calcium-activated channel, subfamily M,, putative
Schistosoma japonicum Sjp_0310400   Calcium-activated potassium channel slo-1, putative
Schistosoma japonicum Sjp_0121550   IPR003929,Calcium-activated BK potassium channel, alpha subunit,domain-containing
Schistosoma mansoni Smp_166910   calcium-activated potassium channel
Schistosoma mansoni Smp_166620   calcium-activated potassium channel
Schmidtea mediterranea mk4.014189.00  
Schmidtea mediterranea mk4.010351.01   Calcium-activated potassium channel slo-1
Schmidtea mediterranea mk4.002479.00   Calcium-activated potassium channel slo-1
Schmidtea mediterranea mk4.000108.08   Calcium-activated potassium channel slo-1
Schmidtea mediterranea mk4.002611.07  
Schmidtea mediterranea mk4.012205.04   Calcium-activated potassium channel slo-1
Schmidtea mediterranea mk4.002611.05  
Schmidtea mediterranea mk4.002611.06  
Schmidtea mediterranea mk4.003838.00   Calcium-activated potassium channel slo-1
Schmidtea mediterranea mk4.018278.01  
Schmidtea mediterranea mk4.001241.00  
Schmidtea mediterranea mk4.018278.00  
Schmidtea mediterranea mk4.002610.00   Calcium-activated potassium channel slo-1
Schmidtea mediterranea mk4.002479.01  
Schmidtea mediterranea mk4.014381.01   Calcium-activated potassium channel slo-1
Schmidtea mediterranea mk4.021839.00   Calcium-activated potassium channel slo-1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Calcium-activated potassium channel subunit alpha-1 Compounds References
Homo sapiens potassium large conductance calcium-activated channel, subfamily M, alpha member 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0088 0.3487 0
0.00958956 0.561452 0.561452
0.0088 0.3487 0
0.0361 0.4267 0.4251
0.0407 0.5035 0.5807
0.0052 0.2609 0.2609
0.037 0.2653 0.2626
0.0043 0.9083 0.9047
0.0089 0.7916 0
0.0091 0.8962 0.8899
0.00390784 0.866046 0.866046
0.0273 0.7138 0.7138
0.0235 0.2674 0.7277
0.0219 0.3069 0.302
0.0042 0.7916 0.6452
0.0177 0.272 0.9231
0.0046 0.8871 0.8871
0.0218 0.2625 0.9247
0.0133 0.336 0.731
0.0089 0.57 0.57
0.0096 0.5226 0.5226
0.0047 0.8185 0
0.0089 0.8295 0.8295
0.0043 0.7916 0.5556
0.0052 0.7942 0.7942
0.0043 0.3573 0.1407
0.01945 0.76096 0.76096
0.013 0.3186 0.6065
0.0232 0.8193 0.926
0.0043 0.5565 0.5565

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_166620 (Schistosoma mansoni), calcium-activated potassium channel
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