Detailed view for Smp_150040.2

Basic information

TDR Targets ID: 294248
Schistosoma mansoni, serine/threonine protein kinase
Source Database / ID:  GeneDB

pI: 7.461 | Length (AA): 401 | MW (Da): 44927 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005675   holo TFIIH complex  
GO:0070985   GO:TFIIK complex  

GO:0008353   RNA polymerase subunit kinase activity  
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 401 6c9f (A) 12 547 24.00 0 1 1.09824 0.41
11 301 1ob3 (A) 1 286 40.00 0 1 1.23559 -0.76
14 345 1j1b (A) 56 381 32.00 0 1 1.20883 -0.57
15 315 1ua2 (A) 13 311 56.00 0 1 1.41552 -0.71

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129224)

Species Accession Gene Product
Arabidopsis thaliana AT1G73690   1
Arabidopsis thaliana AT1G18040   3
Arabidopsis thaliana AT1G66750   cyclin-dependent kinase D-2
Brugia malayi Bm1_14135   cyclin-dependent kinase 7 homolog
Candida albicans CaO19.6239   Serine-threonine kinase, subunit of RNA Pol TFIIK.
Candida albicans CaO19.13619   Serine-threonine kinase, subunit of RNA Pol TFIIK.
Caenorhabditis elegans CELE_Y39G10AL.3   Protein CDK-7
Dictyostelium discoideum DDB_G0285417   CDK family protein kinase
Drosophila melanogaster Dmel_CG3319   Cyclin-dependent kinase 7
Echinococcus granulosus EgrG_000804900   cyclin dependent kinase 7
Echinococcus multilocularis EmuJ_000804900   cyclin dependent kinase 7
Homo sapiens ENSG00000134058   cyclin-dependent kinase 7
Loa Loa (eye worm) LOAG_00613   CMGC/CDK/CDK7 protein kinase
Mus musculus ENSMUSG00000069089   cyclin-dependent kinase 7
Oryza sativa 4338689   Os05g0392300
Saccharomyces cerevisiae YDL108W   TFIIH complex serine/threonine-protein kinase subunit KIN28
Schistosoma japonicum Sjp_0204000   expressed protein
Schistosoma mansoni Smp_150040.2   serine/threonine protein kinase
Schistosoma mansoni Smp_150040.1   serine/threonine protein kinase
Schmidtea mediterranea mk4.005132.00   Putative cell division protein kinase

Essentiality

Smp_150040.2 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y39G10AL.3 Caenorhabditis elegans embryonic lethal wormbase
YDL108W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens cyclin-dependent kinase 7 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 36.7% 308 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 38.5% 301 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 40.5% 289 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 37.0% 308 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 27.1% 303 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 39.3% 191 aa Compounds References
Patiria pectinifera Cdc2 300 aa 37.3% 292 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 37.6% 290 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0153 0.4582 0.4582
0.0355 0.2645 0.2868
0.0059 1 1
0.0336 0.3594 0.3717
0.0094 0.4416 0.4405
0.0485 0.2929 0.2929
0.0433 0.3138 0.3138
0.0094 0.4016 0.4096
0.0066 0.3101 0.9479
0.0097 0.2597 0.2597
0.0004 0.5 0.5
0.0094 0.3998 0.3986
0.0255 0.2827 0.2911
0.0348 0.3004 0.3083
0.0081 0.3506 0.9538
0.0078 0.3506 0.9538
0.0408 0.2806 0.2786
0.0179 0.6146 0.8862
0.0039 0.9485 1
0.0353 0.2635 0.2862
0.0094 0.4539 0.4539
0.0322 0.3136 0.3133
0.043 0.2838 0.2838
0.0093 0.8828 0
0.0093 0.2663 0.3766
0.0094 0.2612 0.2612
0.009 0.2663 0.3766
0.0093 0.2663 0.3766
0.0439 0.3762 0.3902
0.0026 0.5 0.5
0.0093 0.2663 0.3766
0.0012 0.5 0.5
0.0093 0.5518 0.5518
0.0093 0.2663 0.3766
0.0027 1 1
0.0422 0.388 0.4032
0.0711 0.2736 0.271
0.0012 0.5 0.5
0.0067 0.5 0.5
0.0181 0.6075 0.8862
0.0391 0.3724 0.3724
0.0435 0.2957 0.2928
0.0748 0.2861 0.7352
0.0547 0.3497 0.3424
0.0405 0.2781 0.2781
0.0551625 0.499122 0.527797
0.0098 0.3242 0.2614
0.0011 1 1
0.0368 0.2676 0.2876
0.0859 0.2994 0.2994
0.0003 0.5 0.5
0.0255 0.2827 0.2911
0.0018 0.5 0.5
0.0093 0.2663 0.3766
0.0799 0.3309 0.3309
0.0419 0.2875 0.2875
0.0032 0.5 0.5
0.0093 0.2663 0.3766
0.0491 0.3494 0.3494
0.0086 0.2862 1
0.0256 0.2871 0.2909
0.0042 0.5 0.5
0.0093 0.2663 0.3766
0.0415 0.4031 0.4173
0.0093 0.2663 0.3766
0.0095 0.435 0.435
0.0077 0.4156 0.4253
0.0039 0.5 0.5
0.0033 0.5 0.5
0.0317 0.2931 0.4078
0.0181 0.6118 0.6118
0.0096 0.4808 0.3674
0.0337 0.2532 0.2694
0.0094 0.2718 1
0.0314 0.302 0.3075
0.0022 0.5 0.5
0.0832 0.3326 0.3326
0.0711 0.376 0.376
0.0037 1 0.5
0.0063 0.7244 0
0.009 0.2769 0.4064
0.0152 0.2663 0.3766
0.0608 0.3038 0.6028
0.0079 0.4548 0.9674
0.0318 0.455 0.455
0.0238 0.2762 0.4509
0.0551625 0.499122 0.527797
0.0032 0.5 0.5
0.0079 0.3506 0.9538
0.0419 0.4524 0.4524
0.066 0.2842 0.6397
0.0087 0.3007 0.5241
0.0428 0.281 0.281
0.0063 1 1
0.0316 0.4557 0.4956
0.1486 0.2693 0.2693
0.0077 0.3506 0.9538
0.0092 0.4893 0.4893
0.0252 0.3897 0.4085
0.0551625 0.499122 0.527797
0.0076 0.2736 0.1062
0.0094 0.2718 1
0.0075 0.2663 0.3766
0.0036 0.5 0.5
0.0096 0.4893 0.4893
0.0238 0.2762 0.4509
0.0033 1 1
0.0059 1 1
0.0016 0.5 0.5
0.0012 0.5 0.5
0.0093 0.2663 0.3766
0.0253 0.3912 0.4078
0.0093 0.2663 0.3766
0.0093 0.2663 0.3766
0.0164 0.2535 0.2943
0.0085 0.2537 0.4395
0.0894 0.3216 0.5817
0.0433 0.3138 0.3138
0.0431 0.3599 0.3599
0.0077 0.3506 0.9538
0.0255 0.2827 0.2911
0.0253 0.6541 0.6631
0.1109 0.3947 0.3947
0.0233 0.2663 0.3766
0.0333 0.296 0.2958
0.0429 0.372 0.3922
0.0432 0.2971 0.2942
0.0171 0.4481 0.4481
0.0094 0.4142 0.4036
0.0984 0.3017 0.6231
0.0093 0.2663 0.3766
0.0617 0.3311 0.6055
0.0432 0.3006 0.3006
0.0177 0.2769 1
0.0322 0.3136 0.3133
0.0551625 0.499122 0.527797
0.0093 0.2663 0.3766
0.0056 1 1
0.1486 0.2693 0.2693
0.0093 0.2663 0.3766
0.0953 0.2894 0.2894
0.0094 0.2791 1
0.0987 0.2546 0
0.0183 0.655 0.7823
0.0088 0.4477 0.6337
0.0081 1 1
0.0427 0.2923 0.2923
0.0096 0.2505 0.4548
0.0317 0.2931 0.4078
0.0093 0.2663 0.3766
0.0423 0.456 0.456
0.0062 0.6935 0.7231
0.0094 0.3762 0.3762
0.0368 0.2663 0.2884
0.0342 0.3665 0.3832
0.0242 0.2663 0.3766
0.1486 0.2693 0.2693
0.0093 0.2663 0.3766
0.0425 0.2903 0.2903
0.0069 0.3067 0.3067
0.1219 0.3139 0.3135
0.0393 0.2749 0.6384
0.0029 0.5 0.5
0.0093 0.2663 0.3766
0.0641 0.2549 0.2544
0.0984 0.3017 0.6231
0.0591 0.2516 0.7379
0.0627 0.2789 0.2786
0.0165 0.2663 0.3766
0.0087 0.2663 0.3766
0.0007 0.5 0.5
0.0491 0.3494 0.3494
0.0431 0.2783 0.2783
0.0093 0.2663 0.3766
0.067 0.2851 0.5468
0.0092 1 1
0.0984 0.3017 0.6231
0.0083 0.2736 0.1062
0.0433 0.2791 0.2791
0.0393 0.2749 0.6384
0.0081 0.5 0.5
0.0093 0.2663 0.3766
0.0023 0.5 0.5
0.0078 0.2535 0.97
0.0406 0.4363 0.4363
0.0092 0.4893 0.4893
0.0091 1 1
0.1045 0.3319 0.7088
0.0616 0.5452 0.5775
0.0156 0.2798 0.2572
0.1486 0.2693 0.2693
0.0388 0.2505 0.2505
0.0095 0.435 0.435
0.0094 0.4541 0.4541
0.0559 0.3504 0.3476
0.059 0.3158 0.6625
0.0094 0.5685 0.5685
0.0008 0.5 0.5
0.123 0.3628 0.3628
0.0016 0.5 0.5
0.01 0.2653 0.2653
0.0424 0.2723 0.2881
0.0076 0.2736 0.1062
0.0093 0.2663 0.3766
0.0093 0.2663 0.3766
0.0039 0.5 0.5
0.0177 0.4486 0.4486
0.0093 0.2663 0.3766
0.0681 0.2612 0.6358
0.0097 0.2597 0.2597
0.0714 0.3739 0.3721
0.0491 0.3494 0.3494
0.0007 0.5 0.5
0.018 0.3012 0.4406
0.0246 0.2657 0.2511
0.0079 0.3347 0.9636
0.0988 0.2935 0.2935
0.0334 0.3607 0.3711
0.0059 1 1
0.0393 0.2749 0.6384
0.0064 0.3377 0.9531
0.0061 0.6883 0.6656
0.0499 0.3973 0.3973
0.0007 0.5 0.5
0.0939 0.4266 0.7

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_150040.2 (Schistosoma mansoni), serine/threonine protein kinase
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