Detailed view for Smp_165440

Basic information

TDR Targets ID: 294300
Schistosoma mansoni, netrin receptor unc5
Source Database / ID:  GeneDB

pI: 6.0979 | Length (AA): 830 | MW (Da): 93139 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00531   Death domain
PF00791   ZU5 domain
PF13927   Immunoglobulin domain
PF17217   UPA domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005042   netrin receptor activity  
GO:0038007   GO:netrin-activated signaling pathway  

GO:0016021   integral to membrane  
GO:0005515   protein binding  
GO:0007165   signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
39 250 4v2a (A) 43 240 32.00 0 1 0.533522 0.39
40 259 2v9q (A) 68 264 33.00 0 1 0.48316 0.89
162 249 3knb (A) 7 95 31.00 0.56 1 0.502124 -0.79
164 233 2lvc (A) 11 79 35.00 0.4 1 0.495437 -1.04
184 239 1fhg (A) 66 123 45.00 0.17 1 0.50057 -0.46
185 231 3puc (A) 32 79 43.00 0.079 0.78 0.541727 -0.5
399 830 3g5b (A) 544 940 32.00 0 1 0.664282 0.15
735 830 2dbf (A) 2 90 21.00 0 0.89 0.344463 -1.51
753 830 4o6x (A) 2 85 21.00 0.006 0.91 0.413376 -1.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129284)

Species Accession Gene Product
Brugia malayi Bm1_31555   Immunoglobulin I-set domain containing protein
Caenorhabditis elegans CELE_B0273.4   Protein UNC-5, isoform A
Drosophila melanogaster Dmel_CG8166   CG8166 gene product from transcript CG8166-RB
Echinococcus granulosus EgrG_000069600   netrin receptor unc 5
Echinococcus multilocularis EmuJ_000069600   netrin receptor unc 5
Homo sapiens ENSG00000107731   unc-5 homolog B (C. elegans)
Homo sapiens ENSG00000182168   unc-5 homolog C (C. elegans)
Homo sapiens ENSG00000156687   unc-5 homolog D (C. elegans)
Homo sapiens ENSG00000113763   unc-5 homolog A (C. elegans)
Loa Loa (eye worm) LOAG_02525   immunoglobulin I-set domain-containing protein
Loa Loa (eye worm) LOAG_15378   hypothetical protein
Mus musculus ENSMUSG00000020099   unc-5 homolog B (C. elegans)
Mus musculus ENSMUSG00000063626   unc-5 homolog D (C. elegans)
Mus musculus ENSMUSG00000025876   unc-5 homolog A (C. elegans)
Mus musculus ENSMUSG00000059921   unc-5 homolog C (C. elegans)
Onchocerca volvulus OVOC4207   Netrin receptor homolog
Schistosoma japonicum Sjp_0080750   ko:K07521 netrin receptor unc-5, putative
Schistosoma japonicum Sjp_0098730   expressed protein
Schistosoma mansoni Smp_165440   netrin receptor unc5
Schmidtea mediterranea mk4.028347.00   Putative netrin receptor unc5
Schmidtea mediterranea mk4.019102.01   Putative netrin receptor unc5
Schmidtea mediterranea mk4.011227.02   Putative netrin receptor unc5
Schmidtea mediterranea mk4.028347.01  
Schmidtea mediterranea mk4.004578.00   Putative netrin receptor unc5
Schmidtea mediterranea mk4.011227.00  
Schmidtea mediterranea mk4.015711.00  
Schmidtea mediterranea mk4.024940.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0562 0.4719 0.4965
0.0194 0.659 0.659
0.02 0.4204 0.5017
0.0207 0.6335 0.6335
0.0209 0.5748 0
0.0248 0.2975 0.2736
0.0528 0.6521 0.6518
0.0044 0.3189 0.3172
0.0052 0.5 0.5
0.0146 0.2897 0.2897
0.0115 0.5076 0.5076
0.0238 0.364 0.3916
0.0052 0.5 0.5
0.0191 0.6362 0.63
0.0514 0.6489 0.6489
0.0536 0.334 0.6478
0.0258 0.2548 0.6445
0.0259 0.2845 0.2813
0.0026 1 0.5
0.0026 0.5 0.5
0.0126 0.5398 0.6179
0.0097 0.4851 0.2902
0.0035 0.8097 0.8084
0.0114 0.2528 0.2528
0.0052 0.5 0.5
0.0186 0.648 0.648
0.0058 0.2789 0.2604
0.0126 0.5117 0.5062
0.0844 0.359 0.3588
0.0576 0.6307 0
0.0093 0.2758 0.2669
0.0064 0.2527 0.3733
0.0844 0.359 0.3588
0.0788 0.6409 0.6409
0.0026 0.367 0.6472
0.0248 0.5901 0.567
0.0204 0.4903 0.4662
0.0546 0.3645 0.6493
0.0921 0.6522 0.6522
0.0127 0.6401 0.6401
0.0056 0.6413 0.6413
0.0194 0.6318 0.6195
0.0421 0.5003 0.6425
0.0286 0.3229 0.3229
0.005 0.6137 0.6137
0.0248 0.6391 0.6391
0.0159 0.6257 0.6257
0.0467 0.4298 0.6519
0.0482 0.5133 0.5132
0.0263 0.3923 0.6326
0.0177 0.3555 0.354
0.0174 0.5698 0.5698
0.0085 0.4475 0.4475
0.053 0.3214 0.3214
0.0528 0.6521 0.6518
0.0052 0.5 0.5
0.0671 0.6473 0
0.0052 0.5 0.5
0.0281 0.6404 0.6404
0.0788 0.6409 0.6409
0.0283 0.2568 0.2532
0.0093 0.2758 0.2669
0.0301 0.3235 0.3235
0.0035 0.5756 0.5756
0.0258 0.2548 0.6445
0.041 0.6463 0.6462
0.0432 0.4105 0.4104
0.0273 0.6065 0.6065
0.0066 0.5 0.5
0.0119 0.5819 0
0.0516 0.3551 0.3551
0.0701 0.648 0
0.03 0.6494 0.6494
0.041 0.6463 0.6462
0.0177 0.3555 0.354
0.0177 0.3555 0.354
0.0235 0.5904 0.5904
0.0421 0.5003 0.6425
0.0892 0.6112 0
0.0666 0.6271 0
0.0126 0.5398 0.6179
0.0046 0.2932 0.2932
0.0236 0.2561 0.302

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Smp_165440 (Schistosoma mansoni), netrin receptor unc5
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