Detailed view for Smp_000880.1

Basic information

TDR Targets ID: 294500
Schistosoma mansoni, ATP synthase lipid-binding protein-like protein
Source Database / ID:  GeneDB

pI: 9.5886 | Length (AA): 122 | MW (Da): 12852 | Paralog Number: 1

Signal peptide: N | GPI Anchor: Y | Predicted trans-membrane segments: 2

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00137   ATP synthase subunit C

Gene Ontology

Mouse over links to read term descriptions.
GO:0033177   proton-transporting two-sector ATPase complex, proton-transporting domain  
GO:0045263   proton-transporting ATP synthase complex, coupling factor F(o)  
GO:0015078   hydrogen ion transmembrane transporter activity  
GO:0015991   ATP hydrolysis coupled proton transport  
GO:0015986   ATP synthesis coupled proton transport  

Metabolic Pathways

Oxidative phosphorylation (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 108 2khm (A) 29 139 10.00 0.099 0.01 0.894252 -0.03
49 120 2xnd (J) 2 73 83.00 0 0.99 1.38736 1.23
52 120 5fl7 (K) 6 74 64.00 0 0.98 1.19177 1.03

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126818)

Species Accession Gene Product
Arabidopsis thaliana ArthMp094   ATPase subunit 9
Arabidopsis thaliana ArthCp009   ATPase III subunit
Arabidopsis thaliana AT2G07671   ATP synthase subunit C family protein
Babesia bovis BBOV_III004620   ATP synthase subunit C family protein
Brugia malayi Bm1_47320   ATP synthase lipid-binding protein, mitochondrial precursor
Candida albicans CaalfMp05   ATPase subunit 9
Caenorhabditis elegans CELE_Y82E9BR.3   Protein Y82E9BR.3
Dictyostelium discoideum DidioMp16   ATPase subunit 9
Drosophila melanogaster Dmel_CG1746   CG1746 gene product from transcript CG1746-RA
Escherichia coli b3737   F0 sector of membrane-bound ATP synthase, subunit c
Echinococcus granulosus EgrG_001064800   mitochondrial ATP synthase subunit 9
Echinococcus multilocularis EmuJ_001064800   mitochondrial ATP synthase subunit 9
Homo sapiens ENSG00000159199   ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
Homo sapiens ENSG00000135390   ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
Homo sapiens 518   ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
Leishmania braziliensis LbrM.21.0820   ATPase subunit 9, putative
Leishmania braziliensis LbrM.26.0480   ATPase subunit 9, putative
Leishmania donovani LdBPK_210820.1   ATPase subunit 9, putative
Leishmania donovani LdBPK_260450.1   ATPase subunit 9, putative
Leishmania donovani LdBPK_240640.1   ATPase subunit 9, putative
Leishmania infantum LinJ.21.0820   ATPase subunit 9, putative
Leishmania infantum LinJ.24.0640   ATPase subunit 9, putative
Leishmania major LmjF.24.0630   ATPase subunit 9, putative
Leishmania major LmjF.21.0740   ATPase subunit 9, putative
Leishmania major LmjF.26.0460   ATPase subunit 9, putative
Leishmania mexicana LmxM.21.0740   ATPase subunit 9, putative
Leishmania mexicana LmxM.26.0460   ATPase subunit 9, putative
Mycobacterium leprae ML1140   PROBABLE ATP SYNTHASE C CHAIN ATPE (LIPID-BINDING PROTEIN) (DICYCLOHEXYLCARBODIIMIDE-BINDING PROTEIN)
Mus musculus ENSMUSG00000018770   ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)
Mus musculus ENSMUSG00000062683   ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9)
Mus musculus 11951   ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9)
Mycobacterium tuberculosis Rv1305   Probable ATP synthase C chain AtpE (lipid-binding protein) (dicyclohexylcarbodiimide-binding protein)
Mycobacterium ulcerans MUL_3959   F0F1 ATP synthase subunit C
Neospora caninum NCLIV_065850   ATP synthase lipid-binding protein, putative
Oryza sativa 6450130   ATP synthase F0 subunit 9
Oryza sativa 3131392   ATPase III subunit
Plasmodium berghei PBANKA_0803500   ATP synthase subunit C, putative
Plasmodium falciparum PF3D7_0705900   ATP synthase subunit C, putative
Plasmodium knowlesi PKNH_0104400   ATPase subunit 9, putative
Plasmodium vivax PVX_087835   ATP synthase lipid-binding protein, mitochondrial precursor, putative
Plasmodium yoelii PY03813   ATPase subunit 9, putative
Saccharomyces cerevisiae Q0130   F0 ATP synthase subunit C
Schistosoma japonicum Sjp_0205580   ko:K02128 F-type H+-transporting ATPase subunit c, putative
Schistosoma mansoni Smp_000880.1   ATP synthase lipid-binding protein-like protein
Schistosoma mansoni Smp_000880.2   ATP synthase lipid-binding protein-like protein
Schmidtea mediterranea mk4.000902.01   ATP synthase lipid-binding protein, mitochondrial
Schmidtea mediterranea mk4.009442.00   ATP synthase lipid-binding protein, mitochondrial
Trypanosoma brucei gambiense Tbg972.7.1470   ATPase subunit 9, putative
Trypanosoma brucei gambiense Tbg972.10.1860   ATPase subunit 9, putative
Trypanosoma brucei gambiense Tbg972.11.5960   ATPase subunit 9, putative
Trypanosoma brucei Tb927.11.5280   Mitochondrial ATP synthase subunit c-1
Trypanosoma brucei Tb927.10.1570   Mitochondrial ATP synthase subunit c-2
Trypanosoma brucei Tb927.8.595   hypothetical protein
Trypanosoma brucei Tb927.7.1470   Mitochondrial ATP synthase subunit c-3
Trypanosoma congolense TcIL3000_7_970   ATPase subunit 9, putative
Trypanosoma cruzi TcCLB.507517.60   ATPase subunit 9, putative
Trypanosoma cruzi TcCLB.503579.70   ATPase subunit 9, putative
Trypanosoma cruzi TcCLB.506977.70   ATPase subunit 9, putative
Trypanosoma cruzi TcCLB.504125.40   ATPase subunit 9, putative
Trypanosoma cruzi TcCLB.504131.180   ATPase subunit 9, putative
Toxoplasma gondii TGME49_249720   ATP synthase F0 subunit 9, putative
Theileria parva TP02_0804   ATP synthase F0, subunit C, putative
Wolbachia endosymbiont of Brugia malayi Wbm0459   ATP synthase F0F1 subunit C

Essentiality

Smp_000880.1 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu1327 Mycobacterium tuberculosis essential nmpdr
Tb927.10.1570 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.1570 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.1570 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.1570 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.7.1470 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.1470 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.1470 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.1470 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.02.2950 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.2950 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.2950 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.2950 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b3737 Escherichia coli non-essential goodall
CELE_Y82E9BR.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y82E9BR.3 Caenorhabditis elegans larval arrest wormbase
TGME49_249720 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mycobacterium smegmatis Putative uncharacterized protein atpE Compounds References
Mycobacterium leprae PROBABLE ATP SYNTHASE C CHAIN ATPE (LIPID-BINDING PROTEIN) (DICYCLOHEXYLCARBODIIMIDE-BINDING PROTEIN) Compounds References
Mycobacterium tuberculosis Probable ATP synthase C chain AtpE (lipid-binding protein) (dicyclohexylcarbodiimide-binding protein) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0233 0.4484 0.8071
0.0106 0.2603 0.2591
0.013 0.4153 0.5964
0.0064 1 1
0.0213 0.4469 0.7817
0.0216 0.4488 0.8053
0.025 0.4482 0.8091
0.0224 0.4466 0.7395
0.0225 0.4438 0.8075
0.0233 0.2743 0.7394
0.0129 0.4047 0.5858
0.013 0.4153 0.5964
0.0237 0.4484 0.8075
0.0108 0.2825 0.2825

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_000880.1 (Schistosoma mansoni), ATP synthase lipid-binding protein-like protein
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