Detailed view for LmjF.06.0880

Basic information

TDR Targets ID: 29470
Leishmania major, acyl-coenzyme a dehydrogenase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.7811 | Length (AA): 416 | MW (Da): 45296 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00441   Acyl-CoA dehydrogenase, C-terminal domain
PF02770   Acyl-CoA dehydrogenase, middle domain
PF02771   Acyl-CoA dehydrogenase, N-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016627   oxidoreductase activity, acting on the CH-CH group of donors  
GO:0003995   acyl-CoA dehydrogenase activity  
GO:0050660   FAD binding  
GO:0016491   oxidoreductase activity  
GO:0009055   electron carrier activity  
GO:0008152   metabolic process  
GO:0055114   oxidation reduction  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
27 412 2fon (A) 16 439 21.00 0 1 1.03 0.05
40 413 1egd (A) 11 392 61.00 0 1 1.72 -1.66
40 414 3mdd (A) 11 393 62.00 0 1 1.66904 -0.97

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_129653)

Species Accession Gene Product
Brugia malayi Bm1_33775   2-methyl branched-chain enoyl CoA reductase isoform I, putative
Caenorhabditis elegans CELE_K05F1.3   Protein ACDH-8
Caenorhabditis elegans CELE_T25G12.5   Protein ACDH-7
Drosophila melanogaster Dmel_CG12262   CG12262 gene product from transcript CG12262-RA
Homo sapiens ENSG00000117054   acyl-CoA dehydrogenase, C-4 to C-12 straight chain
Leishmania braziliensis LbrM.06.0850   acyl-coenzyme a dehydrogenase, putative
Leishmania braziliensis LbrM.06.0870   acyl-coenzyme a dehydrogenase, putative
Leishmania donovani LdBPK_060910.1   acyl-coenzyme a dehydrogenase, putative
Leishmania infantum LinJ.06.0910   acyl-coenzyme a dehydrogenase, putative
Leishmania major LmjF.06.0880   acyl-coenzyme a dehydrogenase, putative
Leishmania mexicana LmxM.06.0880   acyl-coenzyme a dehydrogenase, putative
Loa Loa (eye worm) LOAG_07037   acyl CoA DeHydrogenase family member
Loa Loa (eye worm) LOAG_06636   hypothetical protein
Mus musculus ENSMUSG00000062908   acyl-Coenzyme A dehydrogenase, medium chain
Mycobacterium tuberculosis Rv3274c   Probable acyl-CoA dehydrogenase FadE25
Mycobacterium ulcerans MUL_4948   acyl-CoA dehydrogenase FadE25_2
Mycobacterium ulcerans MUL_2626   acyl-CoA dehydrogenase FadE25
Trypanosoma cruzi TcCLB.509153.120   acyl-CoA dehydrogenase, putative
Trypanosoma cruzi TcCLB.510303.290   acyl-CoA dehydrogenase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.2

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.06.0880 (Leishmania major), acyl-coenzyme a dehydrogenase, putative
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