Detailed view for Smp_156400

Basic information

TDR Targets ID: 295204
Schistosoma mansoni, cytochrome P450

Source Database / ID:  GeneDB

pI: 9.4401 | Length (AA): 414 | MW (Da): 47502 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00067   Cytochrome P450

Gene Ontology

Mouse over links to read term descriptions.
GO:0016705   oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen  
GO:0020037   heme binding  
GO:0009055   electron carrier activity  
GO:0005506   iron ion binding  
GO:0004497   monooxygenase activity  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
31 401 6fyj (A) 5 412 15.00 0 1 0.779535 0.18
34 104 1po5 (A) 29 100 25.00 0 0.89 0.451898 0.06
37 78 6bdh (A) 39 80 24.00 0.014 0.65 0.384649 -0.42
295 365 3czh (A) 392 469 34.00 0.074 0.66 0.340498 1.4

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_186258)

Species Accession Gene Product
Echinococcus granulosus EgrG_000814350   cytochrome P450 2K1
Echinococcus multilocularis EmuJ_000814350  
Schistosoma japonicum Sjp_0213500   IPR001128,Cytochrome P450,domain-containing
Schistosoma japonicum Sjp_0213510   ko:K00517 CYP81D8 (cytochrome P450, family 81, subfamily D, polypeptide 8); oxygen binding [EC:1.14.-.-], putative
Schistosoma mansoni Smp_156400   cytochrome P450

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0004 0.5 0.5
0.0062 0.2905 0.8143
0.0007 0.5 0.5
0.0004 0.5 0.5
0.0012 0.5 0.5
0.0069 0.5 0.5
0.0004 0.5 0.5
0.0012 0.5 0.5
0.0004 0.5 0.5
0.0034 0.337 0.337
0.0011 1 1
0.0004 0.5 0.5
0.0025 0.5 0.5
0.0003 0.5 0.5
0.0047 0.6689 0.5
0.0004 0.5 0.5
0.0092 0.467 1
0.0008 0.5 0.5
0.0055 0.5 0.5
0.0004 0.5 0.5
0.0042 0.3378 1
0.0012 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0029 0.36 0.36
0.0004 0.5 0.5
0.00213675 0.269186 0.355448
0.0011 0.5 0.5
0.0042 1 1
0.0167 0.2978 0.3634
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0145 0.7126 0.7126
0.008 0.5 0.5
0.0004 0.5 0.5
0.0044 0.2627 0.2239
0.004 1 1
0.0068 0.4312 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0028 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0038 0.5102 0
0.0004 0.5 0.5
0.0019 0.5 0.5
0.0008 0.5 0.5
0.0018 0.2876 0.7901
0.0032 0.5 0.5
0.0246 0.2667 1
0.0071 0.3514 0.3514
0.0353 0.4928 0.4895
0.0004 0.5 0.5
0.0007 0.5 0.5
0.034 0.2765 1
0.0084 0.3462 0.3388
0.025 0.2789 1
0.0012 0.5 0.5
0.0341 0.2689 1
0.0004 0.5 0.5
0.0316 0.2652 0.2784
0.0065 0.3393 0
0.0235 0.3192 0.4038
0.0047 0.6638 0.5
0.0084 1 0.5
0.0004 0.5 0.5
0.015 0.2827 0.5883
0.0004 0.5 0.5
0.007 1 1
0.005 0.5 0.5
0.0368 0.2796 1
0.005 0.3622 0.3466
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0023 0.9674 0.9674
0.0121 1 1
0.0063 0.2543 0.2484
0.0094 0.5 0.5
0.0023 1 1
0.00213675 0.269186 0.355448
0.0083 0.5 0.5
0.0053 1 1
0.0111 0.3549 1
0.0004 0.5 0.5
0.005 0.2698 0.3408
0.0046 0.2608 0.2211
0.0004 0.5 0.5
0.0074 1 1
0.0443 0.3118 0.5879
0.0087 1 1
0.0049 0.293 0.9307
0.0004 0.5 0.5
0.0012 0.5 0.5
0.0004 0.5 0.5
0.004 1 1
0.0004 0.5 0.5
0.0071 0.5 0.5
0.0118 0.3485 0.6496
0.0018 0.5004 0.4883
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0051 0.5 0.5
0.0569 0.2624 0.4594
0.0091 0.2951 1
0.00213675 0.269186 0.355448
0.0008 1 1
0.0331 0.3985 0.9357
0.0019 0.271 0.2899
0.0004 0.5 0.5
0.0119 0.4458 1
0.0047 0.6638 0.5
0.0004 0.5 0.5
0.0008 0.5 0.5
0.0018 0.5 0.5
0.0004 0.5 0.5
0.000376403 0.5 0.5
0.0007 0.5 0.5
0.0162 0.2769 0.2769
0.005 1 1
0.0004 0.5 0.5
0.0026 0.5 0.5
0.0166 0.5366 1
0.0004 0.5 0.5
0.0008 0.3317 0.3317
0.0054 0.5 0.5
0.007 0.3303 0.4926
0.0038 0.525 1
0.0324 0.2701 1
0.0059 0.5 0.5
0.0019 0.5 0.5
0.0022 0.5 0.5
0.0042 0.5 0.5
0.0036 0.5 0.5
0.0071 0.2928 1
0.0011 0.5 0.5
0.004 1 1
0.0036 1 1
0.0015 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0067 0.5 0.5
0.0056 0.6399 0.8158
0.0106 0.2751 1
0.0004 0.5 0.5
0.0099 0.7062 1
0.0052 0.2829 0.543
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0146 0.6654 0.6654
0.0057 0.2766 0.2752
0.0004 0.5 0.5
0.0083 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0048 0.6634 0.5
0.0063 0.5 0.5
0.0011 0.5 0.5
0.0078 0.3003 0.3003
0.0004 0.5 0.5
0.0291 0.2657 1
0.0047 0.5 0.5
0.015 0.3435 0.3996
0.0569 0.2624 0.4594
0.008 0.2556 1
0.0336 0.2847 1
0.015 0.2827 0.5883
0.0049 0.6682 0.5
0.0103 0.4147 0.4168
0.0073 0.5 0.5
0.0137 0.271 1
0.0046 0.5 0.5
0.0067 0.5 0.5
0.0019 0.5 0.5
0.0004 0.5 0.5
0.007 0.5 0.5
0.0018 1 1
0.0114 1 1
0.0102 0.3061 0.3397
0.0011 0.5 0.5
0.0021 0.5 0.5
0.0027 0.5 0.5
0.0078 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0029 1 1
0.0063 0.4653 0.4643
0.0007 0.5 0.5
0.0066 0.5 0.5
0.0004 0.5 0.5
0.0038 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0028 0.2972 1
0.0217 0.8044 1
0.0004 0.5 0.5
0.0066 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0055 0.2887 0.3183
0.004 1 1
0.0071 0.9628 1
0.0022 0.3789 0.3789
0.0127 0.5337 0.5337
0.0059 0.6064 0.6064
0.0072 1 1
0.0174 0.2937 0.384
0.0033 0.5 0.5
0.0093 0.3481 0.3426
0.0004 0.5 0.5
0.0008 0.5 0.5
0.0026 0.5 0.5
0.0146 0.6069 0.6069
0.0007 0.5 0.5
0.0235 0.2812 0.2815
0.0056 0.3577 1
0.0011 0.5 0.5
0.0008 0.5 0.5
0.0094 0.2887 0.7272
0.0075 0.2816 0.7314
0.0093 0.5 0.5
0.0268 0.2982 0.6976
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0038 0.5 0.5
0.0289 0.2916 0.389
0.0157 0.3541 0.4321
0.0012 0.5 0.5
0.006 0.2795 1
0.0011 0.5 0.5
0.0099 0.7122 1
0.0027 1 1
0.0193 0.311 0.3828
0.0004 0.5 0.5
0.0067 0.5 0.5
0.0004 0.5 0.5
0.0079 0.2909 0.5653
0.0065 1 1
0.0016 0.5 0.5
0.0262 0.3083 0.7243
0.0059 0.5 0.5
0.0073 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0071 0.5 0.5
0.0083 0.6735 1
0.0069 0.2847 0.4473
0.0035 0.4422 0.4361
0.0004 0.5 0.5
0.0065 0.5 0.5
0.0092 1 1
0.0052 0.3825 0.3825
0.0075 0.3265 0.3285
0.0007 0.5 0.5
0.0032 1 1
0.0048 1 1
0.0018 0.5004 0.4883
0.0004 0.5 0.5
0.0368 0.2796 1
0.003 0.3514 1
0.000376403 0.5 0.5
0.0011 1 1
0.0044 0.4237 1
0.0011 0.5 0.5
0.0008 0.5 0.5
0.0019 0.2756 0.2756
0.0004 0.5 0.5
0.0067 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0029 0.5 0.5
0.0124 0.2696 0.2696
0.0015 0.5 0.5
0.0022 0.5 0.5
0.0036 0.5 0.5
0.0059 0.6064 0.6064
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0203 0.2689 0.6257
0.0012 0.5 0.5
0.0007 0.5 0.5
0.0284 0.2924 0.3384
0.0004 0.5 0.5
0.0216 0.2583 1
0.0004 0.5 0.5
0.0023 1 1
0.0048 0.6597 0.5
0.0007 0.5 0.5
0.0104 0.5 0.5
0.0004 0.5 0.5
0.0045 0.5 0.5
0.0004 0.5 0.5
0.0016 1 1
0.0018 0.5 0.5
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0015 0.5 0.5
0.003 0.3271 0.3271
0.0004 0.5 0.5
0.0228 0.2829 1
0.0028 0.5 0.5
0.0018 0.5 0.5
0.0052 0.3769 0.3617
0.0023 0.5 0.5
0.0045 0.5 0.5
0.0284 0.2726 1
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0114 1 1
0.0286 1 1
0.0004 0.5 0.5
0.0077 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0011 1 1
0.0019 0.271 0.2899
0.0197 0.6846 0.9033
0.0108 0.2733 1
0.0018 0.3602 0.3602
0.0062 0.5 0.5
0.0012 1 1
0.0103 0.6953 1
0.0133 0.256 0.256
0.0008 0.5 0.5
0.0033 0.5 0.5
0.0388 0.2772 1
0.0007 0.5 0.5
0.0022 0.3489 0.3489
0.0046 0.6591 0.6342
0.0015 0.5 0.5
0.0004 0.5 0.5
0.00777519 0.280873 1
0.0015 0.5 0.5
0.0018 0.5 0.5
0.0004 0.5 0.5
0.0068 0.5 0.5
0.0004 0.5 0.5
0.0033 0.5 0.5
0.0217 0.2742 1
0.0069 1 1
0.0326 0.2819 1
0.0004 1 1
0.0073 1 1
0.0082 0.5 0.5
0.0164 0.3784 1
0.0004 0.5 0.5
0.0032 1 1
0.0037 0.2694 0.2389
0.008 1 1
0.0081 0.5 0.5
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0059 0.6064 0.6064
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.026 0.251 1
0.0065 1 1
0.0103 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0008 0.3317 0.3317
0.0033 0.2605 0.4761
0.0166 0.2888 0.3221
0.0173 0.3457 0.3903
0.0388 0.2772 1
0.0323 0.3673 0.8616
0.0003 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0014 0.5 0.5
0.007 1 1
0.0081 0.5 0.5
0.000396385 0.5 0.5
0.0032 0.5 0.5
0.0004 0.5 0.5
0.00213675 0.269186 0.355448
0.0004 0.5 0.5
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0323 0.2823 0.3349
0.033 0.3723 0.4192
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0051 0.4977 1
0.033 0.3723 0.4192
0.0063 0.5 0.5
0.0004 0.5 0.5
0.007 0.5713 0
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0021 0.4036 0.3713
0.000218985 0.5 0.5
0.0023 0.5 0.5
0.036 0.2841 0.4174
0.0316 0.2652 0.2784
0.0019 0.5 0.5
0.00139338 1 1
0.0076 1 1
0.0046 0.5 0.5
0.0189 0.5524 1
0.0004 0.5 0.5
0.0002 0.5 0.5
0.004 1 1
0.0004 0.5 0.5
0.0082 0.5 0.5
0.0331 0.3985 0.9357
0.0046 0.6591 0.6342
0.0249 0.3082 1
0.0012 0.5 0.5
0.0044 0.6112 0.5
0.0119 0.5 0.5
0.0026 0.5 0.5
0.0036 0.4353 0.5
0.002 1 1
0.0003 0.5 0.5
0.033 0.3723 0.4192
0.0122 0.4249 0.5607
0.0032 0.5 0.5
0.0051 0.3758 0.3758
0.0176 0.3425 0.3279
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0086 0.5 0.5
0.002 0.5 0.5
0.0018 0.2637 0.2637
0.0119 0.4458 1
0.0004 0.5 0.5
0.008 0.2582 1
0.0133 0.2787 0.2766
0.0033 0.3348 0.5
0.0068 1 1
0.0004 0.5 0.5
0.01 0.5 0.5
0.0004 0.5 0.5
0.0045 0.5 0.5
0.0037 0.4283 0.6306
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0184 0.3352 0.6444
0.0004 0.5 0.5
0.0075 1 1
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0346 0.2559 0.4088
0.0004 0.5 0.5
0.00505219 0.5 0.5
0.0004 1 1
0.0084 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0185 0.2528 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0025 0.5 0.5
0.0267 0.27 0.9859
0.0082 0.5 0.5
0.0353 0.4928 0.4895
0.0007 1 1
0.0184 0.3508 0.4171
0.0156 0.4244 0.7189
0.0202 0.2702 0.3684
0.0016 1 1
0.0004 0.5 0.5
0.0018 0.5 0.5
0.0173 0.3858 0.4396
0.0027 1 1
0.0004 0.5 0.5
0.0072 1 1
0.00184047 0.269186 0.355448
0.0004 0.5 0.5
0.0063 0.3886 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.004 0.5565 0.5
0.0004 1 1
0.0004 0.5 0.5
0.0058 0.5 0.5
0.000218985 0.5 0.5
0.0007 1 1
0.0004 0.5 0.5
0.0361 0.2704 1
0.0004 0.5 0.5
0.0059 0.6064 0.6064
0.0054 1 1
0.0004 0.5 0.5
0.00109509 1 1
0.0087 1 1
0.0057 0.2766 0.2752
0.00451124 0.405669 1
0.0051 0.5 0.5
0.026 0.251 1
0.0284 0.2924 0.3384

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Smp_156400 (Schistosoma mansoni), cytochrome P450
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