Detailed view for Smp_149170

Basic information

TDR Targets ID: 295238
Schistosoma mansoni, dro/myosuppressin receptor
Source Database / ID:  GeneDB

pI: 8.8687 | Length (AA): 441 | MW (Da): 49944 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF10324   Serpentine type 7TM GPCR chemoreceptor Srw

Gene Ontology

Mouse over links to read term descriptions.
GO:0008528   peptide receptor activity, G-protein coupled  
GO:0016021   integral to membrane  
GO:0004930   G-protein coupled receptor activity  
GO:0007186   G-protein coupled receptor protein signaling pathway  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
48 167 6fuf (A) 36 144 33.00 0.0016 0.33 0.229009 1.78
52 373 5zkc (A) 29 451 25.00 0.22 0.99 0.789059 0.22

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_194208)

Species Accession Gene Product
Schistosoma mansoni Smp_149170   dro/myosuppressin receptor
Schmidtea mediterranea mk4.031060.00   Putative dro/myosuppressin receptor

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Gorilla gorilla Serotonin 1b (5-HT1b) receptor 390 aa 23.7% 337 aa Compounds References
Rattus norvegicus Thyrotropin-releasing hormone receptor 412 aa 23.2% 332 aa Compounds References
Cricetulus griseus 5-hydroxytryptamine receptor 1B 386 aa 25.0% 336 aa Compounds References
Rattus norvegicus Serotonin 1b (5-HT1b) receptor 386 aa 24.0% 334 aa Compounds References
Chlorocebus aethiops Dopamine D3 receptor 400 aa 20.1% 393 aa Compounds References
Rattus norvegicus Serotonin 1f (5-HT1f) receptor 366 aa 20.1% 333 aa Compounds References
Rattus norvegicus Orexin receptor 1 416 aa 21.9% 334 aa Compounds References
Sus scrofa Serotonin 1d (5-HT1d) receptor 291 aa 23.9% 247 aa Compounds References
Rattus norvegicus Serotonin (5-HT) receptor 386 aa 24.0% 334 aa Compounds References
Rattus norvegicus Serotonin 1 (5-HT1) receptor 366 aa 20.1% 333 aa Compounds References
Rattus norvegicus Galanin receptor 2 372 aa 19.5% 344 aa Compounds References
Cavia porcellus Serotonin 1d (5-HT1d) receptor 376 aa 25.1% 334 aa Compounds References
Rattus norvegicus Serotonin 1B/1D receptor 374 aa 24.5% 330 aa Compounds References
Macaca mulatta Beta-3 adrenergic receptor 418 aa 19.8% 339 aa Compounds References
Rattus norvegicus Serotonin 1d (5-HT1d) receptor 374 aa 24.5% 330 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_149170 (Schistosoma mansoni), dro/myosuppressin receptor
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