Detailed view for Smp_074200.2

Basic information

TDR Targets ID: 295521
Schistosoma mansoni, ubiquitin-specific peptidase 45 (C19 family)
Source Database / ID:  GeneDB

pI: 7.2908 | Length (AA): 749 | MW (Da): 84571 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00443   Ubiquitin carboxyl-terminal hydrolase

Gene Ontology

Mouse over links to read term descriptions.
GO:0036459   GO:thiol-dependent ubiquitinyl hydrolase activity  

GO:0016579   protein deubiquitination  
GO:0004221   ubiquitin thiolesterase activity  
GO:0006511   ubiquitin-dependent protein catabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
36 159 3ihp (A) 327 449 32.00 0.018 0.44 0.303854 -0.41
544 617 5cht (A) 245 322 46.00 0.0081 0.11 0.181098 1.72
687 749 6gh9 (B) 838 905 29.00 0.005 0.1 0.378012 -0.34
697 748 5ohk (A) 443 502 37.00 0.098 0.25 0.394726 0.53

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131871)

Species Accession Gene Product
Arabidopsis thaliana AT1G04860   ubiquitin-specific protease 2
Arabidopsis thaliana AT2G32780   ubiquitin carboxyl-terminal hydrolase 1
Brugia malayi Bm1_33170   Ubiquitin carboxyl-terminal hydrolase family protein
Dictyostelium discoideum DDB_G0274207   peptidase C19 family protein
Echinococcus granulosus EgrG_000929000   ubiquitin carboxyl terminal hydrolase 16
Echinococcus multilocularis EmuJ_000929000   ubiquitin carboxyl terminal hydrolase 16
Homo sapiens ENSG00000156256   ubiquitin specific peptidase 16
Loa Loa (eye worm) LOAG_02543   ubiquitin carboxyl-terminal hydrolase
Mus musculus ENSMUSG00000025616   ubiquitin specific peptidase 16
Oryza sativa 4347503   Os09g0505100
Schistosoma japonicum Sjp_0061650   ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative
Schistosoma mansoni Smp_074200.1   ubiquitin-specific peptidase 16 (C19 family)
Schistosoma mansoni Smp_074200.2   ubiquitin-specific peptidase 45 (C19 family)
Schmidtea mediterranea mk4.003152.00   Ubiquitin carboxyl-terminal hydrolase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0004 0.5 0.5
0.0003 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_074200.2 (Schistosoma mansoni), ubiquitin-specific peptidase 45 (C19 family)
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