Detailed view for Smp_000740.1

Basic information

TDR Targets ID: 295527
Schistosoma mansoni, 26s proteasome non-ATPase regulatory subunit 4
Source Database / ID:  GeneDB

pI: 4.4368 | Length (AA): 410 | MW (Da): 44627 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02809   Ubiquitin interaction motif
PF13519   von Willebrand factor type A domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008540   proteasome regulatory particle, base subcomplex  
GO:0006511   ubiquitin-dependent protein catabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 178 5ln1 (A) 1 191 46.00 0 1 1.04725 -1.15
2 188 2x5n (A) 2 193 37.00 0.14 1 1.0147 -1.09
4 180 2x5n (A) 4 190 45.00 0 1 1.03481 -1.25

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127854)

Species Accession Gene Product
Arabidopsis thaliana AT4G38630   26S proteasome non-ATPase regulatory subunit 4
Babesia bovis BBOV_II002240   hypothetical protein
Brugia malayi Bm1_28050   26S proteasome subunit-like protein
Brugia malayi Bm1_56535   Ubiquitin interaction motif family protein
Candida albicans CaO19.4102   similar to S. cerevisiae RPN10 (YHR200W) subunit of the 19S regulatory particle of the 26S proteasome
Candida albicans CaO19.11583   similar to S. cerevisiae RPN10 (YHR200W) subunit of the 19S regulatory particle of the 26S proteasome
Caenorhabditis elegans CELE_B0205.3   Protein RPN-10
Cryptosporidium hominis Chro.40069   26S proteasome regulatory subunit S5A
Cryptosporidium parvum cgd4_530   26S proteasome regulatory subunit 5a with a vWA domain and two ubiquitin interacting motifs (UIM)
Dictyostelium discoideum DDB_G0275775   26S proteasome non-ATPase regulatory subunit 4
Drosophila melanogaster Dmel_CG7619   Regulatory particle non-ATPase 10
Echinococcus granulosus EgrG_000725300   26S proteasome non ATPase regulatory subunit 4
Entamoeba histolytica EHI_005870   proteasome regulatory subunit, putative
Echinococcus multilocularis EmuJ_000725300   26S proteasome non ATPase regulatory subunit 4
Giardia lamblia GL50803_15604   Hypothetical protein
Homo sapiens ENSG00000159352   proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
Leishmania braziliensis LbrM.07.1200   proteasome regulatory non-ATP-ase subunit, putative
Leishmania donovani LdBPK_071300.1   proteasome regulatory non-ATP-ase subunit, putative
Leishmania infantum LinJ.07.1300   proteasome regulatory non-ATP-ase subunit, putative
Leishmania major LmjF.07.1120   proteasome regulatory non-ATP-ase subunit, putative
Leishmania mexicana LmxM.07.1120   proteasome regulatory non-ATP-ase subunit, putative
Mus musculus ENSMUSG00000005625   proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
Neospora caninum NCLIV_048550   26S proteasome non-ATPase regulatory subunit 4, putative
Oryza sativa 4332222   Os03g0243300
Plasmodium berghei PBANKA_1222900   26S proteasome regulatory subunit RPN10, putative
Plasmodium falciparum PF3D7_0807800   26S proteasome regulatory subunit RPN10, putative
Plasmodium knowlesi PKNH_0110900   26S proteasome regulatory subunit RPN10, putative
Plasmodium vivax PVX_088150   26S proteasome regulatory subunit RPN10, putative
Plasmodium yoelii PY04193   26s proteasome regulatory subunit s5a (multiubiquitin chain binding protein). [mouse-ear cress-related
Saccharomyces cerevisiae YHR200W   proteasome regulatory particle base subunit RPN10
Schistosoma japonicum Sjp_0102740   26S proteasome non-ATPase regulatory subunit 4, putative
Schistosoma japonicum Sjp_0305440   26S proteasome non-ATPase regulatory subunit 4, putative
Schistosoma japonicum Sjp_0068900   26S proteasome non-ATPase regulatory subunit 4, putative
Schistosoma japonicum Sjp_0217580   ko:K00889 1-phosphatidylinositol-4-phosphate 5-kinase [EC2.7.1.68], putative
Schistosoma mansoni Smp_000740.2   multiubiquitin binding protein S5a
Schistosoma mansoni Smp_000740.1   26s proteasome non-ATPase regulatory subunit 4
Schmidtea mediterranea mk4.002826.00   26S proteasome non-ATPase regulatory subunit 4
Schmidtea mediterranea mk4.008006.01   26S proteasome non-ATPase regulatory subunit 4
Schmidtea mediterranea mk4.005186.02  
Schmidtea mediterranea mk4.017626.00  
Schmidtea mediterranea mk4.004698.00   26S proteasome non-ATPase regulatory subunit 4
Schmidtea mediterranea mk4.009257.00   26S proteasome non-ATPase regulatory subunit 4
Schmidtea mediterranea mk4.032336.00   26S proteasome non-ATPase regulatory subunit 4
Schmidtea mediterranea mk4.013526.00   26S proteasome non-ATPase regulatory subunit 4
Schmidtea mediterranea mk4.005212.02   26S proteasome non-ATPase regulatory subunit 4
Schmidtea mediterranea mk4.005821.07  
Schmidtea mediterranea mk4.008762.00   26S proteasome non-ATPase regulatory subunit 4
Schmidtea mediterranea mk4.009690.01   26S proteasome non-ATPase regulatory subunit 4
Schmidtea mediterranea mk4.004896.00   26S proteasome non-ATPase regulatory subunit 4
Schmidtea mediterranea mk4.021294.00   26S proteasome non-ATPase regulatory subunit 4
Trypanosoma brucei gambiense Tbg972.8.150   proteasome regulatory non-ATP-ase subunit 10, putative
Trypanosoma brucei Tb927.8.570   proteasome regulatory non-ATP-ase subunit 10
Trypanosoma congolense TcIL3000_0_23920   proteasome regulatory non-ATP-ase subunit 10
Trypanosoma congolense TcIL3000_8_40   proteasome regulatory non-ATP-ase subunit 10, putative
Trypanosoma cruzi TcCLB.509611.160   proteasome regulatory non-ATPase subunit, putative
Trypanosoma cruzi TcCLB.510855.40   proteasome regulatory non-ATPase subunit, putative
Toxoplasma gondii TGME49_223960   ubiquitin interaction motif family protein
Theileria parva TP04_0368   hypothetical protein, conserved
Trichomonas vaginalis TVAG_108340   26S proteasome non-ATPase regulatory subunit, putative
Trichomonas vaginalis TVAG_328160   26S proteasome non-ATPase regulatory subunit, putative
Trichomonas vaginalis TVAG_173600   26S proteasome non-ATPase regulatory subunit, putative
Trichomonas vaginalis TVAG_486140   26S proteasome non-ATPase regulatory subunit, putative

Essentiality

Smp_000740.1 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.570 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.8.570 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.570 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.8.570 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_223960 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Smp_000740.1 (Schistosoma mansoni), 26s proteasome non-ATPase regulatory subunit 4
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