Detailed view for Smp_175610.2

Basic information

TDR Targets ID: 295664
Schistosoma mansoni, dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase
Source Database / ID:  GeneDB

pI: 6.2586 | Length (AA): 576 | MW (Da): 63825 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00085   Thioredoxin
PF00364   Biotin-requiring enzyme
PF02817   e3 binding domain
PF06201   PITH domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016746   transferase activity, transferring acyl groups  
GO:0005515   protein binding  
GO:0008415   acyltransferase activity  
GO:0008152   metabolic process  
GO:0045454   cell redox homeostasis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
33 155 3mxu (A) 0 113 19.00 0 0.25 0.261442 0.21
63 168 2dne (A) 2 107 45.00 0 1 0.774228 -0.53
64 157 1y8o (B) 128 226 61.00 0 1 0.968394 -1.08
208 240 2eq8 (C) 131 163 48.00 0.11 0.99 0.681992 -0.53
271 477 5d8i (A) 38 253 20.00 0 1 0.516275 -0.03
275 387 2vlu (A) 12 121 37.00 0 1 0.868081 -2.55
299 383 1gh2 (A) 21 105 33.00 0.00000015 1 0.805269 -2.35

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129293)

Species Accession Gene Product
Arabidopsis thaliana AT3G04780   hypothetical protein
Brugia malayi Bm1_05440   Thioredoxin family protein
Candida albicans CaO19.3319   thioredoxin-like protein similar to S. pombe SPBC577.08c
Candida albicans CaO19.10829   thioredoxin-like protein similar to S. pombe SPBC577.08c
Caenorhabditis elegans CELE_Y54E10A.3   Protein Y54E10A.3
Cryptosporidium hominis Chro.80403   thioredoxin-like, 32kDa; thioredoxin-related 32 kDa protein; thioredoxin-like, 32kD
Drosophila melanogaster Dmel_CG5495   Thioredoxin-like
Echinococcus granulosus EgrG_000317800   thioredoxin protein 1
Echinococcus multilocularis EmuJ_000317800   thioredoxin protein 1
Homo sapiens ENSG00000091164   thioredoxin-like 1
Loa Loa (eye worm) LOAG_10745   thioredoxin family protein
Mus musculus ENSMUSG00000024583   thioredoxin-like 1
Neospora caninum NCLIV_061750   hypothetical protein, conserved
Oryza sativa 4334415   Os03g0795500
Schistosoma japonicum Sjp_0216470   Thioredoxin-like protein 1, putative
Schistosoma mansoni Smp_175610.2   dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase
Schistosoma mansoni Smp_175610.1   dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase
Schmidtea mediterranea mk4.006316.00   Thioredoxin-like protein 1
Schmidtea mediterranea mk4.011068.01  
Toxoplasma gondii TGME49_218530   proteasome-interacting thioredoxin domain-containing protein
Toxoplasma gondii TGME49_247025   hypothetical protein
Theileria parva TP01_0475   hypothetical protein, conserved

Essentiality

Smp_175610.2 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_218530 Toxoplasma gondii Essentiality uncertain sidik
TGME49_247025 Toxoplasma gondii Essentiality uncertain sidik
TGME49_218530 Toxoplasma gondii Probably non-essential sidik
TGME49_247025 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_175610.2 (Schistosoma mansoni), dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase
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