Detailed view for Smp_124300

Basic information

TDR Targets ID: 295902
Schistosoma mansoni, Lamin B receptor (ERG24)

Source Database / ID:  GeneDB

pI: 10.5546 | Length (AA): 606 | MW (Da): 69120 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01222   Ergosterol biosynthesis ERG4/ERG24 family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 89 2fz1 (B) 98 180 12.00 0 0 0.254964 -0.19
163 290 3fh6 (F) 56 348 30.00 0.18 0.04 0.0493211 3.28
217 606 4quv (A) 60 427 29.00 0 0.96 0.806664 0.85

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128488)

Species Accession Gene Product
Arabidopsis thaliana AT3G52940   delta(14)-sterol reductase
Candida albicans CaO19.1598   similar to S. cerevisiae sterol C-14 reductase ERG24 (YNL280C) involved in ergosterol biosynthesis
Candida albicans CaO19.9166   similar to S. cerevisiae sterol C-14 reductase ERG24 (YNL280C) involved in ergosterol biosynthesis
Dictyostelium discoideum DDB_G0284407   Delta-sterol reductase
Dictyostelium discoideum DDB_G0267448   erg4/erg24 family protein
Drosophila melanogaster Dmel_CG17952   Lamin B receptor
Echinococcus granulosus EgrG_000379500   lamin b receptor
Echinococcus multilocularis EmuJ_000379500   lamin b receptor
Homo sapiens ENSG00000149809   transmembrane 7 superfamily member 2
Homo sapiens ENSG00000143815   lamin B receptor
Leishmania braziliensis LbrM.32.2550   C-14 sterol reductase, putative
Leishmania donovani LdBPK_322470.1   C-14 sterol reductase, putative
Leishmania infantum LinJ.32.2470   C-14 sterol reductase, putative
Leishmania major LmjF.32.2320   C-14 sterol reductase, putative
Leishmania mexicana LmxM.31.2320   C-14 sterol reductase, putative
Mus musculus ENSMUSG00000024799   transmembrane 7 superfamily member 2
Mus musculus ENSMUSG00000004880   lamin B receptor
Oryza sativa 9270556   Os01g0354200
Saccharomyces cerevisiae YNL280C   delta(14)-sterol reductase
Schistosoma japonicum Sjp_0205080   ko:K00222 delta14-sterol reductase [EC1.3.1.70], putative
Schistosoma japonicum Sjp_0317000   Lamin-B receptor, putative
Schistosoma mansoni Smp_124300   Lamin B receptor (ERG24)
Schmidtea mediterranea mk4.000442.04   Lamin-B receptor
Trypanosoma brucei gambiense Tbg972.11.17430   C-14 sterol reductase, putative
Trypanosoma brucei Tb927.11.15530   C-14 sterol reductase, putative
Trypanosoma congolense TcIL3000.11.15590   C-14 sterol reductase, putative
Trypanosoma congolense TcIL3000_0_39020   Ergosterol biosynthesis ERG4/ERG24 family, putative
Trypanosoma cruzi TcCLB.507969.60   C-14 sterol reductase, putative
Trypanosoma cruzi TcCLB.507129.30   C-14 sterol reductase, putative

Essentiality

Smp_124300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.7170 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.7170 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.7170 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.7170 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
YNL280C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Zea mays Delta(14)-sterol reductase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0241 0.2833 0.7052
0.011 0.5 0.5
0.0241 0.2833 0.7052
0.0097 0.574 0.9649

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_124300 (Schistosoma mansoni), Lamin B receptor (ERG24)
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