Detailed view for LmjF.30.3550

Basic information

TDR Targets ID: 29891
Leishmania major, cytochrome p450-like protein

Source Database / ID:  TriTrypDB  GeneDB

pI: 7.1741 | Length (AA): 508 | MW (Da): 58030 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00067   Cytochrome P450

Gene Ontology

Mouse over links to read term descriptions.
GO:0016705   oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen  
GO:0020037   heme binding  
GO:0009055   electron carrier activity  
GO:0005506   iron ion binding  
GO:0004497   monooxygenase activity  
GO:0055114   oxidation reduction  

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
35 500 1tqn (A) 28 498 19.00 0 1 1.24 -0.93
35 500 1tqn (A) 28 498 20.00 0 1 1.26 -1.2
43 499 1zo4 (A) 3 452 15.00 0 1 1.15 -1.26
3 500 4lxj (A) 18 526 19.00 0 1 1.15652 0.01
52 493 2ve3 (A) 20 437 26.00 0 1 1.20098 -0.58
58 496 4dvq (A) 52 500 18.00 0 1 1.09537 -0.64
269 463 4gqs (A) 237 452 27.00 0.00000013 1 0.624758 0.02
325 448 1s1f (A) 257 355 35.00 0.43 0.85 0.301995 0.5

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_131167)

Species Accession Gene Product
Arabidopsis thaliana AT2G28860   cytochrome P450 710A4
Arabidopsis thaliana AT2G34500   cytochrome P450 710A1
Arabidopsis thaliana AT2G34490   cytochrome P450 710A2
Arabidopsis thaliana AT2G28850   cytochrome P450 710A3
Candida albicans CaO19.12645   cytochrome P450 similar to S. cerevisiae ERG5 (YMR015C) C-22 sterol desaturase
Candida albicans CaO19.5178   cytochrome P450 similar to S. cerevisiae ERG5 (YMR015C) C-22 sterol desaturase
Candida albicans CaO19_5178   hypothetical protein
Dictyostelium discoideum DDB_G0269016   cytochrome P450 family protein
Drosophila melanogaster Dmel_CG4321   Cytochrome P450-4d8
Leishmania braziliensis LbrM.30.3580   cytochrome p450-like protein
Leishmania donovani LdBPK_303610.1   cytochrome p450-like protein
Leishmania infantum LinJ.30.3610   cytochrome p450-like protein
Leishmania major LmjF.30.3550   cytochrome p450-like protein
Leishmania mexicana LmxM.29.3550   cytochrome p450-like protein
Oryza sativa 4325563   Os01g0211200
Oryza sativa 4325564   Os01g0211600
Oryza sativa 9267882   Os01g0211000
Oryza sativa 9267503   Os03g0836100
Oryza sativa 4325562   Os01g0210900
Saccharomyces cerevisiae YMR015C   C-22 sterol desaturase
Trypanosoma cruzi TcCLB.506945.190   cytochrome p450-like protein, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5


Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Cytochrome P450 51 503 aa 21.2% 419 aa Compounds References
Sorghum bicolor Obtusifoliol 14-alpha demethylase 492 aa 21.7% 457 aa Compounds References

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0235 0.2812 0.4163
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0019 0.2756 0.5
0.0004 0.5 0.5
0.0084 1 0.5
0.0193 0.311 0
0.0072 1 1
0.0004 0.5 0.5
0.0038 0.525 0
0.004 1 1
0.0047 0.6638 0.6638
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0012 0.5 0.5
0.0023 0.5 0.5
0.0054 1 1
0.0118 0.3485 0
0.0004 0.5 0.5
0.0045 0.5 0.5
0.0007 0.5 0.5
0.0093 0.3481 0.7056
0.0004 0.5 0.5
0.0004 0.5 0.5
0.002 0.5 0.5
0.0032 0.5 0.5
0.0099 0.7122 0.5
0.0078 1 0.5
0.0012 0.5 0.5
0.0022 0.3789 0.5
0.0368 0.2796 0.2661
0.0076 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0078 0.3003 0.8731
0.0037 0.4283 0
0.0018 0.5 0.5
0.0011 0.5 0.5
0.0018 0.5 0.5
0.0004 0.5 0.5
0.008 1 0.5
0.0066 0.5 0.5
0.0093 0.5 0.5
0.0048 0.6597 0.6597
0.0331 0.3985 0.9211
0.0046 0.5 0.5
0.0015 0.5 0.5
0.0018 0.5004 0
0.0072 1 1
0.0011 0.5 0.5
0.0063 0.2543 0.6677
0.0027 0.5 0.5
0.0048 1 0.5
0.0067 0.5 0.5
0.0016 0.5 0.5
0.0004 1 0.5
0.0012 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.034 0.2765 0
0.0103 0.4147 0.4139
0.0004 0.5 0.5
0.0323 0.2823 0.3349
0.0119 0.5 0.5
0.0004 0.5 0.5
0.0167 0.2978 0
0.0063 0.3886 0
0.0004 0.5 0.5
0.0059 0.6064 0.5
0.0004 0.5 0.5
0.0011 0.5 0.5
0.003 0.3271 0.3271
0.0004 0.5 0.5
0.0166 0.5366 0
0.0127 0.5337 0
0.0166 0.2888 0
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0045 0.5 0.5
0.0268 0.2982 0.6893
0.0119 0.4458 0
0.0015 0.5 0.5
0.0004 0.5 0.5
0.0217 0.2742 0
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0008 0.5 0.5
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0121 1 1
0.0059 0.5 0.5
0.0022 0.5 0.5
0.0004 0.5 0.5
0.0046 0.2608 0.1859
0.00213675 0.269186 0
0.0059 0.6064 0.5
0.0028 0.2972 0.6218
0.0004 0.5 0.5
0.004 1 0.5
0.0569 0.2624 0.4601
0.0336 0.2847 0
0.0146 0.6654 0.5
0.0004 0.5 0.5
0.0071 0.5 0.5
0.0124 0.2696 0.2696
0.0004 0.5 0.5
0.0067 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0185 0.2528 0
0.0184 0.3508 0
0.0011 0.5 0.5
0.0011 0.5 0.5
0.000218985 0.5 0.5
0.0004 1 0.5
0.0286 1 1
0.0036 0.5 0.5
0.0203 0.2689 0.2582
0.0015 0.5 0.5
0.0029 0.5 0.5
0.0052 0.3825 1
0.0173 0.3457 0
0.0004 0.5 0.5
0.0022 0.5 0.5
0.0353 0.4928 1
0.0051 0.4977 0.5
0.0033 0.5 0.5
0.0004 0.5 0.5
0.0284 0.2924 0.419
0.0004 0.5 0.5
0.0011 1 0.5
0.0291 0.2657 0.2657
0.005 0.2698 0
0.0063 0.5 0.5
0.0028 0.5 0.5
0.0157 0.3541 0
0.005 0.3622 0.5
0.0004 0.5 0.5
0.0108 0.2733 0.2665
0.0004 0.5 0.5
0.025 0.2789 0
0.0246 0.2667 0.2667
0.0028 0.5 0.5
0.0038 0.5102 1
0.026 0.251 0.2723
0.033 0.3723 0.5186
0.0003 0.5 0.5
0.007 0.5713 0.5
0.0054 0.5 0.5
0.0012 0.5 0.5
0.005 1 1
0.008 0.2556 0.84
0.0087 1 1
0.007 0.5 0.5
0.0004 0.5 0.5
0.0045 0.5 0.5
0.0029 0.36 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0008 0.3317 0.2745
0.0073 0.5 0.5
0.0008 0.3317 0.2745
0.0011 1 0.5
0.0004 0.5 0.5
0.0036 0.5 0.5
0.0443 0.3118 0.6583
0.0216 0.2583 0
0.0012 0.5 0.5
0.0044 0.6112 0.6112
0.004 1 0.5
0.0071 0.3514 0.5
0.0022 0.3489 0.5
0.0007 1 0.5
0.0099 0.7062 0.5
0.0069 1 1
0.0003 0.5 0.5
0.0164 0.3784 0
0.0004 0.5 0.5
0.0249 0.3082 0.6599
0.0324 0.2701 0.2701
0.0012 0.5 0.5
0.033 0.3723 0.5186
0.0023 0.9674 0.5
0.0071 0.2928 0.4724
0.0007 1 0.5
0.0323 0.3673 0.849
0.0133 0.256 0.2574
0.0035 0.4422 0.5
0.0065 1 1
0.0069 0.2847 0.4473
0.00213675 0.269186 0
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0044 0.2627 0.057
0.000396385 0.5 0.5
0.0077 0.5 0.5
0.0004 1 0.5
0.0114 1 1
0.0174 0.2937 0
0.0083 1 0.5
0.0007 0.5 0.5
0.0004 0.5 0.5
0.00109509 1 0.5
0.0004 0.5 0.5
0.0018 0.5 0.5
0.0004 0.5 0.5
0.0091 0.2951 0.4172
0.0062 0.2905 0.4453
0.0004 0.5 0.5
0.0008 0.5 0.5
0.0026 0.5 0.5
0.0004 0.5 0.5
0.0094 0.5 0.5
0.0114 1 1
0.00451124 0.405669 0
0.0007 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0021 0.5 0.5
0.0015 0.5 0.5
0.0016 1 0.5
0.0004 0.5 0.5
0.0019 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.00213675 0.269186 0
0.0008 1 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0019 0.5 0.5
0.0084 0.5 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0025 0.5 0.5
0.0106 0.2751 0.2411
0.0004 0.5 0.5
0.00213675 0.269186 0
0.0004 0.5 0.5
0.000218985 0.5 0.5
0.0004 0.5 0.5
0.0104 0.5 0.5
0.0004 0.5 0.5
0.0046 0.6591 1
0.0026 0.5 0.5
0.0027 1 0.5
0.0008 0.5 0.5
0.0146 0.6069 0.5
0.0094 0.2887 0.445
0.0056 0.3577 1
0.0267 0.27 0
0.0092 1 1
0.0197 0.6846 0
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0083 0.6735 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.007 1 1
0.0217 0.8044 1
0.0012 0.5 0.5
0.0004 0.5 0.5
0.0173 0.3858 0
0.0032 1 0.5
0.0084 0.3462 0.8861
0.0004 0.5 0.5
0.0361 0.2704 0
0.0004 0.5 0.5
0.0092 0.467 0
0.004 0.5565 0.5565
0.0083 0.5 0.5
0.0032 0.5 0.5
0.0004 0.5 0.5
0.0057 0.2766 1
0.0284 0.2726 0.2726
0.0056 0.6399 1
0.0048 0.6634 0.6634
0.0004 0.5 0.5
0.0202 0.2702 0.5108
0.0033 0.2605 0.5
0.0011 0.5 0.5
0.0086 0.5 0.5
0.0103 1 0.5
0.0004 0.5 0.5
0.004 1 0.5
0.0007 0.5 0.5
0.0033 0.5 0.5
0.0075 1 1
0.0137 0.271 0.2294
0.0004 0.5 0.5
0.0051 0.5 0.5
0.0008 0.5 0.5
0.0011 0.5 0.5
0.0003 0.5 0.5
0.0004 0.5 0.5
0.0023 0.5 0.5
0.0004 0.5 0.5
0.0019 0.271 0
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0081 0.5 0.5
0.015 0.2827 0.5383
0.0082 0.5 0.5
0.0012 0.5 0.5
0.0059 0.6064 0.5
0.0053 1 1
0.0119 0.4458 0
0.0065 1 1
0.0032 1 0.5
0.0008 0.5 0.5
0.00184047 0.269186 0
0.000376403 0.5 0.5
0.0067 0.5 0.5
0.0004 0.5 0.5
0.0162 0.2769 0.9552
0.0176 0.3425 0.4215
0.0023 1 1
0.0388 0.2772 0.2713
0.0023 1 0.5
0.0011 0.5 0.5
0.0018 1 0.5
0.0004 0.5 0.5
0.0049 0.6682 0.6682
0.0111 0.3549 1
0.0004 0.5 0.5
0.0068 0.4312 1
0.0004 0.5 0.5
0.0346 0.2559 0.4077
0.0004 0.5 0.5
0.0062 0.5 0.5
0.0051 0.5 0.5
0.0007 0.5 0.5
0.0262 0.3083 0.7125
0.0027 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0038 0.5 0.5
0.0016 1 0.5
0.0042 1 1
0.0004 0.5 0.5
0.0059 0.5 0.5
0.0004 0.5 0.5
0.0038 1 0.5
0.0145 0.7126 0.5
0.007 0.3303 0.4717
0.0388 0.2772 0.2713
0.0079 0.2909 0.3548
0.0004 0.5 0.5
0.0075 0.3265 0.149
0.0102 0.3061 0.3937
0.0004 0.5 0.5
0.0026 0.5 0.5
0.007 1 1
0.015 0.2827 0.5383
0.0004 0.5 0.5
0.000376403 0.5 0.5
0.0004 0.5 0.5
0.0331 0.3985 0.9211
0.0073 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0087 1 1
0.0004 0.5 0.5
0.0008 0.5 0.5
0.002 1 0.5
0.0004 0.5 0.5
0.0103 0.6953 0.898
0.0057 0.2766 1
0.0033 0.5 0.5
0.0073 1 1
0.0004 0.5 0.5
0.0069 0.5 0.5
0.0052 0.3769 0.5
0.0368 0.2796 0.2661
0.0051 0.3758 1
0.0082 0.5 0.5
0.0075 0.2816 0.3367
0.0018 0.5 0.5
0.0122 0.4249 0.4197
0.0004 0.5 0.5
0.0082 0.5 0.5
0.0002 0.5 0.5
0.0004 0.5 0.5
0.0046 0.6591 1
0.0004 0.5 0.5
0.0066 1 1
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.003 0.3514 0.5
0.004 1 0.5
0.0004 0.5 0.5
0.0189 0.5524 0
0.0042 0.5 0.5
0.0018 0.2637 0.5
0.0033 0.3348 0.3348
0.0008 0.5 0.5
0.008 0.5 0.5
0.0235 0.3192 0.3992
0.0014 0.5 0.5
0.0015 0.5 0.5
0.01 0.5 0.5
0.0326 0.2819 0
0.0071 0.5 0.5
0.0074 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0007 0.5 0.5
0.0004 0.5 0.5
0.0067 0.5 0.5
0.00505219 0.5 0.5
0.0007 0.5 0.5
0.0068 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0228 0.2829 0
0.0025 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0052 0.2829 0.0114
0.0011 0.5 0.5
0.0068 1 1
0.0004 0.5 0.5
0.0156 0.4244 0.4244
0.0316 0.2652 0.2784
0.0004 0.5 0.5
0.00139338 1 0.5
0.0065 0.3393 0
0.0071 0.9628 0.5
0.0055 0.2887 0.3593
0.0029 1 1
0.0004 0.5 0.5
0.005 0.5 0.5
0.0021 0.4036 0
0.0133 0.2787 0.264
0.0037 0.2694 1
0.0018 0.2876 0.2876
0.0353 0.4928 1
0.0065 0.5 0.5
0.0036 0.4353 0.4353
0.0011 1 0.5
0.0019 0.5 0.5
0.0034 0.337 0.337
0.0032 0.5 0.5
0.0289 0.2916 0.389
0.006 0.2795 0.4558
0.0007 0.5 0.5
0.0004 0.5 0.5
0.008 0.2582 0.6941
0.026 0.251 0.2723
0.0019 0.271 0
0.033 0.3723 0.5186
0.0341 0.2689 0.2287
0.0049 0.293 0.6642
0.0044 0.4237 0.2755
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0046 0.5 0.5
0.015 0.3435 0
0.0063 0.4653 0.5
0.0004 0.5 0.5
0.036 0.2841 0.4156
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0042 0.3378 0
0.0058 0.5 0.5
0.0012 1 0.5
0.0004 0.5 0.5
0.0018 0.5004 0
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0316 0.2652 0.2784
0.0284 0.2924 0.419
0.0004 0.5 0.5
0.0569 0.2624 0.4601
0.0018 0.5 0.5
0.0047 0.6689 0.6689
0.0063 0.5 0.5
0.0007 0.5 0.5
0.0019 0.5 0.5
0.00777519 0.280873 0.259976
0.0059 0.6064 0.5
0.0047 0.6638 0.6638
0.0036 1 0.5
0.0081 0.5 0.5
0.0184 0.3352 0.5613
0.0055 0.5 0.5
0.0047 0.5 0.5
0.0004 0.5 0.5
0.0018 0.3602 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.30.3550 (Leishmania major), cytochrome p450-like protein
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