pI: 4.6463 |
Length (AA): 451 |
MW (Da): 49759 |
Paralog Number:
11
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | amastigotes, metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_126605)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G19770 | tubulin alpha-3 |
Arabidopsis thaliana | AT1G64740 | tubulin alpha-1 chain |
Arabidopsis thaliana | AT1G50010 | tubulin alpha-2 chain |
Arabidopsis thaliana | AT4G14960 | tubulin alpha-6 chain |
Arabidopsis thaliana | AT5G19780 | tubulin alpha-5 |
Arabidopsis thaliana | AT1G04820 | tubulin alpha-4 chain |
Babesia bovis | BBOV_IV004290 | tubulin alpha chain |
Babesia bovis | BBOV_III002820 | tubulin alpha chain, putative |
Brugia malayi | Bm1_25035 | Tubulin alpha-2 chain |
Brugia malayi | Bm1_55400 | Tubulin alpha-2 chain |
Brugia malayi | Bm1_20715 | tubulin alpha-2 chain |
Brugia malayi | Bm1_38680 | tubulin alpha chain - mouse |
Brugia malayi | Bm1_30260 | Tubulin alpha chain |
Brugia malayi | Bm1_12120 | alpha-tubulin |
Candida albicans | CaO19.7308 | cytoskeletal structural protein |
Caenorhabditis elegans | CELE_C44B11.3 | Protein MEC-12 |
Caenorhabditis elegans | CELE_ZK899.4 | Protein TBA-8 |
Caenorhabditis elegans | CELE_F16D3.1 | Protein TBA-5 |
Caenorhabditis elegans | CELE_C47B2.3 | Protein TBA-2 |
Caenorhabditis elegans | CELE_F26E4.8 | Protein TBA-1, isoform A |
Caenorhabditis elegans | CELE_F32H2.9 | Protein TBA-6 |
Caenorhabditis elegans | CELE_F40F4.5 | Protein TBA-9 |
Caenorhabditis elegans | CELE_T28D6.2 | Protein TBA-7 |
Caenorhabditis elegans | CELE_F44F4.11 | Protein TBA-4 |
Cryptosporidium hominis | Chro.40322 | alpha-tubulin |
Cryptosporidium parvum | cgd4_2860 | alpha tubulin |
Dictyostelium discoideum | DDB_G0281889 | hypothetical protein |
Dictyostelium discoideum | DDB_G0287689 | alpha tubulin |
Drosophila melanogaster | Dmel_CG1913 | alpha-Tubulin at 84B |
Drosophila melanogaster | Dmel_CG2512 | alpha-Tubulin at 84D |
Drosophila melanogaster | Dmel_CG8308 | alpha-Tubulin at 67C |
Drosophila melanogaster | Dmel_CG9476 | alpha-Tubulin at 85E |
Echinococcus granulosus | EgrG_000359200 | peroxisome assembly protein 26 |
Echinococcus granulosus | EgrG_000042500 | tubulin alpha 3 chain |
Echinococcus granulosus | EgrG_000340000 | tubulin alpha chain |
Echinococcus granulosus | EgrG_000042700 | tubulin alpha 1C chain |
Echinococcus granulosus | EgrG_000413200 | tubulin alpha 1C chain |
Echinococcus granulosus | EgrG_001070900 | tubulin alpha chain |
Echinococcus granulosus | EgrG_000352800 | alpha tubulin |
Echinococcus granulosus | EgrG_000042200 | Tubulin alpha 1 chain |
Echinococcus granulosus | EgrG_000042600 | tubulin alpha 3 chain |
Echinococcus granulosus | EgrG_000735000 | tubulin alpha chain |
Echinococcus granulosus | EgrG_001124100 | tubulin alpha chain |
Echinococcus granulosus | EgrG_000476400 | tubulin subunit TubB |
Echinococcus granulosus | EgrG_000886400 | tubulin alpha chain |
Echinococcus granulosus | EgrG_000040900 | Tubulin alpha 1 chain |
Echinococcus granulosus | EgrG_000588000 | Tubulin alpha 1 chain |
Entamoeba histolytica | EHI_010530 | tubulin alpha chain, putative |
Entamoeba histolytica | EHI_005950 | tubulin alpha-1 chain |
Echinococcus multilocularis | EmuJ_000042500 | tubulin alpha 3 chain |
Echinococcus multilocularis | EmuJ_001070900 | tubulin alpha chain |
Echinococcus multilocularis | EmuJ_000886400 | tubulin alpha chain |
Echinococcus multilocularis | EmuJ_000588000 | Tubulin alpha 1 chain |
Echinococcus multilocularis | EmuJ_000352800 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000340000 | tubulin alpha chain |
Echinococcus multilocularis | EmuJ_000040900 | Tubulin alpha 1 chain |
Echinococcus multilocularis | EmuJ_001124100 | tubulin alpha chain |
Echinococcus multilocularis | EmuJ_000042600 | tubulin alpha 3 chain |
Echinococcus multilocularis | EmuJ_000413200 | tubulin alpha 1C chain |
Echinococcus multilocularis | EmuJ_000042200 | Tubulin alpha 1 chain |
Echinococcus multilocularis | EmuJ_000476400 | tubulin subunit TubB |
Echinococcus multilocularis | EmuJ_000735000 | tubulin alpha chain |
Echinococcus multilocularis | EmuJ_000359200 | peroxisome assembly protein 26 |
Echinococcus multilocularis | EmuJ_000042700 | tubulin alpha 1C chain |
Giardia lamblia | GL50803_112079 | Alpha-tubulin |
Giardia lamblia | GL50803_103676 | Alpha-tubulin |
Homo sapiens | ENSG00000183785 | tubulin, alpha 8 |
Homo sapiens | ENSG00000167552 | tubulin, alpha 1a |
Homo sapiens | 101930571 | tubulin alpha-3E chain-like |
Homo sapiens | ENSG00000167553 | tubulin, alpha 1c |
Homo sapiens | ENSG00000152086 | tubulin, alpha 3e |
Homo sapiens | ENSG00000075886 | tubulin, alpha 3d |
Homo sapiens | ENSG00000123416 | tubulin, alpha 1b |
Homo sapiens | ENSG00000178462 | tubulin, alpha-like 3 |
Homo sapiens | ENSG00000127824 | tubulin, alpha 4a |
Homo sapiens | ENSG00000198033 | tubulin, alpha 3c |
Leishmania braziliensis | LbrM.13.0200 | alpha tubulin |
Leishmania braziliensis | LbrM.13.0190 | alpha tubulin |
Leishmania donovani | LdBPK_130330.1 | alpha tubulin |
Leishmania infantum | LinJ.13.0330 | alpha tubulin |
Leishmania infantum | LinJ.13.1460 | alpha tubulin |
Leishmania major | LmjF.13.0290 | alpha tubulin |
Leishmania major | LmjF.13.0300 | alpha tubulin |
Leishmania major | LmjF.13.0380 | alpha tubulin |
Leishmania major | LmjF.13.0390 | alpha tubulin |
Leishmania major | LmjF.13.0340 | alpha tubulin |
Leishmania major | LmjF.13.0310 | alpha tubulin |
Leishmania major | LmjF.13.0320 | alpha tubulin |
Leishmania major | LmjF.13.0330 | alpha tubulin |
Leishmania major | LmjF.13.0350 | alpha tubulin |
Leishmania major | LmjF.13.0280 | alpha tubulin |
Leishmania major | LmjF.13.0370 | alpha tubulin |
Leishmania major | LmjF.13.0360 | alpha tubulin |
Leishmania mexicana | LmxM.13.0280 | alpha tubulin |
Leishmania mexicana | LmxM.13.0390 | alpha tubulin |
Loa Loa (eye worm) | LOAG_02850 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15945 | tubulin alpha 2 |
Loa Loa (eye worm) | LOAG_16183 | hypothetical protein |
Loa Loa (eye worm) | LOAG_03501 | tubulin alpha-2 chain |
Loa Loa (eye worm) | LOAG_02725 | tubulin alpha chain |
Loa Loa (eye worm) | LOAG_15137 | tubulin alpha 2 |
Loa Loa (eye worm) | LOAG_15565 | alpha-tubulin isotype 2 |
Loa Loa (eye worm) | LOAG_13422 | tubulin alpha chain |
Loa Loa (eye worm) | LOAG_16296 | tubulin alpha 2 |
Loa Loa (eye worm) | LOAG_13355 | tubulin alpha-3 chain |
Loa Loa (eye worm) | LOAG_10553 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13743 | alpha-tubulin |
Loa Loa (eye worm) | LOAG_12328 | alpha-tubulin |
Mus musculus | ENSMUSG00000023004 | tubulin, alpha 1B |
Mus musculus | ENSMUSG00000021216 | tubulin, alpha-like 3 |
Mus musculus | ENSMUSG00000026202 | tubulin, alpha 4A |
Mus musculus | ENSMUSG00000067338 | tubulin, alpha 3B |
Mus musculus | ENSMUSG00000072235 | tubulin, alpha 1A |
Mus musculus | 53857 | tubulin, alpha 8 |
Mus musculus | ENSMUSG00000067702 | tubulin, alpha 3A |
Mus musculus | ENSMUSG00000043091 | tubulin, alpha 1C |
Neospora caninum | NCLIV_058890 | tubulin alpha chain |
Oryza sativa | 4343694 | Os07g0574800 |
Oryza sativa | 4332083 | Os03g0219300 |
Oryza sativa | 4333966 | Os03g0726100 |
Oryza sativa | 4350197 | Os11g0247300 |
Plasmodium berghei | PBANKA_0522700 | alpha tubulin 2 |
Plasmodium berghei | PBANKA_0417700 | alpha tubulin 1 |
Plasmodium falciparum | PF3D7_0903700 | alpha tubulin 1 |
Plasmodium falciparum | PF3D7_0422300 | alpha tubulin 2 |
Plasmodium knowlesi | PKNH_0701400 | alpha tubulin, putative |
Plasmodium knowlesi | PKNH_0514200 | alpha-tubulin II, putative |
Plasmodium vivax | PVX_098630 | tubulin alpha chain, putative |
Plasmodium vivax | PVX_090155 | tubulin alpha chain, putative |
Plasmodium yoelii | PY01155 | tubulin alpha chain |
Plasmodium yoelii | PY04063 | Tubulin/FtsZ family, putative |
Saccharomyces cerevisiae | YML085C | alpha-tubulin TUB1 |
Saccharomyces cerevisiae | YML124C | alpha-tubulin TUB3 |
Schistosoma japonicum | Sjp_0301890 | Tubulin alpha chain, putative |
Schistosoma japonicum | Sjp_0216350 | Tubulin alpha-1 chain, putative |
Schistosoma japonicum | Sjp_0049920 | Tubulin alpha-2/alpha-4 chain, putative |
Schistosoma japonicum | Sjp_0048410 | ko:K07374 tubulin alpha, putative |
Schistosoma japonicum | Sjp_0004280 | ko:K07374 tubulin alpha, putative |
Schistosoma japonicum | Sjp_0086780 | Tubulin alpha-1C chain, putative |
Schistosoma mansoni | Smp_090120.1 | alpha tubulin |
Schistosoma mansoni | Smp_090120.2 | alpha tubulin |
Schistosoma mansoni | Smp_103140 | alpha tubulin |
Schistosoma mansoni | Smp_016780 | tubulin subunit alpha |
Schistosoma mansoni | Smp_103790 | tubulin subunit alpha |
Schistosoma mansoni | Smp_027920 | tubulin subunit alpha |
Schmidtea mediterranea | mk4.001038.00 | |
Schmidtea mediterranea | mk4.015077.01 | |
Schmidtea mediterranea | mk4.000118.09 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.000742.01 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.001866.01 | |
Schmidtea mediterranea | mk4.001476.04 | |
Schmidtea mediterranea | mk4.031023.00 | |
Schmidtea mediterranea | mk4.000459.03 | |
Schmidtea mediterranea | mk4.004574.02 | |
Schmidtea mediterranea | mk4.003472.02 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.051830.00 | |
Schmidtea mediterranea | mk4.001818.00 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.000128.16 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.000393.17 | |
Schmidtea mediterranea | mk4.003554.05 | |
Schmidtea mediterranea | mk4.015303.00 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.033428.00 | |
Schmidtea mediterranea | mk4.008560.01 | |
Schmidtea mediterranea | mk4.011918.02 | |
Schmidtea mediterranea | mk4.000555.06 | |
Schmidtea mediterranea | mk4.035478.00 | |
Schmidtea mediterranea | mk4.005502.00 | |
Schmidtea mediterranea | mk4.000046.21 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.006425.01 | |
Schmidtea mediterranea | mk4.000382.00 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.032569.00 | |
Schmidtea mediterranea | mk4.000027.17 | |
Schmidtea mediterranea | mk4.016214.00 | |
Schmidtea mediterranea | mk4.017860.00 | |
Schmidtea mediterranea | mk4.000184.06 | |
Schmidtea mediterranea | mk4.022859.00 | |
Schmidtea mediterranea | mk4.002419.04 | |
Schmidtea mediterranea | mk4.013691.00 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.001011.04 | |
Schmidtea mediterranea | mk4.025283.00 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.023172.00 | |
Schmidtea mediterranea | mk4.010906.00 | |
Schmidtea mediterranea | mk4.003693.03 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.001331.03 | |
Schmidtea mediterranea | mk4.000840.07 | |
Schmidtea mediterranea | mk4.023807.01 | |
Schmidtea mediterranea | mk4.000118.07 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.000760.00 | |
Schmidtea mediterranea | mk4.002876.05 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.000400.01 | |
Schmidtea mediterranea | mk4.000840.06 | |
Schmidtea mediterranea | mk4.000397.06 | |
Schmidtea mediterranea | mk4.008598.00 | |
Schmidtea mediterranea | mk4.002422.01 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.013996.01 | |
Schmidtea mediterranea | mk4.020028.00 | |
Schmidtea mediterranea | mk4.022550.00 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.005316.03 | |
Schmidtea mediterranea | mk4.001170.01 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.003598.00 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.006425.00 | |
Schmidtea mediterranea | mk4.003257.03 | |
Schmidtea mediterranea | mk4.002655.05 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.018465.00 | |
Schmidtea mediterranea | mk4.000097.14 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.004071.00 | |
Schmidtea mediterranea | mk4.016278.00 | |
Schmidtea mediterranea | mk4.006568.00 | Alpha tubulin |
Schmidtea mediterranea | mk4.004071.03 | |
Schmidtea mediterranea | mk4.000783.08 | Tubulin alpha-4A chain |
Schmidtea mediterranea | mk4.003269.01 | |
Schmidtea mediterranea | mk4.005160.00 | Tuba7l protein |
Schmidtea mediterranea | mk4.003390.02 | |
Schmidtea mediterranea | mk4.007562.00 | |
Schmidtea mediterranea | mk4.006215.01 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.000778.04 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.000506.02 | |
Schmidtea mediterranea | mk4.004616.00 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.000695.03 | Tubulin alpha-4A chain |
Schmidtea mediterranea | mk4.003996.01 | |
Schmidtea mediterranea | mk4.029231.01 | |
Schmidtea mediterranea | mk4.000840.00 | |
Schmidtea mediterranea | mk4.014260.00 | Tubulin alpha-3 chain |
Schmidtea mediterranea | mk4.005525.02 | |
Schmidtea mediterranea | mk4.000268.07 | |
Schmidtea mediterranea | mk4.006825.00 | |
Schmidtea mediterranea | mk4.000955.02 | |
Schmidtea mediterranea | mk4.005086.00 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.001866.00 | |
Schmidtea mediterranea | mk4.000613.03 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.005160.02 | Alpha tubulin |
Schmidtea mediterranea | mk4.000030.19 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.000003.23 | |
Schmidtea mediterranea | mk4.003889.04 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.011565.02 | |
Schmidtea mediterranea | mk4.007951.00 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.003929.00 | |
Schmidtea mediterranea | mk4.001921.01 | |
Schmidtea mediterranea | mk4.033534.00 | |
Schmidtea mediterranea | mk4.001999.06 | |
Schmidtea mediterranea | mk4.000823.01 | |
Schmidtea mediterranea | mk4.013763.00 | |
Schmidtea mediterranea | mk4.022094.00 | |
Schmidtea mediterranea | mk4.001476.03 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.002621.00 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.003279.01 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.032380.00 | |
Schmidtea mediterranea | mk4.003356.00 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.020610.02 | |
Schmidtea mediterranea | mk4.014222.02 | |
Schmidtea mediterranea | mk4.004929.01 | |
Schmidtea mediterranea | mk4.001272.00 | |
Schmidtea mediterranea | mk4.034558.01 | |
Schmidtea mediterranea | mk4.000053.13 | |
Schmidtea mediterranea | mk4.006868.01 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.001169.02 | Putative tubulin alpha chain |
Schmidtea mediterranea | mk4.000101.10 | |
Schmidtea mediterranea | mk4.037833.00 | |
Schmidtea mediterranea | mk4.000855.03 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.003154.00 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.014871.00 | |
Schmidtea mediterranea | mk4.001759.06 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.019056.00 | |
Schmidtea mediterranea | mk4.000962.01 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.011078.00 | |
Schmidtea mediterranea | mk4.001192.09 | |
Schmidtea mediterranea | mk4.005473.04 | |
Schmidtea mediterranea | mk4.000000.21 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.000186.13 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.003938.02 | |
Schmidtea mediterranea | mk4.003482.02 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.028525.00 | |
Schmidtea mediterranea | mk4.001762.01 | |
Schmidtea mediterranea | mk4.003942.03 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.003482.03 | |
Schmidtea mediterranea | mk4.013482.00 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.008179.00 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.007757.00 | |
Schmidtea mediterranea | mk4.005830.01 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.001343.05 | |
Schmidtea mediterranea | mk4.048802.00 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.002300.08 | |
Schmidtea mediterranea | mk4.000470.10 | |
Schmidtea mediterranea | mk4.003942.04 | |
Schmidtea mediterranea | mk4.017512.01 | |
Schmidtea mediterranea | mk4.003937.04 | |
Schmidtea mediterranea | mk4.036982.00 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.000467.03 | |
Schmidtea mediterranea | mk4.004965.02 | |
Schmidtea mediterranea | mk4.000695.04 | Tubulin alpha-4A chain |
Schmidtea mediterranea | mk4.007932.00 | |
Schmidtea mediterranea | mk4.003853.00 | |
Schmidtea mediterranea | mk4.013009.01 | |
Schmidtea mediterranea | mk4.016475.00 | |
Schmidtea mediterranea | mk4.018496.00 | |
Schmidtea mediterranea | mk4.005380.00 | |
Schmidtea mediterranea | mk4.011462.00 | |
Schmidtea mediterranea | mk4.024688.00 | |
Schmidtea mediterranea | mk4.003269.02 | |
Schmidtea mediterranea | mk4.000470.09 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.004240.01 | |
Schmidtea mediterranea | mk4.006884.00 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.022625.00 | Tubulin alpha chain-like 3 |
Schmidtea mediterranea | mk4.015159.00 | |
Schmidtea mediterranea | mk4.000840.05 | |
Schmidtea mediterranea | mk4.004131.00 | |
Schmidtea mediterranea | mk4.017635.00 | |
Schmidtea mediterranea | mk4.015506.00 | |
Schmidtea mediterranea | mk4.003162.01 | Tubulin alpha chain-like 3 |
Trypanosoma brucei gambiense | Tbg972.1.1360 | alpha tubulin |
Trypanosoma brucei | Tb927.1.2340 | alpha tubulin |
Trypanosoma brucei | Tb927.1.2360 | alpha tubulin |
Trypanosoma brucei | Tb927.1.2400 | alpha tubulin |
Trypanosoma brucei | Tb927.1.2380 | alpha tubulin |
Trypanosoma congolense | TcIL3000_0_31230 | alpha tubulin |
Trypanosoma cruzi | TcCLB.411235.9 | alpha tubulin, putative |
Toxoplasma gondii | TGME49_316400 | alpha tubulin TUBA1 |
Toxoplasma gondii | TGME49_231770 | alpha-tubulin I, putative |
Theileria parva | TP01_0324 | tubulin alpha chain, putative |
Theileria parva | TP04_0093 | Tubulin alpha chain, putative |
Trichomonas vaginalis | TVAG_448410 | tubulin alpha-1 chain, putative |
Trichomonas vaginalis | TVAG_448390 | tubulin beta chain, putative |
Trichomonas vaginalis | TVAG_523980 | tubulin epsilon chain, putative |
Trichomonas vaginalis | TVAG_519620 | tubulin beta chain, putative |
Trichomonas vaginalis | TVAG_359090 | tubulin beta chain, putative |
Trichomonas vaginalis | TVAG_312330 | tubulin alpha-1 chain, putative |
Trichomonas vaginalis | TVAG_206890 | tubulin beta chain, putative |
Trichomonas vaginalis | TVAG_345420 | tubulin alpha-1 chain, putative |
Trichomonas vaginalis | TVAG_467840 | tubulin beta chain, putative |
Trichomonas vaginalis | TVAG_196270 | tubulin beta chain, putative |
Trichomonas vaginalis | TVAG_360870 | tubulin epsilon chain, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.1.2340 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.1.2340 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.1.2340 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.1.2340 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C44B11.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C44B11.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C44B11.3 | Caenorhabditis elegans | sterile | wormbase |
CELE_F26E4.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F26E4.8 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F26E4.8 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F26E4.8 | Caenorhabditis elegans | sterile | wormbase |
CELE_C47B2.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C47B2.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C47B2.3 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_C47B2.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C47B2.3 | Caenorhabditis elegans | sterile | wormbase |
CELE_F44F4.11 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F44F4.11 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F44F4.11 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F44F4.11 | Caenorhabditis elegans | sterile | wormbase |
YML085C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0417700 | Plasmodium berghei | Dispensable | plasmo |
PBANKA_0522700 | Plasmodium berghei | Essential | plasmo |
TGME49_231770 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_316400 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_231770 | Toxoplasma gondii | Probably essential | sidik |
TGME49_316400 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania amazonensis | No drug identifiers listed for this gene. |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 09/08/82. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; . | References: | 2392684 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania amazonensis | No drug identifiers listed for this gene. |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 09/08/82. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; . | References: | 2392684 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 79195 |
Annotator: | aaronjr@u.washington.edu. | Comment: | chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied. | References: | 2044859 | |
morphology (PATO:0000051) | abnormal (PATO:0000460) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from visible phenotype (ECO:0000176) | Leishmania mexicana | 79195 |
Annotator: | aaronjr@u.washington.edu. | Comment: | chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied. | References: | 2044859 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 79195 |
Annotator: | aaronjr@u.washington.edu. | Comment: | chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied. | References: | 2044859 | |
cell differentiation (GO:0030154) | disrupted (PATO:0001507) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 79195 |
Annotator: | aaronjr@u.washington.edu. | Comment: | chemical inhibition with antimicrotubule agents leads to disrupted differentiation from promastigote to amastigote of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied. | References: | 2044859 | |
growth (GO:0040007) | increased (PATO:0000470) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from loss-of-function mutant phenotype (ECO:0000016) | Leishmania enriettii | No drug identifiers listed for this gene. |
Annotator: | aaronjr@u.washington.edu. | Comment: | Genetic disruption of the alpha-tubulin gene array (+/-) increases transcription of the functional copy; targeted double KO cannot be generated due to genetic rearrangement to retain one WT copy, unless an episome is present that expresses a functional copy; unclear as to which topoisomerase II gene/enzyme was studied. | References: | 1429722 | |
syncytium formation by plasma membrane fusion (GO:0000768) | biosynthetic process (GO:0009058) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from loss-of-function mutant phenotype (ECO:0000016) | Leishmania enriettii | No drug identifiers listed for this gene. |
Annotator: | aaronjr@u.washington.edu. | Comment: | Genetic disruption of the alpha-tubulin gene array (+/-) increases transcription of the functional copy; targeted double KO cannot be generated due to genetic rearrangement to retain one WT copy, unless an episome is present that expresses a functional copy; unclear as to which topoisomerase II gene/enzyme was studied. | References: | 1429722 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania amazonensis | 586034 |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied. | References: | 8468004 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania amazonensis | 13316 39854 79195 544264 551075 552236 554547 555991 557331 559236 559237 559604 561797 562909 564379 564831 568817 568820 568821 569525 |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 29091-21-2. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied. | References: | 7818612 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania major | 39854 250338 536202 |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 121-50-6; Drug: 394-25-2; Drug: 14371-82-5; Drug: 22227-59-4; Drug: 174824-16-9; Drug: 176177-41-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied. | References: | 8849257 | |
microtubule polymerization (GO:0046785) | decreased (PATO:0000468) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from specific protein inhibition (ECO:0000020) | Leishmania amazonensis | 2976 8265 27599 67873 86876 250338 327961 371083 376038 543486 543487 559148 560712 572272 575226 588233 |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied. | References: | 10029309 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania amazonensis | 2976 8265 27599 67873 86876 250338 327961 371083 376038 543486 543487 559148 560712 572272 575226 588233 |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied. | References: | 10029309 | |
microtubule polymerization (GO:0046785) | increased (PATO:0000470) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania donovani | 2976 8265 559148 |
Annotator: | aaronjr@u.washington.edu. | Comment: | chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied. | References: | 10427726 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania donovani | 2976 8265 559148 |
Annotator: | aaronjr@u.washington.edu. | Comment: | chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied. | References: | 10427726 | |
growth (GO:0040007) | drug insensitive (PATO:0000528) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania donovani | 2976 8265 559148 |
Annotator: | aaronjr@u.washington.edu. | Comment: | chemical inhibition with microtubule stabilising agent generated cell line resistant to drug with a MDR phenotype; reversible with Ca2+-channel blocker verapamil; unclear as to which topoisomerase II gene/enzyme was studied. | References: | 10427727 | |
growth (GO:0040007) | drug insensitive (PATO:0000528) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 37094 39854 79195 250338 551075 562909 |
Annotator: | aaronjr@u.washington.edu. | Comment: | chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied. | References: | 10546848 | |
microtubule polymerization (GO:0046785) | decreased (PATO:0000468) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from specific protein inhibition (ECO:0000020) | Leishmania donovani | 2976 8265 80107 559148 576689 576690 |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 313705-89-4; Drug: 157207-90-4. chemical inhibition with antimicrotubule agents leads to abnormal cell morphology, cell division, mitosis, organelle localization & organization, and slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied. | References: | 11071278 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania donovani | 2976 8265 80107 559148 576689 576690 |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 313705-89-4; Drug: 157207-90-4. chemical inhibition with antimicrotubule agents leads to abnormal cell morphology, cell division, mitosis, organelle localization & organization, and slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied. | References: | 11071278 | |
cytokinesis (GO:0000910) | discontinuous (PATO:0000690) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from visible phenotype (ECO:0000176) | Leishmania donovani | 2976 8265 80107 559148 576689 576690 |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 313705-89-4; Drug: 157207-90-4. chemical inhibition with antimicrotubule agents leads to abnormal cell morphology, cell division, mitosis, organelle localization & organization, and slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied. | References: | 11071278 | |
mitotic sister chromatid segregation (GO:0000070) | discontinuous (PATO:0000690) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from visible phenotype (ECO:0000176) | Leishmania donovani | 2976 8265 80107 559148 576689 576690 |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 313705-89-4; Drug: 157207-90-4. chemical inhibition with antimicrotubule agents leads to abnormal cell morphology, cell division, mitosis, organelle localization & organization, and slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied. | References: | 11071278 | |
organelle localization (GO:0051640) | discontinuous (PATO:0000690) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from visible phenotype (ECO:0000176) | Leishmania donovani | 2976 8265 80107 559148 576689 576690 |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 313705-89-4; Drug: 157207-90-4. chemical inhibition with antimicrotubule agents leads to abnormal cell morphology, cell division, mitosis, organelle localization & organization, and slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied. | References: | 11071278 | |
morphology (PATO:0000051) | abnormal (PATO:0000460) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from visible phenotype (ECO:0000176) | Leishmania donovani | 2976 8265 80107 559148 576689 576690 |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 313705-89-4; Drug: 157207-90-4. chemical inhibition with antimicrotubule agents leads to abnormal cell morphology, cell division, mitosis, organelle localization & organization, and slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied. | References: | 11071278 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania donovani | 12596 13316 15907 26907 78691 79195 527824 528258 531885 531886 532164 532165 532166 532195 532196 532197 532198 532199 532642 532643 532644 536969 536970 544264 552236 554547 559604 561797 564379 568817 568820 568821 |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied. | References: | 12161141 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania donovani | 12596 13316 15907 26907 78691 79195 527824 528258 531885 531886 532164 532165 532166 532195 532196 532197 532198 532199 532642 532643 532644 536969 536970 544264 552236 554547 559604 561797 564379 568817 568820 568821 |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied. | References: | 12161141 | |
microtubule polymerization (GO:0046785) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Leishmania donovani | 12596 13316 15907 26907 78691 79195 527824 528258 531885 531886 532164 532165 532166 532195 532196 532197 532198 532199 532642 532643 532644 536969 536970 544264 552236 554547 559604 561797 564379 568817 568820 568821 | |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied. | References: | 12161141 | |
cell cycle arrest (GO:0007050) | abnormal (PATO:0000460) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania donovani | 79195 |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 483279-40-9; Drug: 483279-44-3. chemical inhibition with antimicrotubule agents leads to cell cycle arrest in cell assay; unclear as to which topoisomerase II gene/enzyme was studied. | References: | 14645662 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania donovani | 79195 |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 19044-89-4; Drug: 19044-94-1; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 619267-13-9; Drug: 619267-14-0; Drug: 619267-15-1; Drug: 619267-16-2; Drug: 619267-17-3; Drug: 619267-18-4; Drug: 619267-19-5; Drug: 619267-20-8; Drug: 619267-21-9; Drug: 619267-22-0; Drug: 619267-23-1; Drug: 619267-24-2; Drug: 619267-25-3; Drug: 619267-26-4; Drug: 678187-02-5; Drug: 678187-03-6; Drug: 678187-04-7; Drug: 678187-05-8; Drug: 678187-06-9; Drug: 678187-07-0; Drug: 678187-08-1; Drug: 678187-09-2; Drug: 678187-10-5; Drug: 678187-11-6; Drug: 678187-12-7; Drug: 678187-13-8; Drug: 678187-14-9. chemical inhibition with antimicrotubule agents leads to cell cycle arrest in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied. | References: | 15027874 | |
microtubule polymerization (GO:0046785) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Leishmania donovani | 79195 | |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 19044-89-4; Drug: 19044-94-1; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 619267-13-9; Drug: 619267-14-0; Drug: 619267-15-1; Drug: 619267-16-2; Drug: 619267-17-3; Drug: 619267-18-4; Drug: 619267-19-5; Drug: 619267-20-8; Drug: 619267-21-9; Drug: 619267-22-0; Drug: 619267-23-1; Drug: 619267-24-2; Drug: 619267-25-3; Drug: 619267-26-4; Drug: 678187-02-5; Drug: 678187-03-6; Drug: 678187-04-7; Drug: 678187-05-8; Drug: 678187-06-9; Drug: 678187-07-0; Drug: 678187-08-1; Drug: 678187-09-2; Drug: 678187-10-5; Drug: 678187-11-6; Drug: 678187-12-7; Drug: 678187-13-8; Drug: 678187-14-9. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied. | References: | 15027874 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania donovani | No drug identifiers listed for this gene. |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 902779-03-7; Drug: 908843-57-2; Drug: 908843-58-3; Drug: 908843-61-8; Drug: 908843-63-0; Drug: 908843-68-5; Drug: 908843-70-9; Drug: 908843-73-2; Drug: 908843-74-3; Drug: 908843-75-4; Drug: 908843-76-5; Drug: 908843-77-6; Drug: 908843-78-7; Drug: 908843-79-8; Drug: 908843-80-1; Drug: 908843-81-2; Drug: 908843-82-3; Drug: 908843-84-5. chemical inhibition with antimicrotubule agents leads to cell cycle arrest in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied. | References: | 16675220 | |
microtubule polymerization (GO:0046785) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Leishmania donovani | No drug identifiers listed for this gene. | |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 902779-03-7; Drug: 908843-57-2; Drug: 908843-58-3; Drug: 908843-61-8; Drug: 908843-63-0; Drug: 908843-68-5; Drug: 908843-70-9; Drug: 908843-73-2; Drug: 908843-74-3; Drug: 908843-75-4; Drug: 908843-76-5; Drug: 908843-77-6; Drug: 908843-78-7; Drug: 908843-79-8; Drug: 908843-80-1; Drug: 908843-81-2; Drug: 908843-82-3; Drug: 908843-84-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied. | References: | 16675220 | |
microtubule polymerization (GO:0046785) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Leishmania tarentolae | 79195 | |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 483279-44-3; Drug: 619267-15-1. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied. | References: | 16753146 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 449723 |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied. | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 449723 |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied. | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 449723 |
Annotator: | aaronjr@u.washington.edu. | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied. | References: | 16918078 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.8
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Sus scrofa | Tubulin | 445 aa | 40.6% | 434 aa | Compounds | References |
Bos taurus | Tubulin | 85 aa | 69.8% | 86 aa | Compounds | References |
Leishmania donovani | Beta tubulin | 43 aa | 43.6% | 39 aa | Compounds | References |
Bos taurus | Tubulin beta chain | 445 aa | 40.6% | 434 aa | Compounds | References |