Detailed view for TcCLB.510669.20

Basic information

TDR Targets ID: 30046
Trypanosoma cruzi, glycosomal membrane protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.6442 | Length (AA): 244 | MW (Da): 26575 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05648   Peroxisomal biogenesis factor 11 (PEX11)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005779   integral to peroxisomal membrane  
GO:0016559   peroxisome fission  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_139863)

Species Accession Gene Product
Leishmania braziliensis LbrM.34.3680   Gim5A protein, putative,glycosomal membrane protein
Leishmania donovani LdBPK_353750.1   Gim5A protein, putative
Leishmania infantum LinJ.35.3750   Gim5A protein, putative,glycosomal membrane protein
Leishmania major LmjF.35.3700   Gim5A protein, putative,glycosomal membrane protein
Leishmania mexicana LmxM.34.3700   Gim5A protein, putative,glycosomal membrane protein
Trypanosoma brucei gambiense Tbg972.9.6900   Gim5A protein,glycosomal membrane protein, putative
Trypanosoma brucei gambiense Tbg972.9.6910   Gim5B protein,glycosomal membrane protein, putative
Trypanosoma brucei Tb927.9.11600   glycosomal membrane protein
Trypanosoma brucei Tb927.9.11580   glycosomal membrane protein
Trypanosoma congolense TcIL3000_0_58140   Gim5A protein
Trypanosoma cruzi TcCLB.508461.570   glycosomal membrane protein, putative
Trypanosoma cruzi TcCLB.510669.20   glycosomal membrane protein, putative
Trypanosoma cruzi TcCLB.510669.49   Gim5A protein, putative
Trypanosoma cruzi TcCLB.507009.10   Gim5A protein, putative

Essentiality

TcCLB.510669.20 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.2740 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.211.2740 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.211.2740 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.211.2740 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb09.211.2730 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.211.2730 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.211.2730 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.211.2730 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.510669.20 (Trypanosoma cruzi), glycosomal membrane protein, putative
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