Detailed view for TcCLB.511069.20

Basic information

TDR Targets ID: 30099
Trypanosoma cruzi, 40S ribosomal protein S8, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 11.4106 | Length (AA): 221 | MW (Da): 25112 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01201   Ribosomal protein S8e

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 220 4kzy (I) 2 206 53.00 0 1 1.48705 0.65

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_127039)

Species Accession Gene Product
Arabidopsis thaliana AT5G20290   40S ribosomal protein S8-1
Arabidopsis thaliana AT5G59240   40S ribosomal protein S8-2
Babesia bovis BBOV_IV000190   40S ribosomal protein S8
Brugia malayi Bm1_11120   40S ribosomal protein S8
Candida albicans CaO19.6873   likely cytosolic ribosomal protein similar to S. cerevisiae RPS8A (YBL072C) and RPS8B (YER102W) small subunit protein
Candida albicans CaO19.14162   likely cytosolic ribosomal protein similar to S. cerevisiae RPS8A (YBL072C) and RPS8B (YER102W) small subunit protein
Caenorhabditis elegans CELE_F42C5.8   Protein RPS-8
Cryptosporidium hominis Chro.60531   ribosomal protein S8
Cryptosporidium parvum cgd6_4630   40S ribosomal protein S8
Dictyostelium discoideum DDB_G0291864   40S ribosomal protein S8
Drosophila melanogaster Dmel_CG7808   Ribosomal protein S8
Echinococcus granulosus EgrG_000331100   40S ribosomal protein S8
Entamoeba histolytica EHI_053190   hypothetical protein, conserved
Entamoeba histolytica EHI_009870   hypothetical protein, conserved
Entamoeba histolytica EHI_086510   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000331100   40S ribosomal protein S8
Giardia lamblia GL50803_5845   Ribosomal protein S8
Homo sapiens ENSG00000142937   ribosomal protein S8
Homo sapiens 102724737   40S ribosomal protein S8-like
Leishmania braziliensis LbrM.24.2150   40S ribosomal protein S8, putative
Leishmania braziliensis LbrM.24.2160   40S ribosomal protein S8, putative
Leishmania donovani LdBPK_242160.1   40S ribosomal protein S8, putative
Leishmania infantum LinJ.24.2170   40S ribosomal protein S8, putative
Leishmania infantum LinJ.24.2160   40S ribosomal protein S8, putative
Leishmania major LmjF.24.2080   40S ribosomal protein S8, putative
Leishmania major LmjF.24.2070   40S ribosomal protein S8, putative
Leishmania mexicana LmxM.24.2070   40S ribosomal protein S8, putative
Leishmania mexicana LmxM.24.2080   40S ribosomal protein S8, putative
Loa Loa (eye worm) LOAG_06527   40S ribosomal protein S8
Mus musculus 101055915   40S ribosomal protein S8-like
Mus musculus 102636216   predicted gene 29257
Mus musculus ENSMUSG00000047675   ribosomal protein S8
Neospora caninum NCLIV_062720   hypothetical protein
Oryza sativa 4335547   Os04g0349500
Oryza sativa 4329381   Os02g0489400
Onchocerca volvulus OVOC1926   40S ribosomal protein S8 homolog
Plasmodium berghei PBANKA_1033900   40S ribosomal protein S8e, putative
Plasmodium falciparum PF3D7_1408600   40S ribosomal protein S8e, putative
Plasmodium knowlesi PKNH_1349800   40S ribosomal protein S8e, putative
Plasmodium vivax PVX_086020   40S ribosomal protein S8e, putative
Plasmodium yoelii PY01682   Ribosomal protein S8e, putative
Saccharomyces cerevisiae YER102W   ribosomal 40S subunit protein S8B
Saccharomyces cerevisiae YBL072C   ribosomal 40S subunit protein S8A
Schistosoma japonicum Sjp_0101740   ko:K02995 small subunit ribosomal protein S8e, putative
Schistosoma mansoni Smp_054780   40S ribosomal protein S8
Schmidtea mediterranea mk4.000745.03   40S ribosomal protein S8
Trypanosoma brucei gambiense Tbg972.8.6210   40S ribosomal protein S8, putative
Trypanosoma brucei gambiense Tbg972.8.6220   40S ribosomal protein S8, putative
Trypanosoma brucei Tb927.8.6150   40S ribosomal protein S8, putative
Trypanosoma brucei Tb927.8.6160   40S ribosomal protein S8, putative
Trypanosoma congolense TcIL3000_8_6000   40S ribosomal protein S8, putative
Trypanosoma congolense TcIL3000_8_6010   40S ribosomal protein S8, putative
Trypanosoma cruzi TcCLB.511069.10   40S ribosomal protein S8, putative
Trypanosoma cruzi TcCLB.511903.110   40S ribosomal protein S8, putative
Trypanosoma cruzi TcCLB.511069.20   40S ribosomal protein S8, putative
Toxoplasma gondii TGME49_245460   ribosomal protein RPS8
Theileria parva TP02_0949   40S ribosomal protein S8e, putative
Trichomonas vaginalis TVAG_435430   40S ribosomal protein S8, putative
Trichomonas vaginalis TVAG_206300   40S ribosomal protein S8, putative
Trichomonas vaginalis TVAG_066030   40S ribosomal protein S8, putative
Trichomonas vaginalis TVAG_164160   40S ribosomal protein S8, putative

Essentiality

TcCLB.511069.20 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.6150 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.8.6150 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.6150 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.8.6150 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F42C5.8 Caenorhabditis elegans larval arrest wormbase
CELE_F42C5.8 Caenorhabditis elegans slow growth wormbase
CELE_F42C5.8 Caenorhabditis elegans sterile wormbase
PBANKA_1033900 Plasmodium berghei Essential plasmo
TGME49_245460 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.511069.20 (Trypanosoma cruzi), 40S ribosomal protein S8, putative
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