pI: 10.44 |
Length (AA): 142 |
MW (Da): 14919 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
19 | 86 | 1g6p (A) | 2 | 66 | 38.00 | 0 | 1 | 0.89 | -0.33 |
22 | 84 | 1mjc () | 8 | 69 | 44.00 | 0.000000022 | 1 | 1.03 | -1 |
13 | 94 | 3ulj (A) | 28 | 114 | 34.00 | 0.000071 | 1 | 0.971465 | -1.19 |
18 | 85 | 1mjc (A) | 5 | 70 | 42.00 | 0.000000015 | 1 | 1.03787 | -1.24 |
19 | 83 | 2lss (A) | 6 | 68 | 41.00 | 0 | 1 | 1.02105 | -1.08 |
19 | 84 | 3i2z (B) | 5 | 68 | 48.00 | 0.0000000022 | 1 | 1.12519 | -1.17 |
99 | 134 | 3bog (C) | 3 | 76 | 61.00 | 0.0000033 | 0.12 | 0.854921 | 0.14 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | epimastigote, metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_126866)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G38680 | glycine rich protein 2 |
Arabidopsis thaliana | AT2G21060 | glycine-rich protein 2B |
Brugia malayi | Bm1_57515 | 'Cold-shock' DNA-binding domain containing protein |
Caenorhabditis elegans | CELE_M01E11.5 | Protein CEY-3 |
Caenorhabditis elegans | CELE_F33A8.3 | Protein CEY-1 |
Cryptosporidium hominis | Chro.80275 | glycogen debranching enzyme |
Cryptosporidium parvum | cgd8_2340 | cold shock RNA binding domain of the OB fold |
Drosophila melanogaster | Dmel_CG5654 | ypsilon schachtel |
Escherichia coli | b1823 | stress protein, member of the CspA-family |
Escherichia coli | b3556 | RNA chaperone and antiterminator, cold-inducible |
Escherichia coli | b0623 | constitutive cold shock family transcription antitermination protein |
Escherichia coli | b1557 | Qin prophage |
Escherichia coli | b0990 | cold shock protein homolog, cold-inducible |
Escherichia coli | b0880 | inhibitor of DNA replication, cold shock protein homolog |
Echinococcus multilocularis | EmuJ_000490500 | nuclease sensitive element binding protein |
Homo sapiens | ENSG00000065978 | Y box binding protein 1 |
Homo sapiens | ENSG00000060138 | Y box binding protein 3 |
Leishmania braziliensis | LbrM.28.0880 | RNA binding protein rbp16, putative |
Leishmania donovani | LdBPK_280900.1 | RNA binding protein rbp16, putative |
Leishmania infantum | LinJ.28.0900 | RNA binding protein rbp16, putative |
Leishmania major | LmjF.28.0825 | RNA binding protein rbp16, putative |
Leishmania mexicana | LmxM.28.0825 | RNA binding protein rbp16, putative |
Loa Loa (eye worm) | LOAG_13658 | hypothetical protein |
Loa Loa (eye worm) | LOAG_11791 | cold-shock DNA-binding domain-containing protein |
Mycobacterium leprae | ML0198 | Probable cold shock protein A CspA |
Mus musculus | ENSMUSG00000028639 | Y box protein 1 |
Mus musculus | ENSMUSG00000030189 | Y box protein 3 |
Mycobacterium tuberculosis | Rv3648c | Probable cold shock protein A CspA |
Mycobacterium ulcerans | MUL_0392 | cold shock protein a, CspA |
Mycobacterium ulcerans | MUL_0035 | DNA-binding protein |
Mycobacterium ulcerans | MUL_4224 | cold-shock protein |
Neospora caninum | NCLIV_038710 | Lin-28 homolog B, related |
Neospora caninum | NCLIV_009670 | Cold-shock protein, DNA-binding, related |
Schistosoma japonicum | Sjp_0026800 | DNA-binding protein A, putative |
Schistosoma japonicum | Sjp_0200260 | ko:K03704 cold shock protein (beta-ribbon, CspA family), putative |
Schistosoma mansoni | Smp_097800.2 | Y box binding protein |
Schistosoma mansoni | Smp_097750 | cold shock domain protein A |
Schistosoma mansoni | Smp_097800.1 | Y box binding protein |
Schistosoma mansoni | Smp_097800.3 | Y box binding protein |
Schmidtea mediterranea | mk4.003076.00 | |
Schmidtea mediterranea | mk4.009099.00 | Y box protein 4-like protein |
Schmidtea mediterranea | mk4.000460.10 | Ypsilon schachtel |
Schmidtea mediterranea | mk4.001190.00 | Ypsilon schachtel |
Schmidtea mediterranea | mk4.012571.02 | Ypsilon schachtel |
Schmidtea mediterranea | mk4.000038.07 | |
Schmidtea mediterranea | mk4.000460.12 | Ypsilon schachtel |
Schmidtea mediterranea | mk4.023560.00 | Ypsilon schachtel |
Schmidtea mediterranea | mk4.002197.00 | Ypsilon schachtel |
Schmidtea mediterranea | mk4.006230.01 | |
Schmidtea mediterranea | mk4.011408.00 | |
Schmidtea mediterranea | mk4.010663.00 | |
Schmidtea mediterranea | mk4.005229.03 | |
Schmidtea mediterranea | mk4.001230.07 | Ypsilon schachtel |
Schmidtea mediterranea | mk4.001259.05 | |
Trypanosoma brucei gambiense | Tbg972.11.9010 | mitochondrial RNA binding protein,RBP16,RNA- binding protein of 16 kDa, putative |
Trypanosoma brucei | Tb927.11.7900 | mitochondrial RNA binding protein 16 |
Trypanosoma cruzi | TcCLB.506933.60 | mitochondrial RNA binding protein, putative |
Toxoplasma gondii | TGME49_320600 | cold-shock DNA-binding domain-containing protein |
Toxoplasma gondii | TGME49_267470 | cold-shock DNA-binding domain-containing protein |
Theileria parva | TP03_0570 | cold shock protein, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0707 | cold shock protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu3710 | Mycobacterium tuberculosis | essential | nmpdr |
Tb11.02.5770 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.5770 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.5770 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.02.5770 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0623 | Escherichia coli | non-essential | goodall |
b0880 | Escherichia coli | non-essential | goodall |
b0990 | Escherichia coli | non-essential | goodall |
b1557 | Escherichia coli | non-essential | goodall |
b1823 | Escherichia coli | non-essential | goodall |
b3556 | Escherichia coli | non-essential | goodall |
TGME49_267470 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_320600 | Toxoplasma gondii | Probably non-essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.