Detailed view for TcCLB.506401.120

Basic information

TDR Targets ID: 30510
Trypanosoma cruzi, 40S ribosomal protein S9, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 11.1401 | Length (AA): 190 | MW (Da): 22134 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00163   Ribosomal protein S4/S9 N-terminal domain
PF01479   S4 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0015935   small ribosomal subunit  
GO:0005622   intracellular  
GO:0019843   rRNA binding  
GO:0003735   structural constituent of ribosome  
GO:0003723   RNA binding  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
37 181 1fjg (D) 34 167 32.00 0 0.6 1.01 0.42
102 169 2cqj (A) 105 172 31.00 0 0.98 0.78 -1.47
8 186 4kzy (J) 10 188 61.00 0 1 1.62341 0.19
25 159 5wxm (A) 28 162 22.00 0.000000062 0.68 1.04013 -0.53
104 152 1dm9 (A) 7 54 25.00 0 0.76 0.487095 0.49

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_126983)

Species Accession Gene Product
Arabidopsis thaliana AT5G39850   40S ribosomal protein S9-2
Arabidopsis thaliana AT5G15200   40S ribosomal protein S9-1
Babesia bovis BBOV_II002670   40S ribosomal subunit protein S9, putative
Brugia malayi Bm1_15065   40S ribosomal protein S9
Candida albicans CaO19.8459   potential cytosolic ribosomal protein similar to S. cerevisiae RPS9B (YBR189W) and RPS9A (YPL081W) small subunit protein S9 (E.
Caenorhabditis elegans CELE_F40F8.10   Protein RPS-9
Cryptosporidium hominis Chro.80213   40S ribosomal subunit protein S9
Cryptosporidium parvum cgd8_1840   40S ribosomal subunit protein S9, putative
Dictyostelium discoideum DDB_G0289877   40S ribosomal protein S9
Drosophila melanogaster Dmel_CG3395   Ribosomal protein S9
Echinococcus granulosus EgrG_000430500   40S ribosomal protein S9
Entamoeba histolytica EHI_179000   40S ribosomal protein S9
Entamoeba histolytica EHI_125780   40S ribosomal protein S9
Entamoeba histolytica EHI_152610   40S ribosomal protein S9
Entamoeba histolytica EHI_152080   40S ribosomal protein S9
Echinococcus multilocularis EmuJ_000430500   40S ribosomal protein S9
Giardia lamblia GL50803_4547   Ribosomal protein S9
Homo sapiens ENSG00000170889   ribosomal protein S9
Leishmania braziliensis LbrM.35.1380   40S ribosomal protein S9, putative
Leishmania braziliensis LbrM.07.0750   40S ribosomal protein S9, putative
Leishmania donovani LdBPK_361310.1   40S ribosomal protein S9, putative
Leishmania infantum LinJ.36.1310   40S ribosomal protein S9, putative
Leishmania infantum LinJ.07.0760   40S ribosomal protein S9, putative
Leishmania major LmjF.36.1250   40S ribosomal protein S9, putative
Leishmania major LmjF.07.0680   40S ribosomal protein S9, putative
Leishmania mexicana LmxM.36.1250   40S ribosomal protein S9, putative
Loa Loa (eye worm) LOAG_12353   40S ribosomal protein S9
Mus musculus ENSMUSG00000006333   ribosomal protein S9
Neospora caninum NCLIV_064440   hypothetical protein
Oryza sativa 9268088   Os11g0602501
Oryza sativa 4350869   Os11g0602600
Oryza sativa 4331662   Os03g0154700
Plasmodium berghei PBANKA_1234800   40S ribosomal protein S9, putative
Plasmodium falciparum PF3D7_0520000   40S ribosomal protein S9, putative
Plasmodium knowlesi PKNH_1013100   40S ribosomal protein S9, putative
Plasmodium vivax PVX_080245   40S ribosomal protein S9, putative
Plasmodium yoelii PY02191   ribosomal protein S4, putative
Saccharomyces cerevisiae YBR189W   ribosomal 40S subunit protein S9B
Saccharomyces cerevisiae YPL081W   ribosomal 40S subunit protein S9A
Schistosoma japonicum Sjp_0304980   ko:K02997 small subunit ribosomal protein S9e, putative
Schistosoma mansoni Smp_180000   40S ribosomal protein S9
Schmidtea mediterranea mk4.000094.07   40S ribosomal protein S9
Trypanosoma brucei gambiense Tbg972.8.670   40S ribosomal protein S9, putative
Trypanosoma brucei gambiense Tbg972.10.6820   40S ribosomal protein S9, putative
Trypanosoma brucei Tb927.10.5610   40S ribosomal protein S9, putative
Trypanosoma brucei Tb927.8.1110   40S ribosomal protein S9, putative
Trypanosoma congolense TcIL3000_8_730   40S ribosomal protein S9, putative
Trypanosoma cruzi TcCLB.506401.120   40S ribosomal protein S9, putative
Trypanosoma cruzi TcCLB.508543.30   40S ribosomal protein S9, putative
Trypanosoma cruzi TcCLB.504163.30   40S ribosomal protein S9, putative
Toxoplasma gondii TGME49_248480   ribosomal protein RPS9
Theileria parva TP04_0309   40S ribosomal protein S9, putative
Trichomonas vaginalis TVAG_259540   40S ribosomal protein S9, putative
Trichomonas vaginalis TVAG_204300   40S ribosomal protein S9, putative
Trichomonas vaginalis TVAG_204310   30S 40S ribosomal protein, putative
Trichomonas vaginalis TVAG_173990   30S 40S ribosomal protein, putative
Trichomonas vaginalis TVAG_010560   30S 40S ribosomal protein, putative
Trichomonas vaginalis TVAG_495360   30S 40S ribosomal protein, putative
Trichomonas vaginalis TVAG_041350   30S 40S ribosomal protein, putative
Trichomonas vaginalis TVAG_474000   30S ribosomal protein S4p, putative
Trichomonas vaginalis TVAG_139990   30S ribosomal protein S4p, putative

Essentiality

TcCLB.506401.120 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.1110 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.8.1110 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.1110 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.8.1110 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.5610 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.5610 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.5610 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.5610 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F40F8.10 Caenorhabditis elegans adult lethal wormbase
CELE_F40F8.10 Caenorhabditis elegans embryonic lethal wormbase
CELE_F40F8.10 Caenorhabditis elegans larval arrest wormbase
CELE_F40F8.10 Caenorhabditis elegans larval lethal wormbase
CELE_F40F8.10 Caenorhabditis elegans slow growth wormbase
CELE_F40F8.10 Caenorhabditis elegans sterile wormbase
TGME49_248480 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TcCLB.506401.120 (Trypanosoma cruzi), 40S ribosomal protein S9, putative
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