Detailed view for TcCLB.506885.80

Basic information

TDR Targets ID: 31534
Trypanosoma cruzi, hypothetical protein
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.5885 | Length (AA): 209 | MW (Da): 23311 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02902   Ulp1 protease family, C-terminal catalytic domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008234   cysteine-type peptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 207 1th0 (A) 393 586 20.00 0 1 1.1 -0.87
2 206 2bkr (A) 9 208 18.00 0 0.91 1.21 -1.12
1 208 1euv (A) 430 619 22.00 0 0.99 1.17592 -0.36
72 207 3zo5 (A) 474 592 29.00 0.12 0.78 0.557918 0.63

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_129942)

Species Accession Gene Product
Arabidopsis thaliana AT5G60190   NEDD8-specific protease 1
Brugia malayi Bm1_36415   Ulp1 protease family, C-terminal catalytic domain containing protein
Candida albicans CaO19.7986   one of three potential ubiquitin-like protein-specific protease genes
Candida albicans CaO19.353   one of three potential ubiquitin-like protein-specific protease genes
Caenorhabditis elegans CELE_Y48A5A.2   Protein ULP-3
Dictyostelium discoideum DDB_G0278795   sentrin-specific protease 8
Drosophila melanogaster Dmel_CG8493   Deneddylase 1
Echinococcus granulosus EgrG_001069800   sentrin specific protease 8
Entamoeba histolytica EHI_166820   Ulp1 protease family, C-terminal catalytic domain containing protein
Echinococcus multilocularis EmuJ_001069800   sentrin specific protease 8
Homo sapiens ENSG00000166192   SUMO/sentrin specific peptidase family member 8
Loa Loa (eye worm) LOAG_02316   Ulp1 protease
Mus musculus ENSMUSG00000051705   SUMO/sentrin specific peptidase 8
Neospora caninum NCLIV_037220   hypothetical protein
Oryza sativa 4351243   Os12g0102300
Oryza sativa 4349534   Os11g0102700
Oryza sativa 9267630   Os12g0103450
Oryza sativa 9270954   Os11g0102650
Schistosoma japonicum Sjp_0112700   ko:K08597 sentrin-specific protease 8, putative
Schistosoma mansoni Smp_121890   family C48 unassigned peptidase (C48 family)
Schmidtea mediterranea mk4.000321.05   Family C48 unassigned peptidase
Trypanosoma cruzi TcCLB.506885.80   hypothetical protein
Trichomonas vaginalis TVAG_011460   Clan CE, family C48, Ulp1-like cysteine peptidase
Trichomonas vaginalis TVAG_008810   Clan CE, family C48, Ulp1-like cysteine peptidase
Trichomonas vaginalis TVAG_233370   Sentrin-specific protease, putative
Trichomonas vaginalis TVAG_246590   Clan CE, family C48, Ulp1-like cysteine peptidase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens SUMO/sentrin specific peptidase family member 8 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0522 0.5179 0.8308
0.0221 0.2705 1
0.008 0.3418 1
0.0067 0.7395 1
0.0111 0.5084 1
0.0048 0.352 0.6829
0.048 0.2826 1
0.0111 0.3969 1
0.0299 0.3239 1
0.0055 0.3429 1
0.0474 0.4609 1
0.0096 0.4728 1
0.0073 0.3161 1
0.0737 0.4369 0.4632
0.0069 0.263 1
0.0774 0.3184 1
0.0099 0.3969 1
0.0095 0.3358 0.4509
0.0428 0.5137 1
0.0253 0.2666 0.2656
0.0094 0.3104 1
0.0391 0.4691 1
0.0064 0.2521 1
0.008 0.5197 1
0.0564 0.6691 1
0.0282 0.2633 0.9608
0.0253 0.2666 0.2656
0.005 0.2926 0.7822
0.0725 0.4262 0.4745
0.0681 0.5224 1
0.008 0.388 1
0.0577 0.5287 1
0.0111 0.281 1
0.0111 0.4939 1
0.009 0.3253 0.5
0.0493 0.5272 1
0.0391 0.4691 1
0.0111 0.349 0.4925
0.0286 0.3327 0.8798
0.048 0.2826 1
0.0069 1 1
0.008 0.5028 1
0.0092 0.4926 1
0.0196 0.5081 1
0.008 0.5238 1
0.008 0.3418 1
0.0111 0.3969 1
0.0102 0.5042 0.5406
0.0073 0.3161 1
0.008 0.3175 1
0.0091 0.493 0.5763
0.0076 0.2831 1
0.0076 0.6654 0.656
0.0097 0.2751 0.9711
0.0428 0.5137 1
0.008 0.352 0.6829
0.0314 0.3522 0.5
0.0077 0.4141 1
0.0362 0.441 1
0.0285 0.333 0.9073
0.008 1 0.5
0.0111 0.3969 1
0.0516 0.5585 1
0.0111 0.5009 1
0.0282 0.2633 0.9608
0.0096 0.2518 0.5388
0.0064 1 1
0.007 0.3438 0.3521
0.0365 0.391 1
0.0381 0.3642 0.3836
0.0067 0.4387 1
0.0095 0.283 0.5
0.0092 0.2704 1
0.0096 0.2505 1
0.0093 0.4685 0.4466
0.0089 0.4671 1
0.0091 0.3969 1
0.0069 0.4595 1
0.0096 0.4475 1
0.0146 0.3381 1
0.0662 0.4812 1
0.0094 0.2726 1
0.0111 0.3969 1
0.0188 0.4677 0.6049
0.0067 1 1
0.0096 0.4115 1
0.0111 0.3544 1
0.0111 0.2626 0.3573
0.0564 0.5266 1
0.0511 0.4129 1
0.0253 0.2666 0.2656
0.0111 0.3975 1
0.0576 0.5244 1
0.0665 0.4827 1
0.0664 0.5254 1
0.0111 0.4941 1
0.0096 0.3674 1
0.0292 0.5115 1
0.0069 0.281 1
0.0093 0.4988 1
0.0096 0.4846 0.461
0.0095 0.31 0.397
0.0506 0.6003 1
0.0076 0.6622 0.656
0.0066 0.3295 1
0.0089 0.3969 1
0.0094 0.2724 1
0.0095 0.4941 1
0.0466 0.3387 0.3387
0.0111 0.3053 0.9283
0.0098 0.3926 1
0.0664 0.5254 1
0.0073 0.2514 1
0.0573 0.5262 1
0.0391 0.4691 1
0.0091 0.3634 0.7289
0.0657 0.2622 1
0.0349 0.4289 1
0.0195 0.5048 1
0.0341 0.4221 1
0.0098 0.3761 0.5782
0.0676 0.5241 1
0.0067 0.2645 1
0.0089 0.3931 0.5
0.0098 0.483 1
0.0463 0.2931 0.5
0.0559 0.6707 1
0.008 0.3294 0.7926
0.0546 0.3305 0.3305
0.0078 0.2831 1
0.0632 0.501 0.501
0.0095 0.4617 1
0.008 0.3418 1
0.0077 0.3002 0.4249
0.007 0.3438 0.3521
0.0576 0.5244 1
0.0076 0.2831 1
0.0105 0.3706 1
0.0466 0.3387 0.3387
0.0111 0.2841 1
0.0666 0.5274 0.7116
0.0399 0.2554 0.2859
0.0293 0.2945 1
0.0465 0.4852 1
0.0111 0.4579 1
0.0663 0.2717 1
0.0488 0.5192 1
0.0495 0.6143 1
0.009 0.3649 0.5
0.0111 0.5009 1
0.008 1 0.5
0.0092 0.253 0.3231
0.0092 0.3567 1
0.0091 0.397 0.3745
0.009 0.3253 0.5
0.0073 1 0.5
0.0111 0.4579 1
0.0111 0.2526 1
0.0181 0.3252 1
0.0198 0.4719 1
0.046 0.2696 0.2688
0.0096 1 1
0.0616 0.3488 1
0.0096 0.7305 0.7812

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TcCLB.506885.80 (Trypanosoma cruzi), hypothetical protein
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