Detailed view for PF3D7_0106400

Basic information

TDR Targets ID: 3185
Plasmodium falciparum, pre-rRNA-processing protein TSR2, putative

Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 4.0958 | Length (AA): 156 | MW (Da): 18395 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Pfam domains

PF10273   Pre-rRNA-processing protein TSR2

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
102 144 4uf1 (A) 9 53 42.00 0.85 0.17 0.735941 -0.72

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein


Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 24 hs, Oocyst, Ring, Sporozoite, merozoite, sporozoite, early ring, early trophozoite, late ring, late trophozoite. Otto TD Zhanghi PlasmoDB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 40 hs, Female Gametocyte, gametocyte, early schizont. Otto TD Lasonder PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 32 hs, intra-erythrocytic - 48 hs, Male Gametocyte. Otto TD Lasonder
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zhanghi A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.


Ortholog group members (OG5_129326)

Species Accession Gene Product
Arabidopsis thaliana AT5G27990   pre-rRNA-processing protein TSR2, conserved region-containing protein
Brugia malayi Bm1_36460   hypothetical protein
Candida albicans CaO19.2998   similar to S. cerevisiae YLR435W
Candida albicans CaO19.10515   similar to S. cerevisiae YLR435W
Caenorhabditis elegans CELE_Y51H4A.15   Protein Y51H4A.15
Dictyostelium discoideum DDB_G0270202   hypothetical protein
Drosophila melanogaster Dmel_CG14543   CG14543 gene product from transcript CG14543-RA
Echinococcus granulosus EgrG_001083600   Pre rRNA processing protein TSR2 region
Entamoeba histolytica EHI_169830   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_001083600   Pre rRNA processing protein TSR2, region
Homo sapiens ENSG00000158526   TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
Loa Loa (eye worm) LOAG_04976   hypothetical protein
Mus musculus ENSMUSG00000025264   TSR2 20S rRNA accumulation
Neospora caninum NCLIV_051100   hypothetical protein, conserved
Oryza sativa 4345991   Os08g0508600
Onchocerca volvulus OVOC4627  
Plasmodium berghei PBANKA_0206900   pre-rRNA-processing protein TSR2, putative
Plasmodium falciparum PF3D7_0106400 this record   pre-rRNA-processing protein TSR2, putative
Plasmodium knowlesi PKNH_0207100   pre-rRNA-processing protein TSR2, putative
Plasmodium vivax PVX_081450   pre-rRNA-processing protein TSR2, putative
Plasmodium yoelii PY02262   hypothetical protein
Saccharomyces cerevisiae YLR435W   Tsr2p
Schistosoma mansoni Smp_029750   hypothetical protein
Toxoplasma gondii TGME49_237240   hypothetical protein


PF3D7_0106400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y51H4A.15 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y51H4A.15 Caenorhabditis elegans larval arrest wormbase
CELE_Y51H4A.15 Caenorhabditis elegans slow growth wormbase
PBANKA_0206900 Plasmodium berghei Essential plasmo
TGME49_237240 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site,, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model


Assay information

No assay information for this target.

Reagent availability

  • Pfal007493AAA;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Pfal007493; Recombinant protein: full-length; Source: P falciparum; hypothetical protein ;

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_0106400 (Plasmodium falciparum), pre-rRNA-processing protein TSR2, putative
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