Detailed view for TcCLB.505183.120

Basic information

TDR Targets ID: 32041
Trypanosoma cruzi, aldo/keto reductase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.0967 | Length (AA): 322 | MW (Da): 35922 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00248   Aldo/keto reductase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 320 1q5m (A) 2 317 26.00 0 1 1.15 -0.72
16 320 1frb () 2 315 27.00 0 1 1.17 -1.06
17 302 1mzr (A) 7 267 35.00 0 1 1.28 -0.74
14 302 3o0k (A) 21 278 31.00 0 1 1.20002 -0.46
14 322 1m9h (A) 2 278 25.00 0.4 1 1.15353 0.25
14 311 4otk (A) 9 275 40.00 0 1 1.32647 -0.2
21 308 1abn (A) 7 297 31.00 0 1 1.10341 0.52

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_150082)

Species Accession Gene Product
Leishmania braziliensis LbrM.26.1230   aldo/keto reductase, putative,aldo/keto reductase family-like protein
Leishmania donovani LdBPK_261190.1   aldo/keto reductase, putative
Leishmania infantum LinJ.26.1190   aldo/keto reductase, putative,aldo/keto reductase family-like protein
Leishmania major LmjF.26.1210   aldo/keto reductase, putative,aldo/keto reductase family-like protein
Leishmania mexicana LmxM.26.1210   aldo/keto reductase, putative,aldo/keto reductase family-like protein
Trypanosoma brucei gambiense Tbg972.11.6040   aldo/keto reductase, putative
Trypanosoma brucei Tb927.11.5360   aldo/keto reductase, putative
Trypanosoma congolense TcIL3000.11.5600   aldo/keto reductase, putative
Trypanosoma cruzi TcCLB.505183.120   aldo/keto reductase, putative

Essentiality

TcCLB.505183.120 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.3040 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.3040 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.3040 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.02.3040 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Aldose reductase 316 aa 26.9% 309 aa Compounds References
Bos taurus Aldose reductase 315 aa 29.3% 304 aa Compounds References
Sus scrofa Aldose reductase 316 aa 28.8% 306 aa Compounds References
Rattus norvegicus Aldose reductase-related protein 1 316 aa 29.8% 275 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0267 0.4685 0.9173
0.0291 1 1
0.0104 0.2731 0.5
0.0133 0.347 1
0.0136 0.2596 0.2194
0.0147 0.2791 0.279
0.0038 0.2659 0
0.0248 0.2657 0.2203
0.0302 0.3521 1
0.0358 1 1
0.0232 0.2744 0
0.0066 0.2599 0
0.0293 0.255 0.2531
0.0728 0.281 0.27
0.0447 0.2831 0.283
0.0792 0.2864 0.2758
0.0103 0.5227 0.5
0.0403 1 0.5
0.005 0.2563 0
0.0486 0.2879 0.0855
0.0447 0.2831 0.283
0.0323 1 1
0.0048 1 0.5
0.0128 0.5 0.5
0.003 0.2645 0
0.0486 0.2879 0.0855
0.0116 0.2503 0.2503
0.0107 0.2693 0.2601
0.0011 0.5 0.5
0.015 0.4976 0.7397
0.0210423 0.286758 0.019736
0.0028 0.5 0.5
0.0406 0.285 0
0.0265 0.2698 0
0.0244 0.2658 0.5
0.0429 0.2846 0.2846
0.028 0.2738 1
0.0066 0.2599 0
0.0704 0.2637 0
0.0719 0.2869 0.2869
0.0122 0.2815 0.2809
0.0728 0.2627 0.2854
0.0412 0.2751 0.2631
0.0723 0.2873 0.2873
0.0208 0.2751 0
0.0193 0.2745 0.2745
0.0203 0.6548 0
0.0226 0.2613 0.8964
0.0124 0.2557 0.2557
0.0325 0.8695 0.8679
0.0083 0.5859 0.7167
0.0267 0.4685 0.9173
0.000559795 0.5 0.5
0.0258 0.2864 0.2845
0.0266 0.28 0.2798
0.0283 0.3077 1
0.0358 1 1
0.0259 0.2625 0.9075
0.0248 0.2861 0.2848
0.0224 0.2774 0.2773
0.0187 0.2619 0.2479
0.0308 0.3052 1
0.0078 0.2628 0.2181
0.0162 0.2676 0.2445
0.0379 0.3762 1
0.0486 0.2879 0.0855
0.0317 0.2864 0.2858
0.0187 0.2763 0.2761
0.0249 0.2734 0.2706
0.0728 0.2627 0.2854
0.038 0.2765 0
0.0362 0.2852 0.2824
0.0215 0.3858 0.5
0.0142 0.4288 0.8317
0.0189 0.2829 0.2829
0.0241 0.2757 0.2692
0.0219 0.2804 0.2794
0.0029 0.5 0.5
0.0169 0.2516 0.2827
0.0334 0.3608 1
0.0775 0.2848 0.2846
0.0283 0.325 1
0.0123 0.2743 0.2696
0.0098 0.2938 1
0.0775 0.2848 0.2846
0.0441827 0.31328 0.312806
0.0321 0.383 1
0.0228 1 1
0.0414 0.2849 0
0.0097 0.2578 0
0.0228 0.2784 0.2783
0.0314 0.3709 1
0.0222 0.2773 0.2717
0.0356 0.2868 0.2863
0.0093 0.289 0
0.0212 0.3525 0.5
0.0011 0.5 0.5
0.0711 0.2866 0.2851
0.0142 0.4288 0.8317
0.0095 0.2694 0
0.0037 0.2705 0.2705
0.0644 0.2872 0.2871
0.0068 0.2586 0
0.0124 0.2557 0.2557
0.0188 0.2582 0.5
0.0113 1 1
0.0349 0.4052 0.9327
0.0251 0.2569 0.2796
0.0228 0.2784 0.2783
0.0419 0.2848 0.2802
0.0345 0.2767 0
0.0210423 0.286758 0.019736
0.0728 0.281 0.27
0.019 0.3172 1
0.0369 0.9928 1
0.0711 0.2866 0.2851
0.0134 0.2657 0
0.0176 0.2759 0.2741
0.0111 0.262 0.2561
0.022 0.2585 0.2547
0.0161 0.2836 0
0.0417 0.2648 0.2648
0.0277 0.9974 0.5
0.0183 0.2837 0
0.0644 0.2872 0.2871
0.0218 0.3757 1
0.0228 0.2784 0.2783
0.0137 0.2732 0.2565
0.0803 0.2819 0
0.0049 0.7607 1
0.0296 0.2862 0.2839
0.0422 0.2817 0.2802
0.0313 0.287 0.2858
0.0092 0.2686 0.2289
0.0333 0.286 0.286
0.0263 0.2656 0
0.0245 0.7634 0.7625
0.0219 0.2804 0.2794
0.0343 0.3796 1
0.0681 0.284 0.284
0.0105 0.2699 0
0.0212 0.2526 0.2707
0.021 0.2782 0.2782
0.0124 0.2557 0.2557
0.0009 1 0.5
0.0764 0.2875 0.2873
0.0086 0.2573 0
0.0047 0.254 0
0.0728 0.281 0.27
0.013 0.252 0
0.0266 0.2858 0.2858
0.0099 0.2701 0
0.0122 0.2828 0.0796
0.0188 0.3403 1
0.0249 0.2734 0.2706
0.0273 0.284 0.2519
0.076 0.2768 0.2768
0.0095 1 1
0.0349 0.4052 0.9327
0.03 0.2576 0.2576
0.0065 0.5 0.5
0.0775 0.2848 0.2846
0.0419 0.2848 0.2802
0.0248 0.2861 0.2848
0.0104 0.2511 0.2511
0.0175 0.2828 0.2828
0.0064 0.2576 0.2533
0.0143 0.2973 1
0.026 0.2829 0.285
0.0178 0.2529 0
0.0166 0.2605 0
0.0132 0.7333 1
0.0362 0.378 1
0.0404 0.2668 0.2626
0.029 0.6621 0.5
0.0141 0.2608 0.2608
0.0447 0.2831 0.283
0.0397 1 1
0.0405 0.2825 0.2825
0.0137 0.2732 0.2565
0.0728 0.281 0.27
0.0009 0.5 0.5
0.0261 0.2776 0.2743
0.0691 0.2763 0.1682
0.0327 0.3271 0.921
0.0149 0.7154 1
0.012 0.2736 0
0.0262 0.279 0.279
0.072 0.2794 0.2794
0.0289 0.3315 1
0.0803 0.2819 0
0.0075 0.2553 0
0.0222 0.3677 1
0.0099 0.2571 0.2283
0.0385 0.2793 0
0.0037 0.5707 0.5
0.0124 0.2557 0.2557
0.0287 0.252 0.284
0.015 0.2553 0
0.029 0.284 0.252
0.0689 0.2821 0.28
0.0097 0.266 0.2444
0.0278 0.284 0.284
0.0418 0.2865 0.2711
0.0259 0.8384 0.817
0.0681 0.284 0.284
0.0192 0.701 0.7985
0.0288 0.2888 1
0.0227 0.8574 1
0.0126 0.3266 0.8056
0.0279 0.2841 0.2715
0.0189 0.3641 0.5
0.0113 0.2622 0.2622
0.0644 0.2872 0.2871
0.0224 0.2838 0.2838
0.0166 0.2821 0.2744
0.0018 1 0.5
0.0277 0.2855 0.2842
0.0216 0.2688 0.2823
0.0976 0.2871 0.2866
0.0191 0.36 1
0.0349 0.4052 0.9327
0.0098 0.2533 0.2459
0.0581 0.2871 0.2866
0.0009 0.5 0.5
0.0091 0.2585 0
0.0435 0.2838 0.264
0.0268 0.2557 0.285
0.028 0.2827 0.2792
0.0098 0.2533 0.2459
0.0211 0.374 0.8022
0.0377 0.2702 0
0.0222 0.2579 0
0.0486 0.2879 0.0855
0.0284 0.2848 0.284
0.0408 0.2849 0.2848
0.0267 0.2614 0.2858
0.0313 0.3557 1
0.0161 0.2836 0
0.0369 0.9928 1
0.0199063 0.279562 0.5
0.0291 0.259 0.259
0.0124 1 0.5
0.004 0.5148 0.5
0.076 0.2768 0.2768
0.0151 1 0.5
0.0111 0.2633 0
0.0162 0.2676 0.2445
0.0059 0.2961 0.9184
0.0179 0.2537 0
0.0099 0.2571 0.2283
0.0076 0.2667 0.2667
0.0262 0.2844 1
0.0222 0.2773 0.2717
0.0219 0.778 1
0.0167 0.2773 0.2822
0.0764 0.2875 0.2873
0.0064 0.9545 0.5
0.0177 0.2579 0
0.0095 1 1
0.0764 0.2875 0.2873
0.0028 0.5 0.5
0.0269 0.2748 0
0.0295 0.3658 1
0.0242 0.2855 0.2847
0.0202 1 1
0.043 0.2876 0.2772
0.0326 0.2809 0.2699
0.0269 0.2748 0
0.0775 0.2848 0.2846
0.0301 0.3144 1
0.0342 0.365 1
0.0217 0.2779 0.2777
0.0285 0.284 0.284
0.0269 0.2546 0.26
0.0083 0.2705 0
0.0139 0.2565 0.2565
0.0157 0.2735 0.2391
0.0216 0.2638 0.285
0.0259 0.2625 0.9075
0.0108 0.2793 0
0.0011 0.5 0.5
0.0098 0.2597 0.2597

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.505183.120 (Trypanosoma cruzi), aldo/keto reductase, putative
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