Detailed view for Tb927.10.6190

Basic information

TDR Targets ID: 321724
Trypanosoma brucei, aldehyde dehydrogenase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.242 | Length (AA): 503 | MW (Da): 54034 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00171   Aldehyde dehydrogenase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016620   oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor  
GO:0016491   oxidoreductase activity  
GO:0055114   oxidation reduction  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
11 499 3ek1 (A) 0 478 43.00 0.00000011 1 1.53157 -0.94
14 499 3jz4 (A) 1 478 45.00 0.0000000074 1 1.5676 -1.06

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_127004)

Species Accession Gene Product
Arabidopsis thaliana AT1G79440   succinate-semialdehyde dehydrogenase
Brugia malayi Bm1_35520   Succinate semialdehyde dehydrogenase, mitochondrial precursor
Candida albicans CaO19.7978   putative succinate semialdehyde dehydrogenase
Candida albicans CaO19.4543   succinate-semialdehyde dehydrogenase
Candida albicans CaO19.345   putative succinate semialdehyde dehydrogenase
Candida albicans CaO19.12018   succinate-semialdehyde dehydrogenase
Caenorhabditis elegans CELE_F45H10.1   Protein ALH-7, isoform B
Drosophila melanogaster Dmel_CG34349   Unc-13 ortholog 4B (C. elegans)
Drosophila melanogaster Dmel_CG4685   Succinic semialdehyde dehydrogenase
Escherichia coli b1525   succinate semialdehyde dehydrogenase, NAD(P)+-dependent
Escherichia coli b1415   aldehyde dehydrogenase A, NAD-linked
Escherichia coli b2661   succinate-semialdehyde dehydrogenase I, NADP-dependent
Echinococcus granulosus EgrG_000329900   succinate semialdehyde dehydrogenase
Echinococcus multilocularis EmuJ_000329700   succinate semialdehyde dehydrogenase
Echinococcus multilocularis EmuJ_000329900   succinate semialdehyde dehydrogenase
Homo sapiens ENSG00000112294   aldehyde dehydrogenase 5 family, member A1
Leishmania braziliensis LbrM.35.1950   aldehyde dehydrogenase, putative
Leishmania donovani LdBPK_361840.1   aldehyde dehydrogenase, putative
Leishmania infantum LinJ.36.1840   aldehyde dehydrogenase, putative
Leishmania major LmjF.36.1760   aldehyde dehydrogenase, putative
Leishmania mexicana LmxM.36.1760   aldehyde dehydrogenase, putative
Loa Loa (eye worm) LOAG_07059   hypothetical protein
Loa Loa (eye worm) LOAG_15055   hypothetical protein
Mycobacterium leprae ML2573   PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD
Mus musculus ENSMUSG00000035936   aldhehyde dehydrogenase family 5, subfamily A1
Mycobacterium tuberculosis Rv0768   Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+])
Mycobacterium tuberculosis Rv0234c   Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1
Mycobacterium ulcerans MUL_0477   NAD-dependent aldehyde dehydrogenase AldA
Mycobacterium ulcerans MUL_1153   succinate-semialdehyde dehydrogenase
Mycobacterium ulcerans MUL_0939   NAD-dependent aldehyde dehydrogenase AldA
Neospora caninum NCLIV_068990   succinate-semialdehyde dehydrogenase, putative
Oryza sativa 9267109   Os02g0173900
Saccharomyces cerevisiae YBR006W   succinate-semialdehyde dehydrogenase (NAD(P)(+))
Schistosoma japonicum Sjp_0041240   ko:K00139 succinate-semialdehyde dehydrogenase [EC1.2.1.24], putative
Schistosoma mansoni Smp_161350   succinate semialdehyde dehydrogenase
Schmidtea mediterranea mk4.000206.03  
Schmidtea mediterranea mk4.041773.02  
Schmidtea mediterranea mk4.059086.01  
Schmidtea mediterranea mk4.000206.05   Succinate-semialdehyde dehydrogenase, mitochondrial
Trypanosoma brucei gambiense Tbg972.10.7560   aldehyde dehydrogenase, putative
Trypanosoma brucei Tb927.10.6190   aldehyde dehydrogenase, putative
Trypanosoma congolense TcIL3000_10_5250   aldehyde dehydrogenase, putative
Trypanosoma cruzi TcCLB.507641.60   aldehyde dehydrogenase, putative
Toxoplasma gondii TGME49_257480   NADP-dependent succinate-semialdehyde dehydrogenase

Essentiality

Tb927.10.6190 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu783 Mycobacterium tuberculosis non-essential nmpdr
Tb927.10.6190 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.6190 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.6190 this record Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.6190 this record Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b1415 Escherichia coli non-essential goodall
b2661 Escherichia coli non-essential goodall
CELE_F45H10.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_F45H10.1 Caenorhabditis elegans larval arrest wormbase
CELE_F45H10.1 Caenorhabditis elegans slow growth wormbase
TGME49_257480 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens aldehyde dehydrogenase 5 family, member A1 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Aldehyde dehydrogenase, cytosolic 1 501 aa 35.7% 471 aa Compounds References
Rattus norvegicus Aldehyde dehydrogenase 1A1 501 aa 35.7% 471 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Tb927.10.6190 (Trypanosoma brucei), aldehyde dehydrogenase, putative
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