Detailed view for Tb11.v5.0210

Basic information

TDR Targets ID: 321820
Trypanosoma brucei, adenosine transporter, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.6249 | Length (AA): 463 | MW (Da): 51055 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 11

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01733   Nucleoside transporter

Gene Ontology

Mouse over links to read term descriptions.
GO:1901642   GO:nucleoside transmembrane transport  

GO:0016021   integral to membrane  
GO:0016020   membrane  
GO:0005337   nucleoside transmembrane transporter activity  
GO:0006810   transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_168255)

Species Accession Gene Product
Neospora caninum NCLIV_019000   adenosine transporter, putative
Trypanosoma brucei gambiense Tbg972.5.40   adenosine transporter, putative
Trypanosoma brucei Tb11.v5.0210   adenosine transporter, putative
Toxoplasma gondii TGME49_244440   nucleoside transporter protein

Essentiality

Tb11.v5.0210 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_244440 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

Compound Source Reference
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
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ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References
ChEMBL23 References

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Trypanosoma brucei gambiense adenosine transporter, putative Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Trypanosoma brucei adenosine transporter 2 462 aa 57.6% 467 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0807 0.9696 1
0.6449 0.3811 1
0.1523 0.6588 1
0.2339 0.2536 1
0.1965 0.8114 1
0.2339 0.2642 0.3438
0.3832 0.5 0.5
0.2193 0.5399 1
0.9064 0.4044 1
0.980241 1 1
0.1889 0.5 0.5
0.2339 1 1
0.0627 0.4468 1
0.9064 0.4044 1
0.0807 0.9696 1
0.117 1 1
0.0912 0.7453 1
0.6449 0.3811 1
0.6449 0.3811 1
0.0867729 0.414624 0.554416
1.009 1 1
0.3821 1 1
0.1772 0.6358 1
0.6449 0.3811 1
0.0963 0.5983 1
0.9064 0.4044 1
0.6449 0.3811 1
0.1772 0.6358 1
0.980241 1 1
0.6449 0.3811 1
0.6449 0.3811 1
0.6669 1 1
0.1977 0.8262 1
0.2339 1 1
0.4003 1 1
0.6188 0.5 0.5
0.225 0.5 0.5
1.4687 1 1
0.1021 0.8169 1
0.2339 0.2642 0.3438
0.9064 0.4044 1
0.980241 1 1
0.2339 0.2536 1
0.454 1 0.5
0.9064 0.4044 1
0.2339 0.2536 1
0.2339 0.2642 0.3438
0.4228 1 1
0.2339 1 1
0.2339 1 1
0.0941 0.3562 1
0.6449 0.3811 1
0.6188 0.5 0.5
0.6518 1 1
0.9064 0.4044 1
0.9064 0.4044 1
0.6449 0.3811 1
0.199 0.8187 1
0.6449 0.3811 1
0.117 1 1
0.2339 0.3514 1
0.2339 0.2642 0.3438
0.0892 0.5398 0.9465
0.3987 0.5 0.5
0.2293 1 1
0.0892 0.5398 0.9465
0.6449 0.3811 1
0.9064 0.4044 1
0.5287 1 1
0.0877 0.8943 1
0.6449 0.3811 1
0.9064 0.4044 1
0.1054 0.6265 1
0.9064 0.4044 1
0.1573 0.5903 1
0.2002 0.819 1
0.9064 0.4044 1
0.6449 0.3811 1
0.1742 0.2577 1
0.4434 0.5 0.5
0.0949 0.3612 1
0.2214 0.2695 1
0.0955 0.3726 1
0.5714 0.5566 1
1.1452 0.5 0.5
0.5714 0.5566 1
0.0683 0.557 0.7661
0.6449 0.3811 1
0.6449 0.3811 1
0.4224 1 1
0.3906 1 1
0.9064 0.4044 1
0.0842 0.4814 1
0.0912 0.7453 1
0.5714 0.5566 1
0.5714 0.5566 1
0.0997 1 1
0.980241 1 1
0.225 1 1
0.1871 1 1
0.0892 0.5398 0.9465
0.0936 0.3532 1
0.2339 0.3514 1
0.2339 0.2536 1
1.048 1 1
0.2146 1 1
0.0907 1 1
0.4403 0.5 0.5
0.0915 0.3663 1
0.117 0.3909 1
0.2214 0.2695 1
0.2146 0.4994 1
0.6449 0.3811 1
1.4687 1 1
0.6449 0.3811 1
0.0887 1 1
0.2146 1 1
0.2339 0.3514 1
0.6449 0.3811 1
0.0912 0.7453 1
0.5714 1 1
0.3921 1 1
0.199 0.8187 1
0.199 0.8187 1
0.2339 1 1
0.6518 1 1
0.0683 0.557 0.7661
0.199 0.8187 1
0.0915 0.3663 1
1.0097 1 1
0.0772 0.9178 1
0.0915 0.3663 1
0.1005 1 1
0.2339 0.3514 1
0.4003 1 1
0.5714 0.5566 1
0.6449 0.3811 1
0.117 1 1
0.4369 1 1
0.454 0.6808 1
1.4687 1 1
0.9064 0.4044 1
0.2339 1 1
0.6449 0.3811 1
0.1894 1 0.5
0.1922 0.4549 0.9837
0.0867729 0.414624 0.554416
0.4129 1 1
0.0683 0.557 0.7661
0.0912 0.7453 1
0.0627 0.4468 1
0.9064 0.4044 1
0.4369 1 1
0.2293 1 1
0.4285 0.5 0.5
0.8441 1 1
1.009 1 1
0.0772 1 1
0.0946 0.3689 1
0.6449 0.3811 1
0.9064 0.4044 1
0.1772 0.6358 1
0.188 1 1
0.0946 0.3689 1

Assayability

Assay information

  • Ability to inhibit adenosine uptake by the P2 transporter in T. brucei ChEMBL
  • Ability to inhibit adenosine uptake by the P2 transporter in Trypanosoma brucei
  • Compound was tested for inhibition of Adenosine transporter P2 type by using [2-3H]-adenosine as radioligand in T. equiperdum ChEMBL
  • Compound was tested for inhibition of Adenosine transporter P2 type by using [2-3H]adenosine as radioligand in Trypanosoma equiperdum
  • Compound was tested for inhibition of Adenosine transporter P2 type by using [2-3H]-adenosine as radioligand in T. equiperdum ChEMBL
  • Compound was tested for inhibition of Adenosine transporter P2 type by using [2-3H]adenosine as radioligand in Trypanosoma equiperdum

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Tb11.v5.0210 (Trypanosoma brucei), adenosine transporter, putative
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