pI: 8.4653 |
Length (AA): 392 |
MW (Da): 43787 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 292 | 5lqf (A) | 1 | 289 | 40.00 | 0 | 1 | 1.2217 | -0.68 |
1 | 294 | 3niz (A) | 20 | 308 | 38.00 | 0 | 1 | 1.2358 | -0.72 |
2 | 295 | 4qny (A) | 19 | 315 | 34.00 | 0 | 1 | 1.1778 | -0.89 |
4 | 318 | 1j1b (A) | 56 | 371 | 35.00 | 0 | 1 | 1.23137 | -0.64 |
4 | 342 | 4l44 (A) | 68 | 382 | 28.00 | 0 | 1 | 1.0006 | 0.08 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127559)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G45430 | protein kinase superfamily protein |
Arabidopsis thaliana | AT4G19110 | conserved peptide upstream open reading frame 25 |
Candida albicans | CaO19.9931 | serine/threonine kinase, positive regulator of meiosis |
Candida albicans | CaO19.2395 | serine/threonine kinase, positive regulator of meiosis |
Caenorhabditis elegans | CELE_M04C9.5 | Protein DYF-5, isoform B |
Dictyostelium discoideum | DDB_G0268078 | RCK family protein kinase |
Drosophila melanogaster | Dmel_CG42366 | CG42366 gene product from transcript CG42366-RA |
Echinococcus granulosus | EgrG_000591900 | serine:threonine protein kinase MAK |
Echinococcus multilocularis | EmuJ_000591900 | serine:threonine protein kinase MAK |
Giardia lamblia | GL50803_6700 | Kinase, CMGC RCK |
Homo sapiens | ENSG00000111837 | male germ cell-associated kinase |
Homo sapiens | ENSG00000112144 | intestinal cell (MAK-like) kinase |
Leishmania braziliensis | LbrM.27.0110 | protein kinase, putative |
Leishmania braziliensis | LbrM.19.0490 | mitogen activated protein kinase, putative,map kinase, putative |
Leishmania donovani | LdBPK_270100.1 | protein kinase, putative |
Leishmania donovani | LdBPK_190170.1 | mitogen-activated protein kinase 9, putative |
Leishmania infantum | LinJ.19.0170 | mitogen activated protein kinase, putative,map kinase, putative |
Leishmania infantum | LinJ.27.0100 | protein kinase, putative |
Leishmania major | LmjF.27.0100 | protein kinase, putative |
Leishmania major | LmjF.19.0180 | mitogen activated protein kinase, putative,map kinase, putative |
Leishmania mexicana | LmxM.19.0180 | mitogen activated protein kinase, putative,map kinase, putative |
Leishmania mexicana | LmxM.27.0100 | protein kinase, putative |
Loa Loa (eye worm) | LOAG_06734 | hypothetical protein |
Loa Loa (eye worm) | LOAG_12455 | CMGC/RCK/MAK protein kinase |
Mus musculus | ENSMUSG00000009828 | intestinal cell kinase |
Mus musculus | ENSMUSG00000021363 | male germ cell-associated kinase |
Oryza sativa | 4330434 | Os02g0700600 |
Oryza sativa | 4339927 | Os06g0116100 |
Saccharomyces cerevisiae | YJL106W | Ime2p |
Schistosoma japonicum | Sjp_0307390 | ko:K03127 transcription initiation factor TFIID subunit D11, putative |
Schistosoma japonicum | Sjp_0065020 | Oxysterol-binding protein-related protein 9, putative |
Schistosoma japonicum | Sjp_0098600 | IPR000719,Protein kinase;IPR006163,Phosphopantetheine-binding;IPR011009,Protein kinase-like,domain-containing |
Schistosoma mansoni | Smp_132890 | serine/threonine protein kinase |
Schmidtea mediterranea | mk4.002465.00 | |
Schmidtea mediterranea | mk4.001636.02 | |
Trypanosoma brucei gambiense | Tbg972.10.17970 | protein kinase, putative |
Trypanosoma brucei gambiense | Tbg972.3.300 | protein kinase, putative |
Trypanosoma brucei | Tb927.3.690 | CMGC/RCK protein kinase, putative |
Trypanosoma brucei | Tb927.10.14800 | mitogen-activated protein kinase 9, putative |
Trypanosoma congolense | TcIL3000_10_12670 | mitogen-activated protein kinase 9, putative |
Trypanosoma cruzi | TcCLB.509719.50 | CMGC/RCK protein kinase, putative |
Trypanosoma cruzi | TcCLB.506211.180 | mitogen-activated protein kinase 9, putative |
Trypanosoma cruzi | TcCLB.509231.20 | CMGC/RCK protein kinase, putative |
Trypanosoma cruzi | TcCLB.511289.50 | mitogen-activated protein kinase 9, putative |
Trichomonas vaginalis | TVAG_129430 | CMGC family protein kinase |
Trichomonas vaginalis | TVAG_529130 | CMGC family protein kinase |
Trichomonas vaginalis | TVAG_399660 | CMGC family protein kinase |
Trichomonas vaginalis | TVAG_583940 | CMGC family protein kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.3.690 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.690 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.690 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.3.690 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.10.14800 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.14800 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.14800 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.14800 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.5
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | male germ cell-associated kinase | Compounds | References |
Homo sapiens | intestinal cell (MAK-like) kinase | Compounds | References |