TDR Targets

Detailed view for PF3D7_0113800

Basic information

TDR Targets ID: 3252
Plasmodium falciparum, DBL containing protein, unknown function
Source Database / ID: PlasmoDB | GeneDB | MPMP

pI: 5.0901 | Length (AA): 2900 | MW (Da): 346566 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Network

Pfam domains

PF05424 Duffy binding domain

Gene Ontology

Mouse over links to read term descriptions.

GO:0046789 host cell surface receptor binding
GO:0016021 integral to membrane
GO:0004872 receptor activity
GO:0009405 pathogenesis

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 28 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg	Target End	Template	Template Beg	Template End	Identity	Evalue	Model Score	MPQS	zDope
654	1335	1zro (A)	15	600	26.00	0	1	0.23	0.89
340	534	4uos (A)	2	184	19.00	0.5	0.48	0.315241	-1.26
556	1237	2yk0 (A)	19	715	14.00	0	0.86	0.149172	1.06
622	1316	4p1t (A)	1218	1904	24.00	0	1	0.150655	1.03
649	945	3rrc (A)	215	507	22.00	0.0000000000055	1	0.288414	-0.42
658	943	4nuu (A)	213	505	23.00	0	1	0.385421	-0.68
797	907	4v3e (A)	532	644	33.00	0.4	0.09	0.122376	0.25
949	1568	2yk0 (A)	27	713	20.00	0	1	0.162593	0.9
1009	1311	2y8d (A)	2331	2597	37.00	0	1	0.335583	-0.11
1036	1334	4nuu (A)	210	508	23.00	0.000000000011	1	0.347103	-0.5
1047	1383	2yk0 (A)	117	513	31.00	0	1	0.231307	0.25
1945	2162	1yo8 (A)	717	961	32.00	0.00000021	0.12	0.0862724	0.01
2024	2159	1ux6 (A)	816	938	30.00	0.029	0.07	0.265997	-1.12
2555	2744	4uos (A)	1	183	22.00	0.0014	0.29	0.399317	-1.46
2572	2757	4tql (A)	18	201	25.00	0.47	0.57	0.332238	-0.61
3	570	3s5h (A)	348	997	19.00	0.00055	0.74	-0.0271128	1.7
275	457	4uos (A)	2	185	20.00	0.22	0.56	0.268993	-0.86
622	1329	4p1t (A)	1218	1915	24.00	0	1	0.155849	1.11
655	945	4nuu (A)	210	505	22.00	0	1	0.341892	-0.49
797	935	4v3e (A)	532	672	30.00	0.33	0.06	0.158619	0.15
958	1592	2yk0 (A)	34	712	19.00	0	1	0.22274	0.78
990	1335	2xu0 (A)	27	469	27.00	0	1	0.255734	-0.04
1033	1318	3vuu (A)	162	454	35.00	0	1	0.281979	0.66
1045	1344	2wau (A)	2350	2634	28.00	0	1	0.357975	-0.22
1966	2100	1ux6 (A)	820	958	27.00	0.024	0.01	0.376249	-1.09
1996	2265	1yo8 (A)	725	968	28.00	0.0000003	0.02	0.143497	0.51
2560	2752	4uos (A)	1	183	22.00	0.00047	0.14	0.336319	-1.23
2577	2776	4tql (A)	18	201	25.00	0.38	0.69	0.264517	-0.37

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

1ZRL:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

1ZRO:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

2WAU:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

2XU0:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

2Y8D:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

2YK0:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

3BQI:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

3BQK:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

3BQL:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

3CML:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

3CPZ:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

3VUU:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

3VUV:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

4GF2:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

4JNO:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

4P1T:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

4QEX:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

5MZA:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

Expression

Upregulation Percent	Ranking	Stage	Dataset
Upper 80-100% percentile		Sporozoite.	Zanghi G

Upregulation Percent	Ranking	Stage	Dataset
Mid 40-60% percentile		intra-erythrocytic - 16 hs, Ring.	Otto TD Zanghi G

Upregulation Percent	Ranking	Stage	Dataset
Lower 20-40% percentile		intra-erythrocytic - 8 hs.	Otto TD

Upregulation Percent	Ranking	Stage	Dataset
Lower 0-20% percentile		intra-erythrocytic - 0 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst, Female Gametocyte, Male Gametocyte.	Otto TD Zanghi G Lasonder E

Show/Hide expression data references

Zanghi G

A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Otto TD

New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Lasonder E

Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_197688)

Species	Accession	Gene Product
Plasmodium falciparum	PF3D7_0113800	DBL containing protein, unknown function

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets

Non orthologous druggable targets

By sequence similarity to non orthologous druggable targets

No additional associated druggable targets

Obtained from network model

No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier	PF3D7_0113800 (Plasmodium falciparum), DBL containing protein, unknown function

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