Detailed view for TcCLB.509237.10

Basic information

TDR Targets ID: 33525
Trypanosoma cruzi, mevalonate kinase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.6771 | Length (AA): 328 | MW (Da): 35274 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00288   GHMP kinases N terminal domain
PF08544   GHMP kinases C terminal

Gene Ontology

Mouse over links to read term descriptions.
GO:0005737   cytoplasm  
GO:0016301   kinase activity  
GO:0005524   ATP binding  
GO:0004496   mevalonate kinase activity  
GO:0016310   phosphorylation  
GO:0008299   isoprenoid biosynthetic process  
GO:0008152   metabolic process  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 328 1pie (A) 18 396 24.00 0 1 1.11 -0.02
6 323 1kkh (A) 1 317 21.00 0 1 1.18 -0.36
242 292 2a2c (A) 360 411 43.00 0.0000014 0.56 0.71 -0.86
1 326 2hfs (A) 1 326 59.00 0 1 1.7857 -1.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128331)

Species Accession Gene Product
Arabidopsis thaliana AT5G27450   mevalonate kinase
Brugia malayi Bm1_46240   mevalonate kinase family protein
Candida albicans CaO19.4809   Mevalonate kinase
Candida albicans CaO19.12272   Mevalonate kinase
Caenorhabditis elegans CELE_Y42G9A.4   Protein MVK-1, isoform C
Dictyostelium discoideum DDB_G0272018   mevalonate kinase
Drosophila melanogaster Dmel_CG33671   CG33671 gene product from transcript CG33671-RA
Echinococcus granulosus EgrG_000762200   Mevalonate galactokinase
Echinococcus multilocularis EmuJ_000762200   Mevalonate galactokinase
Giardia lamblia GL50803_4964   Mevalonate kinase
Homo sapiens ENSG00000110921   mevalonate kinase
Leishmania braziliensis LbrM.31.0720   mevalonate kinase, putative
Leishmania donovani LdBPK_310580.1   mevalonate kinase, putative
Leishmania infantum LinJ.31.0580   mevalonate kinase, putative
Leishmania major LmjF.31.0560   mevalonate kinase, putative
Leishmania mexicana LmxM.30.0560   mevalonate kinase, putative
Loa Loa (eye worm) LOAG_09499   hypothetical protein
Loa Loa (eye worm) LOAG_12880   hypothetical protein
Mus musculus ENSMUSG00000041939   mevalonate kinase
Mycobacterium ulcerans MUL_3525   mevalonate kinase, Erg12
Oryza sativa 4348331   Os10g0329300
Saccharomyces cerevisiae YMR208W   mevalonate kinase
Schistosoma japonicum Sjp_0034900   ko:K00869 mevalonate kinase [EC2.7.1.36], putative
Schistosoma mansoni Smp_042980   mevalonate kinase
Schmidtea mediterranea mk4.008068.04  
Schmidtea mediterranea mk4.020197.02   Mevalonate kinase
Schmidtea mediterranea mk4.000404.01   Mevalonate kinase
Trypanosoma brucei gambiense Tbg972.4.4200   mevalonate kinase, putative
Trypanosoma brucei Tb927.4.4070   mevalonate kinase, putative
Trypanosoma congolense TcIL3000_10_13910   mevalonate kinase, putative
Trypanosoma cruzi TcCLB.509237.10   mevalonate kinase, putative
Trichomonas vaginalis TVAG_424580   mevalonate kinase, putative

Essentiality

TcCLB.509237.10 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.4070 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.4070 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.4070 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.4070 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y42G9A.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y42G9A.4 Caenorhabditis elegans larval arrest wormbase
YMR208W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0276 0.4475 0.4439
0.0166 0.282 0.282
0.0304 0.4487 0.4424
0.0071 0.2561 0.2539
0.03 0.2897 0.3578
0.0271 0.4433 0.4338
0.0131 0.2943 0.3741
0.0166 0.2553 0.2553
0.007 0.2569 0.2548
0.0327 0.339 0.4463
0.0073 0.2562 0.254
0.0077 0.2602 0.257
0.0305 0.4063 0.3545
0.0275 0.3195 0.3733
0.0196 0.2839 0.2814
0.0343 0.4478 0.4462
0.0139 0.3138 0.366
0.0182 0.2837 0.2837
0.0327 0.339 0.4463
0.0121 0.279 0.2779
0.0124 0.2869 0.2803
0.025 0.4306 0.4339
0.0369 0.3782 0.4407
0.0107 0.342 0.2416
0.0089 0.3273 0.3273
0.0196 0.2839 0.2814
0.0178 0.2636 0.2636
0.0107 0.342 0.2416
0.0322 0.3643 0.3643
0.0328 0.3837 0.4463
0.0353 0.4499 0.4472
0.0171 0.2958 0.2759
0.0352 0.4435 0.44
0.0343 0.4235 0.444
0.0108 0.3418 0.3293
0.0088 0.3513 0.2517
0.0352 0.4469 0.4468
0.0113 0.3445 0.3344
0.03 0.2897 0.3578
0.0329 0.4445 0.4393

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.509237.10 (Trypanosoma cruzi), mevalonate kinase, putative
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