Detailed view for TcCLB.504017.10

Basic information

TDR Targets ID: 33769
Trypanosoma cruzi, transcription factor btf3, putative

Source Database / ID:  TriTrypDB  GeneDB

pI: 9.4334 | Length (AA): 131 | MW (Da): 15099 | Paralog Number: 1

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01849   NAC domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
35 89 2ahm (E) 60 114 22.00 0.47 0.2 0.755647 -1.02
80 130 3mcb (B) 53 103 31.00 0 0.69 0.789113 -0.27

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_127333)

Species Accession Gene Product
Arabidopsis thaliana AT1G17880   basic transcription factor 3
Arabidopsis thaliana AT1G73230   nascent polypeptide-associated complex subunit beta
Babesia bovis BBOV_III010510   NAC domain containing protein
Brugia malayi Bm1_43925   beta-NAC-like protein
Candida albicans CaO19.8746   similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp
Candida albicans CaO19.1154   similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp
Caenorhabditis elegans CELE_C56C10.8   Protein ICD-1
Cryptosporidium hominis Chro.60282   NAC domain protein
Cryptosporidium parvum cgd6_2430   BTF domain, basal transcription factor
Dictyostelium discoideum DDB_G0281795   nascent polypeptide-associated complex NAC domain-containing protein
Drosophila melanogaster Dmel_CG3644   bicaudal
Echinococcus granulosus EgrG_000176200   transcription factor btf3
Entamoeba histolytica EHI_198870   transcription factor BTF3, putative
Entamoeba histolytica EHI_048560   hypothetical protein
Echinococcus multilocularis EmuJ_000176200   transcription factor btf3
Homo sapiens ENSG00000134717   basic transcription factor 3-like 4
Homo sapiens ENSG00000145741   basic transcription factor 3
Leishmania braziliensis LbrM.35.4010   basic transcription factor 3a, putative
Leishmania donovani LdBPK_363960.1   transcription factor btf3, putative
Leishmania infantum LinJ.36.3960   basic transcription factor 3a, putative
Leishmania major LmjF.36.3770   basic transcription factor 3a, putative
Leishmania mexicana LmxM.36.3770   basic transcription factor 3a, putative
Loa Loa (eye worm) LOAG_03020   ICD-1 protein
Mus musculus 100048185   predicted gene, 29692
Mus musculus ENSMUSG00000028568   basic transcription factor 3-like 4
Mus musculus 101055993   predicted gene 29138
Mus musculus ENSMUSG00000021660   basic transcription factor 3
Neospora caninum NCLIV_029860   hypothetical protein
Oryza sativa 4331347   Os03g0109600
Oryza sativa 4348929   Os10g0483000
Oryza sativa 4334799   Os03g0851000
Plasmodium berghei PBANKA_1018500   transcription factor 3b, putative
Plasmodium falciparum PF3D7_1426100   basic transcription factor 3b, putative
Plasmodium knowlesi PKNH_1332600   basic transcription factor 3b, putative
Plasmodium vivax PVX_085220   basic transcription factor 3b, putative
Plasmodium yoelii PY05141   basic transcription factor 3, putative
Saccharomyces cerevisiae YPL037C   Egd1p
Schistosoma japonicum Sjp_0102880   ko:K01527 nascent polypeptide-associated complex subunit beta, putative
Schistosoma mansoni Smp_002180.2   transcription factor btf3
Schmidtea mediterranea mk4.000346.03   Transcription factor BTF3 homolog
Schmidtea mediterranea mk4.000504.07   Transcription factor BTF3 homolog
Trypanosoma brucei gambiense Tbg972.11.10890   nascent polypeptide associated complex alpha subunit, putative
Trypanosoma brucei Tb927.11.9700   transcription factor BTF3, putative
Trypanosoma cruzi TcCLB.504017.10   transcription factor btf3, putative
Trypanosoma cruzi TcCLB.511231.80   transcription factor btf3, putative
Toxoplasma gondii TGME49_257090   NAC domain-containing protein
Theileria parva TP02_0090   transcription factor BTF3, putative
Trichomonas vaginalis TVAG_072140   conserved hypothetical protein
Trichomonas vaginalis TVAG_265540   conserved hypothetical protein
Trichomonas vaginalis TVAG_435990   conserved hypothetical protein

Essentiality

TcCLB.504017.10 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.1465 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.1465 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.1465 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.1465 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C56C10.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_C56C10.8 Caenorhabditis elegans slow growth wormbase
CELE_C56C10.8 Caenorhabditis elegans sterile wormbase
PBANKA_1018500 Plasmodium berghei Essential plasmo
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Streptococcus pyogenes Streptokinase Compounds References
Streptococcus pyogenes serotype M1 Streptokinase A Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0303 0.3263 0.9089
0.0035 0.5431 0.5
0.0042 1 1
0.0036 0.6342 1
0.0215 0.3052 1
0.0158 0.5363 0.5
0.0042 0.3017 0.8912
0.0042 0.447 1
0.0039 1 0.5
0.0042 0.2652 0.5
0.0041 0.255 0.5
0.0225 0.2839 1
0.0042 0.397 1
0.0034 0.5431 0.5
0.0215 0.3052 1
0.0121 0.3077 1
0.007 0.2512 1
0.0322 0.302 1
0.0034 0.5464 0.5
0.026 0.3738 0.6907
0.0041 1 1
0.0225 0.2977 1
0.0042 0.548 0.5
0.0187 0.3433 1
0.0034 0.5431 0.5
0.0262 0.277 1
0.0042 0.6342 1
0.0229 0.2935 1
0.0261 0.2613 0.7767
0.0159 1 0.5
0.0042 1 1
0.0042 0.2583 1
0.0036 0.6043 1
0.0187 0.3433 1
0.0074 0.2627 1
0.0042 0.3627 1
0.0135 0.5 0.5
0.014 0.3338 1
0.0042 1 1
0.0042 1 0.5
0.0042 0.4191 0.4089
0.0325 0.2626 1
0.0296 0.3104 0.8843
0.0042 0.6174 1
0.0078 0.6231 0.605
0.0042 0.4669 0.5
0.0039 0.3528 0.5
0.0036 0.3637 0.5
0.0039 0.3349 1
0.0034 0.5431 0.5
0.0042 0.9529 0.5
0.0331 0.2614 0.5755
0.0157 0.5249 1
0.0042 0.447 1
0.0201 0.3184 1
0.0322 0.2618 1
0.0055 0.38 1
0.0042 0.255 0.5
0.0201 0.5638 1
0.0042 0.2841 1
0.011 0.3813 1
0.0079 0.2945 1
0.0034 0.5431 0.5
0.0042 0.548 0.5
0.0042 0.6149 0.6149
0.0042 1 1
0.0223 0.4397 1
0.0034 1 1
0.0041 0.9423 1
0.0039 0.4334 0.3698
0.0042 0.3535 0.0698
0.0072 0.3437 0.4071
0.0357 0.2903 1
0.0034 0.3842 1
0.0065 0.38 1
0.0161 1 1
0.0155 0.2547 1
0.0149 0.2831 1
0.0042 0.687 1
0.0034 0.3842 1
0.0042 0.3388 1
0.0042 0.2555 1
0.0296 0.2704 1
0.0042 0.5 0.5
0.0137 0.2666 1
0.0294 0.3208 0.9206
0.0253 0.2775 0.7876
0.0076 0.2783 1
0.0042 0.2647 0.6147
0.0072 0.3499 0.422
0.0042 1 1
0.022 0.2818 1
0.0042 0.3017 0.5
0.0139 0.2501 1
0.0069 0.4288 1
0.007 0.263 1
0.0041 0.3959 1
0.0075 0.288 1
0.0069 0.3105 0.5
0.0042 0.3627 1
0.0201 0.5638 1
0.0042 0.4224 0.5
0.007 0.4319 0.5
0.0256 0.2542 1
0.0042 0.5251 1
0.0109 0.5 0.5
0.0108 0.4693 1
0.0262 0.277 1
0.0042 0.5958 0.5
0.0042 1 1
0.0042 1 1
0.008 0.3954 1
0.0076 0.2619 0.5
0.0201 0.3184 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.504017.10 (Trypanosoma cruzi), transcription factor btf3, putative
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