pI: 7.1198 |
Length (AA): 562 |
MW (Da): 64476 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 560 | 1t1u (A) | 65 | 615 | 31.00 | 0 | 1 | 1.31 | -1.08 |
5 | 560 | 1nm8 (A) | 59 | 598 | 33.00 | 0 | 1 | 1.42 | -1.13 |
3 | 561 | 1nm8 (A) | 57 | 599 | 33.00 | 0 | 1 | 1.37206 | -0.56 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | metacyclic. | Smircich P |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | epimastigote. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_129191)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_02015 | Choline/Carnitine o-acyltransferase family protein |
Caenorhabditis elegans | CELE_Y46G5A.17 | Protein CPT-1 |
Drosophila melanogaster | Dmel_CG12891 | withered |
Echinococcus granulosus | EgrG_000721500 | carnitine O palmitoyltransferase 1 liver |
Echinococcus multilocularis | EmuJ_000721500 | carnitine O palmitoyltransferase 1, liver |
Homo sapiens | ENSG00000205560 | carnitine palmitoyltransferase 1B (muscle) |
Homo sapiens | ENSG00000169169 | carnitine palmitoyltransferase 1C |
Homo sapiens | ENSG00000110090 | carnitine palmitoyltransferase 1A (liver) |
Leishmania braziliensis | LbrM.19.1800 | choline/Carnitine o-acyltransferase-like protein |
Leishmania donovani | LdBPK_191570.1 | choline/Carnitine o-acyltransferase-like protein |
Leishmania infantum | LinJ.19.1570 | choline/Carnitine o-acyltransferase-like protein |
Leishmania major | LmjF.19.1540 | choline/Carnitine o-acyltransferase-like protein |
Leishmania mexicana | LmxM.19.1540 | choline/Carnitine o-acyltransferase-like protein |
Loa Loa (eye worm) | LOAG_06041 | hypothetical protein |
Mus musculus | ENSMUSG00000024900 | carnitine palmitoyltransferase 1a, liver |
Mus musculus | ENSMUSG00000078937 | carnitine palmitoyltransferase 1b, muscle |
Mus musculus | ENSMUSG00000007783 | carnitine palmitoyltransferase 1c |
Schmidtea mediterranea | mk4.020197.01 | |
Schmidtea mediterranea | mk4.004183.01 | Peroxisomal carnitine O-octanoyltransferase |
Schmidtea mediterranea | mk4.003010.04 | |
Schmidtea mediterranea | mk4.020197.00 | LD31742p |
Schmidtea mediterranea | mk4.000720.06 | |
Schmidtea mediterranea | mk4.001768.02 | |
Schmidtea mediterranea | mk4.001768.00 | |
Schmidtea mediterranea | mk4.003010.03 | |
Schmidtea mediterranea | mk4.016069.00 | |
Schmidtea mediterranea | mk4.003010.05 | |
Schmidtea mediterranea | mk4.003010.01 | LD31742p |
Schmidtea mediterranea | mk4.001768.03 | |
Schmidtea mediterranea | mk4.055407.00 | |
Schmidtea mediterranea | mk4.007161.00 | |
Schmidtea mediterranea | mk4.014696.01 | |
Schmidtea mediterranea | mk4.000720.07 | |
Trypanosoma cruzi | TcCLB.507211.10 | choline/carnitine O-acyltransferase, putative |
Trypanosoma cruzi | TcCLB.511353.4 | choline/carnitine O-acyltransferase, putative |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.6
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Rattus norvegicus | Carnitine palmitoyltransferase 1A | Compounds | References |
Sus scrofa | Carnitine palmitoyltransferase 1A | Compounds | References |
Rattus norvegicus | Carnitine palmitoyltransferase 1B | Compounds | References |
Homo sapiens | carnitine palmitoyltransferase 1B (muscle) | Compounds | References |
Homo sapiens | carnitine palmitoyltransferase 1A (liver) | Compounds | References |