pI: 8.321 |
Length (AA): 547 |
MW (Da): 59496 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 10 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
39 | 533 | 2acx (A) | 14 | 532 | 19.00 | 0 | 1 | 0.92 | 0.62 |
218 | 474 | 2clq (A) | 683 | 938 | 44.00 | 0 | 1 | 0.99 | -0.83 |
98 | 474 | 1ym7 (A) | 70 | 453 | 22.00 | 0 | 1 | 0.873014 | 0.26 |
176 | 506 | 4wih (A) | 3 | 350 | 29.00 | 0 | 1 | 0.876519 | -0.23 |
205 | 545 | 3lij (A) | 52 | 381 | 30.00 | 0 | 1 | 0.9198 | -0.08 |
211 | 475 | 4bf2 (A) | 671 | 939 | 41.00 | 0 | 1 | 0.859861 | -0.37 |
214 | 476 | 2rku (A) | 52 | 307 | 29.00 | 0 | 1 | 0.847204 | -0.38 |
214 | 516 | 3qkl (A) | 149 | 471 | 28.00 | 0 | 1 | 0.872331 | -0.3 |
214 | 529 | 5es1 (A) | 55 | 360 | 32.00 | 0 | 1 | 0.899097 | -0.13 |
298 | 473 | 5cem (A) | 165 | 337 | 29.00 | 0.00000057 | 0.99 | 0.646355 | -0.73 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_130258)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_16860 | Neuronal symmetry protein 1 |
Drosophila melanogaster | Dmel_CG4720 | Protein kinase at 92B |
Echinococcus granulosus | EgrG_000469200 | mitogen activated protein kinase kinase kinase |
Echinococcus multilocularis | EmuJ_000469200 | mitogen activated protein kinase kinase kinase |
Homo sapiens | ENSG00000197442 | mitogen-activated protein kinase kinase kinase 5 |
Homo sapiens | ENSG00000180815 | mitogen-activated protein kinase kinase kinase 15 |
Homo sapiens | ENSG00000142733 | mitogen-activated protein kinase kinase kinase 6 |
Loa Loa (eye worm) | LOAG_07660 | STE/STE11/ASK protein kinase |
Loa Loa (eye worm) | LOAG_10715 | hypothetical protein |
Loa Loa (eye worm) | LOAG_11550 | hypothetical protein |
Mus musculus | ENSMUSG00000031303 | mitogen-activated protein kinase kinase kinase 15 |
Mus musculus | ENSMUSG00000028862 | mitogen-activated protein kinase kinase kinase 6 |
Mus musculus | ENSMUSG00000071369 | mitogen-activated protein kinase kinase kinase 5 |
Schistosoma japonicum | Sjp_0311890 | Mitogen-activated protein kinase kinase kinase 15, putative |
Schistosoma japonicum | Sjp_0098560 | IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing |
Schistosoma japonicum | Sjp_0112540 | ko:K04426 mitogen-activated protein kinase kinase kinase 5, putative |
Schistosoma japonicum | Sjp_0314880 | IPR010993,Sterile alpha motif homology,domain-containing |
Schistosoma japonicum | Sjp_0069170 | Mitogen-activated protein kinase kinase kinase 15, putative |
Schistosoma japonicum | Sjp_0112550 | expressed protein |
Schistosoma japonicum | Sjp_0133840 | IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing |
Schistosoma mansoni | Smp_162800.2 | protein kinase |
Schistosoma mansoni | Smp_162800.1 | protein kinase |
Schmidtea mediterranea | mk4.002610.03 | |
Schmidtea mediterranea | mk4.010145.00 | |
Schmidtea mediterranea | mk4.006075.05 | |
Schmidtea mediterranea | mk4.001906.00 | |
Schmidtea mediterranea | mk4.005023.02 | |
Schmidtea mediterranea | mk4.011946.00 | |
Schmidtea mediterranea | mk4.015163.00 | Serine/threonine-protein kinase flr-4 |
Schmidtea mediterranea | mk4.005023.04 | Mitogen-activated protein kinase kinase kinase 6 |
Schmidtea mediterranea | mk4.000175.10 | |
Trypanosoma cruzi | TcCLB.509937.130 | STE/STE11 serine/threonine-protein kinase, putative |
Trypanosoma cruzi | TcCLB.510409.10 | STE/STE11 serine/threonine-protein kinase, putative |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.7
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase kinase kinase 15 | Compounds | References |
Homo sapiens | mitogen-activated protein kinase kinase kinase 6 | Compounds | References |
Homo sapiens | mitogen-activated protein kinase kinase kinase 5 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 29.2% | 295 aa | Compounds | References |
Rattus norvegicus | Jak1 protein | 210 aa | 26.8% | 198 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 30.1% | 276 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 30.0% | 280 aa | Compounds | References |
Rattus norvegicus | Serine/threonine-protein kinase pim-3 | 326 aa | 25.6% | 289 aa | Compounds | References |
Zea mays | Casein kinase II alpha | 332 aa | 22.7% | 304 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 31.3% | 281 aa | Compounds | References |