Detailed view for TcCLB.511235.20

Basic information

TDR Targets ID: 34845
Trypanosoma cruzi, glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 10.5495 | Length (AA): 214 | MW (Da): 22646 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02800   Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016620   oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor  
GO:0051287   NAD binding  
GO:0055114   oxidation reduction  
GO:0006006   glucose metabolic process  

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 214 1gga (O) 132 352 42.00 0 1 1.5 -0.32
1 213 1gad (O) 118 330 59.00 0 1 1.69 -0.63
1 214 5c7i (O) 223 438 50.00 0 1 1.6342 -0.45
1 214 3sth (A) 120 337 50.00 0 1 1.6148 -0.31
1 213 4lsm (A) 125 337 70.00 0 1 1.83013 -0.41

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 4LSM:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_185316)

Species Accession Gene Product
Trypanosoma cruzi TcCLB.503723.90   glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative
Trypanosoma cruzi TcCLB.511235.20   glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative
Trypanosoma cruzi TcCLB.506409.240   glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0088 0.2674 0
0.0653 0.2667 0.262
0.0519 0.2599 0.2599
0.0731 0.2757 0
0.0091 0.2675 0.2646
0.0691 0.2693 0.2664
0.0593 0.2556 0.253
0.0614 0.2558 0.2558
0.0706 0.3099 0.3094
0.0691 0.2693 0.2664
0.0614 0.2558 0.2558
0.0691 0.2693 0.2664
0.0533 0.2524 0.2524
0.0691 0.2693 0.2664
0.0087 0.2709 0.2709
0.0614 0.2873 0.2871
0.0533 0.2634 0
0.0689 0.2624 0.2624
0.0686 0.2689 0.2685
0.0691 0.2693 0.2664
0.009 0.2842 0
0.0691 0.2693 0.2664
0.0614 0.2558 0.2558
0.0731 0.2757 0
0.07 0.2748 0.2748

Assayability

Assay information

  • Assay for Glyceraldehyde-3-Phosphate Dehydrogenase from Bacillus (1.2.1.12 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

  • Reagent:
  • Target Type Source Notes
    TcCLB.511235.20 cloned gene BRENDA A gene with this EC number or name or sequence has been cloned from Trypanosoma cruzi ( 1 )

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.511235.20 (Trypanosoma cruzi), glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative
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