Detailed view for PF3D7_0304600

Basic information

TDR Targets ID: 3547
Plasmodium falciparum, circumsporozoite (CS) protein
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 5.1768 | Length (AA): 397 | MW (Da): 42646 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: Y | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00090   Thrombospondin type 1 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0009986   cell surface  

Metabolic Pathways

Malaria (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
67 121 2n26 (A) 58 112 9.00 0.008 0 0.460539 -2.65
306 374 3vdj (A) 306 374 94.00 0.000000005 1 1.3758 -1.95
145 307 4kgq (C) 34 196 9.00 0.4 0 0.680461 -2.36
323 388 3vdj (A) 310 375 89.00 0.000000035 1 1.32688 -2.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 3VDJ:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3VDK:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3VDL:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile gametocyte, merozoite, sporozoite, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Sporozoite. PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, early ring. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 16 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Ring, Female Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, Male Gametocyte. Otto TD Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 8 hs. Otto TD
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_159725)

Species Accession Gene Product
Oryza sativa 4334365   Os03g0788400
Plasmodium berghei PBANKA_0403200   circumsporozoite (CS) protein
Plasmodium falciparum PF3D7_0304600   circumsporozoite (CS) protein
Plasmodium knowlesi PKNH_0838500   circumsporozoite (CS) protein
Plasmodium vivax PVX_187290   unspecified product
Plasmodium vivax PVX_119355   circumsporozoite (CS) protein
Plasmodium yoelii PY03168   circumsporozoite protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium berghei 81384   324802   576750  
Annotator: saralph@unimelb.edu.au. Comment: 012/Mar/09. References: 15630135 16641443
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium yoelii yoelii 81384   324802   576750  
Annotator: saralph@unimelb.edu.au. Comment: 012/Mar/09. References: 15630135 16641443

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

Compound Source Reference
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0324 0.3378 0.6121
0.036 0.3475 0.8022
0.0344 0.3364 0.656
0.036 0.3274 1
0.0324 0.3378 0.6121
0.036 0.3475 0.8022
0.0309 0.3187 0.6909
0.0293 0.3231 0.6874
0.0324 0.3378 0.6121
0.0297 0.329 0.5872
0.0324 0.4224 1
0.036 0.3475 0.8022
0.0297 0.329 0.5872
0.0317 0.31 0.7183

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

2 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0304600 (Plasmodium falciparum), circumsporozoite (CS) protein
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