Detailed view for BBOV_II000610

Basic information

TDR Targets ID: 358520
Babesia bovis, asparagine rich protein, putative
Source Database / ID: 

pI: 7.0698 | Length (AA): 1112 | MW (Da): 127438 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF00169   PH domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005509   calcium ion binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
64 125 2m97 (A) 6 67 26.00 0 0.67 0.428655 -1.24
66 123 2ami (A) 15 72 24.00 0.0011 0.17 0.336658 -0.49
685 1084 4ejn (A) 6 438 29.00 0 1 0.604212 0.14
762 1105 1kob (A) 24 361 30.00 0 1 0.672853 -0.15
784 1107 3mwu (A) 0 369 40.00 0 1 0.639867 -0.26
787 1051 1phk (A) 15 291 42.00 0 1 0.742809 -0.66

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131887)

Species Accession Gene Product
Arabidopsis thaliana AT5G10930   CBL-interacting protein kinase 5
Arabidopsis thaliana AT5G07070   CBL-interacting protein kinase 2
Arabidopsis thaliana AT5G58380   CBL-interacting serine/threonine-protein kinase 10
Arabidopsis thaliana AT5G25110   CBL-interacting serine/threonine-protein kinase 25
Babesia bovis BBOV_II000610   asparagine rich protein, putative
Echinococcus granulosus EgrG_001009400   Kv channel interacting protein 4
Echinococcus multilocularis EmuJ_001009400   Kv channel interacting protein 4
Neospora caninum NCLIV_044860   hypothetical protein
Oryza sativa 4332786   Os03g0339900
Oryza sativa 4338445   Os05g0332300
Oryza sativa 4344287   Os07g0678600
Plasmodium berghei PBANKA_0925200   calcium-dependent protein kinase 7
Plasmodium falciparum PF3D7_1123100   calcium-dependent protein kinase 7
Plasmodium knowlesi PKNH_0920900   calcium-dependent protein kinase 7, putative
Plasmodium vivax PVX_091770   calcium-dependent protein kinase 7, putative
Plasmodium yoelii PY00029   myosin light chain kinase
Toxoplasma gondii TGME49_228750   calcium dependent protein kinase CDPK7
Theileria parva TP04_0518   protein kinase, putative

Essentiality

BBOV_II000610 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0925200 Plasmodium berghei Essential plasmo
TGME49_228750 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Patiria pectinifera Cdc2 300 aa 31.7% 300 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 27.9% 301 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 30.9% 301 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 28.9% 294 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 23.5% 293 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 25.9% 294 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 31.2% 285 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 29.5% 315 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier BBOV_II000610 (Babesia bovis), asparagine rich protein, putative
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