Detailed view for BBOV_III002900

Basic information

TDR Targets ID: 358682
Babesia bovis, casein kinase I, putative
Source Database / ID: 

pI: 9.5622 | Length (AA): 336 | MW (Da): 39225 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 331 5cyz (A) 0 348 49.00 0 1 1.46291 -0.1
7 299 4twc (A) 2 294 70.00 0 1 1.72772 -1.18
7 300 3sv0 (A) 2 295 70.00 0 1 1.7207 -1.08
10 298 1csn (A) 8 298 56.00 0 1 1.55792 -0.85

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126780)

Species Accession Gene Product
Arabidopsis thaliana AT1G03930   dual specificity kinase 1
Arabidopsis thaliana AT4G26100   casein kinase 1
Arabidopsis thaliana AT5G43320   casein kinase I-like 8
Arabidopsis thaliana AT4G14340   casein kinase I
Arabidopsis thaliana AT5G44100   casein kinase I-like 7
Arabidopsis thaliana AT2G19470   casein kinase I-like 5
Arabidopsis thaliana AT3G23340   casein kinase I-like 10
Arabidopsis thaliana AT1G72710   casein kinase 1-like protein 2
Arabidopsis thaliana AT5G57015   casein kinase I-like 12
Arabidopsis thaliana AT4G28540   casein kinase I-like 6
Arabidopsis thaliana AT1G04440   casein kinase like 13
Babesia bovis BBOV_III002900   casein kinase I, putative
Brugia malayi Bm1_37175   casein kinase 1, delta
Brugia malayi Bm1_45085   casein kinase I
Candida albicans CaO19.3476   Casein kinase I: DNA repair, meiosis
Candida albicans CaO19.10980   Casein kinase I: DNA repair, meiosis
Caenorhabditis elegans CELE_F46F2.2   Protein KIN-20, isoform F
Caenorhabditis elegans CELE_C03C10.1   Protein KIN-19
Cryptosporidium hominis Chro.30215   casein kinase i
Cryptosporidium parvum cgd3_1810   casein kinase I
Dictyostelium discoideum DDB_G0273737   casein kinase I
Dictyostelium discoideum DDB_G0273059   casein kinase I
Drosophila melanogaster Dmel_CG2028   Casein kinase Ialpha
Drosophila melanogaster Dmel_CG2048   discs overgrown
Echinococcus granulosus EgrG_000815700   casein kinase I alpha
Echinococcus granulosus EgrG_000689400   casein kinase i
Echinococcus granulosus EgrG_000089800   casein kinase I delta
Echinococcus granulosus EgrG_000686600   casein kinase I delta
Echinococcus granulosus EgrG_000637900   casein kinase I alpha
Echinococcus granulosus EgrG_000820700   casein kinase I alpha
Entamoeba histolytica EHI_151950   casein kinase, putative
Entamoeba histolytica EHI_156390   casein kinase 1, putative
Echinococcus multilocularis EmuJ_000820700   casein kinase I alpha
Echinococcus multilocularis EmuJ_000815700   casein kinase I alpha
Echinococcus multilocularis EmuJ_000637900   casein kinase I alpha
Echinococcus multilocularis EmuJ_000089800   casein kinase I delta
Echinococcus multilocularis EmuJ_000689400   casein kinase i
Echinococcus multilocularis EmuJ_000686600   casein kinase I delta
Giardia lamblia GL50803_7537   Kinase, CK1 Casein kinase
Homo sapiens 102800317   LOC400927-CSNK1E readthrough
Homo sapiens ENSG00000141551   casein kinase 1, delta
Homo sapiens ENSG00000213923   casein kinase 1, epsilon
Homo sapiens ENSG00000180138   casein kinase 1, alpha 1-like
Homo sapiens ENSG00000113712   casein kinase 1, alpha 1
Leishmania braziliensis LbrM.34.1000   casein kinase, putative
Leishmania donovani LdBPK_351030.1   casein kinase, putative
Leishmania infantum LinJ.35.1030   casein kinase, putative
Leishmania major LmjF.35.1010   casein kinase, putative
Leishmania mexicana LmxM.34.1010   casein kinase, putative
Loa Loa (eye worm) LOAG_01275   CK1/CK1/CK1-A protein kinase
Loa Loa (eye worm) LOAG_01274   CK1/CK1/CK1-A protein kinase
Loa Loa (eye worm) LOAG_05803   CK1/CK1/CK1-D protein kinase
Mus musculus ENSMUSG00000024576   casein kinase 1, alpha 1
Mus musculus ENSMUSG00000022433   casein kinase 1, epsilon
Mus musculus ENSMUSG00000025162   casein kinase 1, delta
Neospora caninum NCLIV_016840   AFL091Wp, related
Oryza sativa 4331096   Os02g0810400
Oryza sativa 4336396   Os04g0514800
Oryza sativa 4348890   Os10g0476300
Oryza sativa 4330018   Os02g0622100
Oryza sativa 4339803   Os05g0593800
Oryza sativa 4326345   Os01g0570500
Oryza sativa 9267711   Os01g0708400
Onchocerca volvulus OVOC6677  
Onchocerca volvulus OVOC8481  
Plasmodium berghei PBANKA_0912100   casein kinase 1, putative
Plasmodium falciparum PF3D7_1136500   casein kinase 1
Plasmodium knowlesi PKNH_0934700   casein kinase 1, putative
Plasmodium vivax PVX_092440   casein kinase 1, putative
Plasmodium yoelii PY06011   casein kinase i
Saccharomyces cerevisiae YPL204W   Hrr25p
Schistosoma japonicum Sjp_0055230   ko:K02218 casein kinase 1, putative
Schistosoma japonicum Sjp_0105060   Casein kinase I isoform delta, putative
Schistosoma japonicum Sjp_0304020   ko:K08959 casein kinase 1, delta, putative
Schistosoma mansoni Smp_169950   serine/threonine protein kinase
Schistosoma mansoni Smp_067810   protein kinase
Schmidtea mediterranea mk4.001951.08   Casein kinase I
Schmidtea mediterranea mk4.001458.07  
Schmidtea mediterranea mk4.019126.02   Casein kinase I
Schmidtea mediterranea mk4.002059.06  
Schmidtea mediterranea mk4.001279.00  
Schmidtea mediterranea mk4.004518.01   Casein kinase I
Schmidtea mediterranea mk4.000674.07   Casein kinase I
Schmidtea mediterranea mk4.027310.00   Casein kinase I
Schmidtea mediterranea mk4.000425.06  
Schmidtea mediterranea mk4.002059.07   Casein kinase I
Schmidtea mediterranea mk4.000988.05   Serine/threonine kinase
Schmidtea mediterranea mk4.000532.10  
Schmidtea mediterranea mk4.000988.06   Serine/threonine kinase
Trypanosoma brucei gambiense Tbg972.5.1140   casein kinase, putative
Trypanosoma brucei Tb927.5.800   casein kinase I, isoform 2
Trypanosoma congolense TcIL3000_0_32110   casein kinase I, isoform 2
Trypanosoma congolense TcIL3000_5_480   casein kinase, putative
Trypanosoma cruzi TcCLB.507305.20   casein kinase, putative
Trypanosoma cruzi TcCLB.508541.230   casein kinase, putative
Trypanosoma cruzi TcCLB.507305.30   casein kinase, putative
Trypanosoma cruzi TcCLB.504929.15   casein kinase, delta isoform, putative
Trypanosoma cruzi TcCLB.507541.40   casein kinase, putative
Trypanosoma cruzi TcCLB.508541.240   casein kinase, putative
Trypanosoma cruzi TcCLB.504929.10   casein kinase, delta isoform, putative
Toxoplasma gondii TGME49_240640   casein kinase I
Theileria parva TP03_0315   casein kinase I, putative
Trichomonas vaginalis TVAG_388850   CK1 family protein kinase
Trichomonas vaginalis TVAG_218210   CK1 family protein kinase
Trichomonas vaginalis TVAG_252620   CK1 family protein kinase

Essentiality

BBOV_III002900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C03C10.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_C03C10.1 Caenorhabditis elegans sterile wormbase
CELE_F46F2.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_F46F2.2 Caenorhabditis elegans larval lethal wormbase
CELE_F46F2.2 Caenorhabditis elegans slow growth wormbase
CELE_F46F2.2 Caenorhabditis elegans sterile wormbase
YPL204W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0912100 Plasmodium berghei Essential plasmo
TGME49_240640 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Sus scrofa Casein kinase I isoform alpha Compounds References
Homo sapiens casein kinase 1, epsilon Compounds References
Homo sapiens casein kinase 1, alpha 1-like Compounds References
Homo sapiens casein kinase 1, alpha 1 Compounds References
Homo sapiens casein kinase 1, delta Compounds References
Sus scrofa Casein kinase 1, delta tv1 Compounds References
Rattus norvegicus Casein kinase I delta Compounds References
Bos taurus Casein kinase I isoform alpha Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier BBOV_III002900 (Babesia bovis), casein kinase I, putative
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