Detailed view for Chro.40301

Basic information

TDR Targets ID: 362686
Cryptosporidium hominis, ataxia telangiectasia and Rad3-related protein
Source Database / ID: 

pI: 8.8663 | Length (AA): 1227 | MW (Da): 141566 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00454   Phosphatidylinositol 3- and 4-kinase
PF02260   FATC domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016301   kinase activity  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
28 1226 4jsn (B) 1393 2548 20.00 0 1 0.88138 1.3
31 853 3ibv (A) 39 883 11.00 0 0.35 0.536642 0.99
443 550 5fzs (A) 1 106 11.00 0.0045 0.05 0.21222 -0.55
1196 1225 2kio (A) 2 31 43.00 0 0.23 0.28435 1.02

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128386)

Species Accession Gene Product
Arabidopsis thaliana AT5G40820   serine/threonine-protein kinase ATR
Babesia bovis BBOV_III011480   phosphatidylinositol 3- and 4-kinase family protein
Brugia malayi Bm1_22870   Phosphatidylinositol 3- and 4-kinase family protein
Candida albicans CaO19.8870   potential phosphatidylinositol kinase similar to S. cerevisiae MEC1 (YBR136W) involved in DNA repair and recombination
Candida albicans CaO19.1283   potential phosphatidylinositol kinase similar to S. cerevisiae MEC1 (YBR136W) involved in DNA repair and recombination
Caenorhabditis elegans CELE_T06E4.3   Protein ATL-1, isoform C
Cryptosporidium hominis Chro.40300   hypothetical protein
Cryptosporidium hominis Chro.40299   hypothetical protein
Cryptosporidium hominis Chro.40301   ataxia telangiectasia and Rad3-related protein
Cryptosporidium parvum cgd4_2670   FRP1 like protein involved in DNA repair with a FAT domain and a phosphatidylinositol kinase domain at the C-terminus
Dictyostelium discoideum DDB_G0291380   ATR subfamily protein kinase
Drosophila melanogaster Dmel_CG4252   meiotic 41
Echinococcus granulosus EgrG_000457600   phosphatidylinositol 3 and 4 kinase
Entamoeba histolytica EHI_197310   Phosphatidylinositol 3- and 4-kinase family
Echinococcus multilocularis EmuJ_000457600   phosphatidylinositol 3 and 4 kinase
Homo sapiens ENSG00000175054   ATR serine/threonine kinase
Leishmania braziliensis LbrM.32.1620   phosphatidylinositol 3-related kinase, putative
Leishmania donovani LdBPK_321520.1   phosphatidylinositol 3-related kinase, putative
Leishmania infantum LinJ.32.1520   phosphatidylinositol 3-related kinase, putative
Leishmania major LmjF.32.1460   phosphatidylinositol 3-related kinase, putative
Leishmania mexicana LmxM.31.1460   phosphatidylinositol 3-related kinase, putative
Loa Loa (eye worm) LOAG_06382   hypothetical protein
Loa Loa (eye worm) LOAG_11558   hypothetical protein
Loa Loa (eye worm) LOAG_08139   phosphatidylinositol 3
Mus musculus ENSMUSG00000032409   ataxia telangiectasia and Rad3 related
Neospora caninum NCLIV_015320   phosphatidylinositol 3- and 4-kinase domain- containing protein, putative
Oryza sativa 4342103   Os06g0724700
Saccharomyces cerevisiae YBR136W   Mec1p
Schistosoma japonicum Sjp_0077490   ko:K06640 ataxia telangiectasia and Rad3 related, putative
Schistosoma japonicum Sjp_0075640   hypothetical protein
Schistosoma japonicum Sjp_0122790   Serine/threonine-protein kinase ATR, putative
Schistosoma japonicum Sjp_0112210   Serine/threonine-protein kinase atr, putative
Schistosoma mansoni Smp_162340   phosphatidylinositol 3-and 4-kinase
Schmidtea mediterranea mk4.015073.00  
Schmidtea mediterranea mk4.013442.01  
Schmidtea mediterranea mk4.024757.00  
Trypanosoma brucei gambiense Tbg972.11.16460   phosphatidylinositol 3-related kinase, putative
Trypanosoma brucei Tb927.11.14680   phosphatidylinositol 3-related kinase, putative
Trypanosoma cruzi TcCLB.506223.120   phosphatidylinositol 3-related kinase, putative
Trypanosoma cruzi TcCLB.511719.10   phosphatidylinositol 3-related kinase, putative
Trichomonas vaginalis TVAG_178360   PIKK family atypical protein kinase
Trichomonas vaginalis TVAG_493750   PIKK family atypical protein kinase

Essentiality

Chro.40301 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.6300 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.6300 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.6300 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.6300 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T06E4.3 Caenorhabditis elegans embryonic lethal wormbase
YBR136W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ATR serine/threonine kinase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Chro.40301 (Cryptosporidium hominis), ataxia telangiectasia and Rad3-related protein
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