pI: 6.9354 |
Length (AA): 655 |
MW (Da): 76032 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
263 | 424 | 1ygh (A) | 99 | 262 | 56.00 | 0 | 1 | 1.02813 | -1.47 |
312 | 410 | 2ae6 (A) | 53 | 157 | 18.00 | 0.028 | 0.2 | 0.230945 | 0.44 |
548 | 654 | 4ldf (A) | 8 | 114 | 99.99 | 0 | 1 | 1.49796 | -2.44 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127781)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G54610 | histone acetyltransferase GCN5 |
Babesia bovis | BBOV_I003750 | histone acetyltransferase |
Brugia malayi | Bm1_38035 | acetyltransferase, GNAT family protein |
Candida albicans | CaO19.8324 | bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase |
Candida albicans | CaO19.705 | bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase |
Caenorhabditis elegans | CELE_Y47G6A.6 | Protein PCAF-1 |
Cryptosporidium hominis | Chro.30361 | histone acetyltransferase |
Cryptosporidium parvum | cgd3_3190 | GCN5 like acetylase + bromodomain |
Dictyostelium discoideum | DDB_G0283459 | GCN5-related N-acetyltransferase |
Drosophila melanogaster | Dmel_CG4107 | Gcn5 ortholog |
Echinococcus granulosus | EgrG_000900000 | histone acetyltransferase KAT2B |
Echinococcus granulosus | EgrG_000899900 | histone acetyltransferase KAT2B |
Entamoeba histolytica | EHI_140660 | acetyltransferase, GNAT family |
Echinococcus multilocularis | EmuJ_000899900 | gcn5proteinral control of amino acid synthesis |
Giardia lamblia | GL50803_10666 | Histone acetyltransferase GCN5 |
Homo sapiens | ENSG00000108773 | K(lysine) acetyltransferase 2A |
Homo sapiens | ENSG00000114166 | K(lysine) acetyltransferase 2B |
Loa Loa (eye worm) | LOAG_03313 | acetyltransferase |
Mus musculus | ENSMUSG00000000708 | K(lysine) acetyltransferase 2B |
Mus musculus | ENSMUSG00000020918 | K(lysine) acetyltransferase 2A |
Neospora caninum | NCLIV_018170 | Bromodomain containing protein, related |
Neospora caninum | NCLIV_008840 | hypothetical protein |
Oryza sativa | 4348629 | Os10g0415900 |
Plasmodium berghei | PBANKA_0707300 | histone acetyltransferase GCN5, putative |
Plasmodium falciparum | PF3D7_0823300 | histone acetyltransferase GCN5 |
Plasmodium knowlesi | PKNH_1317300 | histone acetyltransferase GCN5, putative |
Plasmodium vivax | PVX_089200 | histone acetyltransferase GCN5, putative |
Plasmodium yoelii | PY02679 | histone acetyltransferase GCN5-related |
Saccharomyces cerevisiae | YGR252W | histone acetyltransferase GCN5 |
Schistosoma japonicum | Sjp_0076690 | ko:K06062 p300/CBP-associated factor, putative |
Schistosoma mansoni | Smp_070190 | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 |
Schmidtea mediterranea | mk4.001809.01 | Putative gcn5 |
Schmidtea mediterranea | mk4.001809.00 | |
Toxoplasma gondii | TGME49_254555 | histone lysine acetyltransferase GCN5-A |
Toxoplasma gondii | TGME49_243440 | histone lysine acetyltransferase GCN5-B |
Theileria parva | TP01_0465 | histone acetyltransferase Gcn5, putative |
Trichomonas vaginalis | TVAG_091650 | cat eye syndrome critical region protein 2, cscr2, putative |
Trichomonas vaginalis | TVAG_340910 | bromodomain-containing protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_0707300 | Plasmodium berghei | Essential | plasmo |
TGME49_243440 | Toxoplasma gondii | Probably essential | sidik |
TGME49_254555 | Toxoplasma gondii | Probably essential | sidik |
TGME49_243440 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_254555 | Toxoplasma gondii | Essentiality uncertain | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Saccharomyces cerevisiae | histone acetyltransferase GCN5 | Compounds | References |
Homo sapiens | K(lysine) acetyltransferase 2B | Compounds | References |
Homo sapiens | K(lysine) acetyltransferase 2A | Compounds | References |