Detailed view for TcCLB.481435.9

Basic information

TDR Targets ID: 36617
Trypanosoma cruzi, clathrin heavy chain, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.2206 | Length (AA): 516 | MW (Da): 59303 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00637   Region in Clathrin and VPS

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0005488   binding  
GO:0016192   vesicle-mediated transport  
GO:0006886   intracellular protein transport  

Metabolic Pathways

Endocytosis (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
14 129 2fo7 (A) 18 134 14.00 0.00000000038 0.13 0.33 -0.47
104 342 2ypf (A) 518 758 26.00 0.5 1 0.648178 -0.14
139 511 5h7c (A) 14 379 20.00 0.071 1 0.803868 0.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127480)

Species Accession Gene Product
Arabidopsis thaliana AT3G08530   Clathrin, heavy chain
Arabidopsis thaliana AT3G11130   Clathrin, heavy chain
Babesia bovis BBOV_IV001820   clathrin heavy chain
Brugia malayi Bm1_21545   Probable clathrin heavy chain
Candida albicans CaO19.3496   presumed vesical coat protein (clathrin heavy chain)
Candida albicans CaO19.10990   presumed vesical coat protein (clathrin heavy chain)
Caenorhabditis elegans CELE_T20G5.1   Protein CHC-1
Cryptosporidium hominis Chro.80150   clathrin, heavy polypeptide (Hc)
Cryptosporidium parvum cgd8_1270   clathrin heavy chain
Dictyostelium discoideum DDB_G0277221   clathrin heavy chain
Drosophila melanogaster Dmel_CG9012   Clathrin heavy chain
Echinococcus granulosus EgrG_000122200   clathrin heavy chain
Entamoeba histolytica EHI_201510   clathrin heavy chain, putative
Entamoeba histolytica EHI_201710   clathrin heavy chain, putative
Echinococcus multilocularis EmuJ_000122200   clathrin heavy chain
Giardia lamblia GL50803_102108   Clathrin heavy chain
Homo sapiens ENSG00000141367   clathrin, heavy chain (Hc)
Homo sapiens ENSG00000070371   clathrin, heavy chain-like 1
Leishmania braziliensis LbrM.35.1780   clathrin heavy chain, putative
Leishmania donovani LdBPK_361700.1   clathrin heavy chain, putative
Leishmania infantum LinJ.36.1700   clathrin heavy chain, putative
Leishmania major LmjF.36.1630   clathrin heavy chain, putative
Leishmania mexicana LmxM.36.1630   clathrin heavy chain, putative
Loa Loa (eye worm) LOAG_00018   clathrin
Mus musculus ENSMUSG00000047126   clathrin, heavy polypeptide (Hc)
Neospora caninum NCLIV_042820   cDNA FLJ58099, highly similar to Homo sapiens clathrin, heavy polypeptide-like 1 (CLTCL1), transcript variant 1, mRNA, related
Oryza sativa 4351255   Os12g0104800
Oryza sativa 4349546   Os11g0104900
Plasmodium berghei PBANKA_1434700   clathrin heavy chain, putative
Plasmodium falciparum PF3D7_1219100   clathrin heavy chain, putative
Plasmodium knowlesi PKNH_1438700   clathrin heavy chain, putative
Plasmodium vivax PVX_123620   clathrin heavy chain, putative
Plasmodium yoelii PY01854   putative clathrin heavy chain
Saccharomyces cerevisiae YGL206C   clathrin heavy chain
Schistosoma japonicum Sjp_0040780   Clathrin heavy chain 1, putative
Schistosoma japonicum Sjp_0217180   Clathrin heavy chain 1, putative
Schistosoma japonicum Sjp_0040760   ko:K04646 clathrin, heavy polypeptide, putative
Schistosoma mansoni Smp_154420.2   clathrin heavy chain
Schistosoma mansoni Smp_154420.1   clathrin heavy chain
Schmidtea mediterranea mk4.003441.00   Probable clathrin heavy chain 1
Trypanosoma brucei gambiense Tbg972.10.7400   clathrin heavy chain, putative
Trypanosoma brucei Tb927.10.6050   clathrin heavy chain
Trypanosoma brucei Tb11.v5.0198   clathrin heavy chain, putative
Trypanosoma brucei Tb11.v5.0197   clathrin heavy chain, putative
Trypanosoma congolense TcIL3000_10_5100   clathrin heavy chain, putative
Trypanosoma cruzi TcCLB.481435.9   clathrin heavy chain, putative
Trypanosoma cruzi TcCLB.506167.50   clathrin heavy chain, putative
Trypanosoma cruzi TcCLB.507785.10   clathrin heavy chain, putative
Toxoplasma gondii TGME49_290950   clathrin heavy chain, putative
Theileria parva TP03_0480   clathrin heavy chain, putative
Trichomonas vaginalis TVAG_516070   clathrin heavy chain, putative
Trichomonas vaginalis TVAG_558650   clathrin heavy chain, putative
Trichomonas vaginalis TVAG_502180   clathrin heavy chain, putative
Trichomonas vaginalis TVAG_532880   clathrin heavy chain, putative
Trichomonas vaginalis TVAG_369020   clathrin heavy chain, putative

Essentiality

TcCLB.481435.9 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.6050 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.6050 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.6050 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.6050 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T20G5.1 Caenorhabditis elegans adult lethal wormbase
CELE_T20G5.1 Caenorhabditis elegans embryonic arrest wormbase
CELE_T20G5.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_T20G5.1 Caenorhabditis elegans larval lethal wormbase
CELE_T20G5.1 Caenorhabditis elegans sterile wormbase
YGL206C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1434700 Plasmodium berghei Essential plasmo
TGME49_290950 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens clathrin, heavy chain (Hc) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.481435.9 (Trypanosoma cruzi), clathrin heavy chain, putative
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