Detailed view for TcCLB.510187.150

Basic information

TDR Targets ID: 36926
Trypanosoma cruzi, guanylate kinase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.3901 | Length (AA): 240 | MW (Da): 26930 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00625   Guanylate kinase

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Purine metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 239 1s96 (A) 3 193 36.00 0 1 1.19 -0.08
6 233 1ex7 (A) 2 186 39.00 0 1 1.21 -0.44
1 238 3lnc (A) 2 194 29.00 0 1 0.897967 0.58
4 236 1s96 (A) 3 190 38.00 0 1 1.20363 -0.09
6 237 1lvg (A) 5 193 37.00 0 1 1.22127 -0.18
7 229 4f4j (B) 4 183 41.00 0 1 1.05847 0.05
8 236 1z6g (A) 7 193 32.00 0 1 1.14347 -0.25

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_153789)

Species Accession Gene Product
Leishmania braziliensis LbrM.35.2500   guanylate kinase-like protein
Leishmania donovani LdBPK_362390.1   guanylate kinase-like protein
Leishmania infantum LinJ.36.2390   guanylate kinase-like protein
Leishmania major LmjF.36.2260   guanylate kinase-like protein
Leishmania mexicana LmxM.36.2260   guanylate kinase-like protein
Trypanosoma brucei gambiense Tbg972.10.8310   guanylate kinase, putative
Trypanosoma brucei Tb927.10.6810   guanylate kinase, putative
Trypanosoma congolense TcIL3000_0_06640   guanylate kinase, putative
Trypanosoma cruzi TcCLB.510187.150   guanylate kinase, putative

Essentiality

TcCLB.510187.150 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.6810 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.6810 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.6810 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.6810 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.510187.150 (Trypanosoma cruzi), guanylate kinase, putative
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