pI: 7.7594 |
Length (AA): 295 |
MW (Da): 33845 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 293 | 3niz (A) | 19 | 311 | 99.99 | 0 | 1 | 2.20522 | -1.58 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Ortholog group members (OG5_126712)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G48750 | cyclin-dependent kinase A-1 |
Babesia bovis | BBOV_IV010650 | cell division control protein 2, putative |
Brugia malayi | Bm1_01435 | cell division control protein 2 homolog |
Brugia malayi | Bm1_18520 | Protein kinase domain containing protein |
Candida albicans | CaO19.11337 | Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase |
Candida albicans | CaO19.3856 | Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase |
Caenorhabditis elegans | CELE_T05G5.3 | Protein CDK-1 |
Caenorhabditis elegans | CELE_T27E9.3 | Protein CDK-5 |
Cryptosporidium hominis | Chro.50127 | cdc2-like protein kinase |
Cryptosporidium parvum | cgd5_2510 | Cdc2-like CDK2/CDC28 like protein kinase |
Dictyostelium discoideum | DDB_G0272813 | CDC2 subfamily protein kinase |
Dictyostelium discoideum | DDB_G0288677 | CDK family protein kinase |
Drosophila melanogaster | Dmel_CG5363 | CG5363 gene product from transcript CG5363-RA |
Drosophila melanogaster | Dmel_CG8203 | Cyclin-dependent kinase 5 |
Drosophila melanogaster | Dmel_CG10498 | CG10498 gene product from transcript CG10498-RC |
Echinococcus granulosus | EgrG_001201200 | cyclin dependent kinase 1 |
Echinococcus granulosus | EgrG_002003450 | 5'partial|cyclin dependent kinase 1 |
Echinococcus granulosus | EgrG_000258800 | cyclin dependent kinase 5 |
Echinococcus granulosus | EgrG_000659500 | cyclin dependent kinase |
Entamoeba histolytica | EHI_152430 | cell division protein kinase 2, putative |
Entamoeba histolytica | EHI_065280 | cell division protein kinase 2, putative |
Echinococcus multilocularis | EmuJ_000258800 | cyclin dependent kinase 5 |
Echinococcus multilocularis | EmuJ_001201200 | cyclin dependent kinase 1 |
Echinococcus multilocularis | EmuJ_000046100 | cyclin dependent kinase 1 |
Echinococcus multilocularis | EmuJ_000659500 | cyclin dependent kinase |
Giardia lamblia | GL50803_8037 | Kinase, CMGC CDK |
Giardia lamblia | GL50803_16802 | Kinase, CMGC CDK |
Homo sapiens | ENSG00000164885 | cyclin-dependent kinase 5 |
Homo sapiens | ENSG00000170312 | cyclin-dependent kinase 1 |
Homo sapiens | ENSG00000261408 | cyclin-dependent kinase 3 |
Leishmania braziliensis | LbrM.35.0660 | cell division related protein kinase 2,cdc2-related kinase |
Leishmania braziliensis | LbrM.21.1310 | cell division protein kinase 2,cdc2-related kinase |
Leishmania donovani | LdBPK_211320.1 | cell division protein kinase 2 |
Leishmania donovani | LdBPK_360600.1 | cdc2-related kinase 3, putative |
Leishmania infantum | LinJ.36.0600 | cell division related protein kinase 2,cdc2-related kinase |
Leishmania infantum | LinJ.21.1320 | cell division protein kinase 2,cdc2-related kinase |
Leishmania major | LmjF.36.0550 | cell division related protein kinase 2,cdc2-related kinase |
Leishmania major | LmjF.21.1080 | cell division protein kinase 2,cdc2-related kinase |
Leishmania mexicana | LmxM.21.1080 | cell division protein kinase 2,cdc2-related kinase |
Leishmania mexicana | LmxM.36.0550 | cell division related protein kinase 2,cdc2-related kinase |
Loa Loa (eye worm) | LOAG_07241 | hypothetical protein |
Loa Loa (eye worm) | LOAG_07240 | CMGC/CDK/CDK5 protein kinase |
Loa Loa (eye worm) | LOAG_04543 | CMGC/CDK/CDC2 protein kinase |
Loa Loa (eye worm) | LOAG_00683 | CMGC/CDK/CDC2 protein kinase |
Mus musculus | ENSMUSG00000019942 | cyclin-dependent kinase 1 |
Mus musculus | ENSMUSG00000025358 | cyclin-dependent kinase 2 |
Mus musculus | ENSMUSG00000028969 | cyclin-dependent kinase 5 |
Neospora caninum | NCLIV_062010 | CMGC kinase, CDK family TgPK2, putative |
Oryza sativa | 4331415 | Os03g0118400 |
Oryza sativa | 4331341 | Os03g0108800 |
Oryza sativa | 9269568 | Os01g0897000 |
Oryza sativa | 4328135 | Os02g0123100 |
Plasmodium berghei | PBANKA_1133200 | cdc2-related kinase 2 |
Plasmodium falciparum | PF3D7_1356900 | protein kinase 5 |
Plasmodium knowlesi | PKNH_1114600 | Cell division control protein 2 homolog |
Plasmodium vivax | PVX_114825 | protein kinase Crk2 |
Plasmodium yoelii | PY02339 | cdc2-related kinase 2 |
Saccharomyces cerevisiae | YBR160W | cyclin-dependent serine/threonine-protein kinase CDC28 |
Saccharomyces cerevisiae | YPL031C | cyclin-dependent serine/threonine-protein kinase PHO85 |
Schistosoma japonicum | Sjp_0069610 | ko:K02090 cyclin-dependent kinase 5, putative |
Schistosoma japonicum | Sjp_0031130 | ko:K02087 cyclin-dependent kinase 1, putative |
Schistosoma mansoni | Smp_073340 | serine/threonine protein kinase |
Schistosoma mansoni | Smp_080730 | serine/threonine protein kinase |
Schmidtea mediterranea | mk4.004426.03 | |
Schmidtea mediterranea | mk4.004810.01 | |
Schmidtea mediterranea | mk4.003639.00 | |
Schmidtea mediterranea | mk4.016510.00 | Cyclin-dependent kinase 5 |
Schmidtea mediterranea | mk4.004403.00 | Cell division control protein 2 cognate |
Schmidtea mediterranea | mk4.001381.05 | Cyclin-dependent kinase 1 |
Schmidtea mediterranea | mk4.001869.00 | |
Schmidtea mediterranea | mk4.008987.01 | Cyclin-dependent kinase 1 |
Schmidtea mediterranea | mk4.008987.00 | Cyclin-dependent kinase 1 |
Schmidtea mediterranea | mk4.005251.00 | |
Schmidtea mediterranea | mk4.003110.00 | Cell division control protein 2 cognate |
Schmidtea mediterranea | mk4.008040.02 | Cyclin-dependent kinase 1 |
Schmidtea mediterranea | mk4.016640.01 | |
Schmidtea mediterranea | mk4.002949.00 | Cyclin-dependent kinase 1 |
Schmidtea mediterranea | mk4.003414.10 | Cyclin-dependent kinase 1 |
Trypanosoma brucei gambiense | Tbg972.10.1330 | cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative |
Trypanosoma brucei gambiense | Tbg972.10.6040 | cell division related protein kinase 2, putative,CDC2-related protein kinase |
Trypanosoma brucei | Tb927.10.4990 | cdc2-related kinase 3 |
Trypanosoma brucei | Tb927.10.1070 | cdc2-related kinase 1 |
Trypanosoma congolense | TcIL3000_10_4170 | cdc2-related kinase 3, putative |
Trypanosoma congolense | TcIL3000_10_880 | cdc2-related kinase 1, putative |
Trypanosoma cruzi | TcCLB.509695.190 | cdc2-related kinase 1 |
Trypanosoma cruzi | TcCLB.506677.20 | cdc2-related kinase 3 |
Trypanosoma cruzi | TcCLB.506583.40 | cdc2-related kinase 3 |
Trypanosoma cruzi | TcCLB.504181.40 | cdc2-related kinase 1 |
Toxoplasma gondii | TGME49_218220 | cell-cycle-associated protein kinase CDK, putative |
Theileria parva | TP01_0728 | cell division control protein 2 related kinase |
Trichomonas vaginalis | TVAG_453900 | CMGC family protein kinase |
Trichomonas vaginalis | TVAG_076000 | CMGC family protein kinase |
Trichomonas vaginalis | TVAG_225330 | CMGC family protein kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.4990 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.4990 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.4990 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.4990 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.10.1070 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.1070 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.1070 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.1070 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T05G5.3 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_T05G5.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T05G5.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T05G5.3 | Caenorhabditis elegans | sterile | wormbase |
CELE_T27E9.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
YBR160W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_218220 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | Compounds | References |
Plasmodium falciparum | protein kinase 5 | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | Compounds | References |
Homo sapiens | cyclin-dependent kinase 3 | Compounds | References |
Homo sapiens | cyclin-dependent kinase 5 | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | Compounds | References |
Saccharomyces cerevisiae | cyclin-dependent serine/threonine-protein kinase CDC28 | Compounds | References |
Patiria pectinifera | Cdc2 | Compounds | References |
Mus musculus | cyclin-dependent kinase 1 | Compounds | References |
Saccharomyces cerevisiae | cyclin-dependent serine/threonine-protein kinase PHO85 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 47.6% | 187 aa | Compounds | References |